Blockade of renin–angiotensin system prevents micturition dysfunction in renovascular hypertensive rats

Ramos-Filho, Antonio Celso Saragossa; Moscoso, Julio; Calmasini, Fabiano Beraldi; Faria, Juliana de Almeida; Anhê, Gabriel Forato; Mónica, Fabíola Z.; Antunes, Edson

doi:10.1016/j.ejphar.2014.05.038

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…Celso et al . also showed that RAS blockade with losartan or captopril prevented neurogenic contraction and voiding frequency in renovascular hypertensive rats . Olmesartan was observed to ameliorate bladder dysfunction by recovering bladder blood flow and decreasing oxidative stress in spontaneous hypertension rats …”

Section: Ras In Urological Diseases (Table )mentioning

confidence: 84%

“…89 Celso et al also showed that RAS blockade with losartan or captopril prevented neurogenic contraction and voiding frequency in renovascular hypertensive rats. 90 Olmesartan was observed to ameliorate bladder dysfunction by recovering bladder blood flow and decreasing oxidative stress in spontaneous hypertension rats. 91 A large clinical study including 3790 men showed that IPSS was lower in patients with hypertension receiving RAS inhibitors than in hypertensive patients who were not receiving any medication.…”

Section: Lutsmentioning

confidence: 99%

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Renin–angiotensin system blockade: Its contribution and controversy

et al. 2015

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Angiotensin II is a key biological peptide in the renin-angiotensin system that regulates blood pressure and renal hemodynamics, and extensive experimental studies have shown that angiotensin II promotes diverse fibrotic changes and induces neovascularization in several inflammatory diseases. It is known that angiotensin II can be controlled using renin-angiotensin system blockade when angiotensin II is the main factor inducing a particular disease, and renin-angiotensin system blockade has assumed a central role in the treatment of inflammatory nephritis, cardiovascular disorders and retinopathy. In contrast, renin-angiotensin system blockade was found to have not only these effects but also other functions, such as inhibition of cancer growth, angiogenesis and metastasis. Numerous studies have sought to elucidate the mechanisms and support these antitumor effects. However, a recent meta-analysis showed that renin-angiotensin system blockade use might in fact increase the incidence of cancer, so renin-angiotensin system blockade use has become somewhat controversial. Although the renin-angiotensin system has most certainly made great contributions to experimental models and clinical practice, some issues still need to be resolved. The present review discusses the contribution and controversy surrounding the renin-angiotensin system up to the present time.

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Section: Ras In Urological Diseases (Table )mentioning

confidence: 84%

Section: Lutsmentioning

confidence: 99%

Renin–angiotensin system blockade: Its contribution and controversy

et al. 2015

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“…Conversely, bladder dysfunction was revealed in an experimental model of renovascular hypertension with tissue remodeling and enhanced muscarinic M(3)-mediated contractions associated with reduced beta-adrenoceptor-mediated signal transduction [27]. The same authors showed bladder function improvement with losartan and captopril [28]. Jeronimo et al reported a case of a 13-month-old baby with severe RVH (bilateral renal artery stenosis) that manifested with failure to thrive, recent muscular weakness of the lower extremities, and irritability.…”

Section: Discussionmentioning

confidence: 98%

An unusual cause of renovascular hypertension in a pediatric patient with chronic kidney disease

Skrzypczyk

Kanclerz

Ostrowska

et al. 2022

Arterial Hypertension

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Background: Renovascular hypertension (RVH) accounts for 5-10% of arterial hypertension in children and is most commonly caused by fibromuscular dysplasia. Sporadically, renal artery stenosis in pediatric patients is caused by extrinsic compressive masses. Case report: A 12-year-old patient with complex urinary tract defect (dysplastic left kidney -nephrectomy at 11 months, right ectopic kidney in the midline, behind the urinary bladder), chronic kidney disease (CKD) stage 2, and arterial hypertension was admitted to the hospital due to worsening of kidney function during angiotensin-converting enzyme inhibitor (ACE-I) therapy. CT angiography revealed a right ectopic kidney located above the bladder, supplied by a single renal artery originating from the right common iliac artery. The renal artery had a tortuous shape with width in the ostium approx. 4.5 mm; then, the artery was bent and ran between the common iliac artery and the kidney. Ultrasound performed with a filled bladder showed bending and stenosis of the renal artery at the origin from the right common iliac -peak systolic velocity (PSV) 4.5-5.5 m/s and renal-aortic ratio (RAR) 3.1. With an empty bladder, no bending or stenosis was visible (PSV 1.7-1.9 m/s and RAR 1.0). Uroflowmetry revealed a dysfunctional micturition curve, large bladder capacity, and post-void urine retention. ACE-I was changed to beta-blocker and doxazosin, which led to blood pressure and kidney function normalization. Conclusions: Renal ectopia associated with bladder dysfunction may result in renal artery stenosis causing renovascular hypertension.

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“…The establishment and maintenance of hypertension principally depend on renin-angiotensin system (RAS) activity. 32 Angiotensin II (Ang II), a key element of this system, plays a pivotal role in the pathogenesis of clinical and experimental hypertension, 33 and also modulates fluid balance and the cardiovascular 34 and urinary systems. As a vascular risk factor, hypertension has been reported to play a role in the development of urinary tract symptoms.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

Janiuk¹,

Kasacka

2015

Eur J Histochem

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Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells.As this study provides novel findings, the question appears about the type of connection between hypertension and the functioning and activity of CART in the urinary tract (UT). The study gives rise to the assumption that high blood pressure can be a factor that intensifies CART secretion. In conclusion, the endocrine system of the urinary tract is modified by renovascular hypertension. This may affect the production of hormones and biologically active substances and contribute to the development of possible hypertension complications. In order to fully comprehend the role of the CART peptide in blood pressure regulation, further analyses are necessary.

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Blockade of renin–angiotensin system prevents micturition dysfunction in renovascular hypertensive rats

Cited by 8 publications

References 33 publications

Renin–angiotensin system blockade: Its contribution and controversy

Renin–angiotensin system blockade: Its contribution and controversy

An unusual cause of renovascular hypertension in a pediatric patient with chronic kidney disease

Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

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