1998
DOI: 10.1159/000054311
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Blockade of the Oestrogen-Induced Luteinizing Hormone Surge in Ovariectomized Ewes by a Highly Selective Opioid µ-Receptor Agonist: Evidence for Site of Action

Abstract: Endogenous opioid systems in the hypothalamus inhibit gonadotropin-releasing hormone (GnRH) secretion, and a reduction in this inhibitory input (disinhibition) is thought to be part of the neural mechanism of the preovulatory GnRH/luteinizing hormone (LH) surge. We showed previously that intracerebroventricular infusion of the highly specific opioid µ-receptor agonist DAMGO delayed the oestrogen-induced LH surge in ovariectomized (OVX) ewes, whereas both δ- and ĸ-agonists were ineffective. The aim of the prese… Show more

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Cited by 13 publications
(8 citation statements)
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“…Concentrations of ␤-endorphin in the median eminence have been measured to be higher during the late follicular compared with early luteal phase (306) and correspondingly to show a progressive increase from the luteal to follicular phase (344). Moreover, infusion of ␤-endorphin into the posterior-lateral median eminence decreases both GnRH and LH release (344), and infusion of an opioid -receptor agonist into either the preoptic area or mediobasal hypothalamus delays LH surge onset (345). Measurements of POMC mRNA levels in the arcuate nucleus, however, either show no difference during the GnRH/LH surge compared with either the luteal phase or the portion of the follicular phase preceding the surge (346,347) or are increased at the peak of the LH surge in OVXϩE ewes compared with OVX controls (346).…”
Section: H Endogenous Opioid Peptidesmentioning
confidence: 99%
“…Concentrations of ␤-endorphin in the median eminence have been measured to be higher during the late follicular compared with early luteal phase (306) and correspondingly to show a progressive increase from the luteal to follicular phase (344). Moreover, infusion of ␤-endorphin into the posterior-lateral median eminence decreases both GnRH and LH release (344), and infusion of an opioid -receptor agonist into either the preoptic area or mediobasal hypothalamus delays LH surge onset (345). Measurements of POMC mRNA levels in the arcuate nucleus, however, either show no difference during the GnRH/LH surge compared with either the luteal phase or the portion of the follicular phase preceding the surge (346,347) or are increased at the peak of the LH surge in OVXϩE ewes compared with OVX controls (346).…”
Section: H Endogenous Opioid Peptidesmentioning
confidence: 99%
“…Opioids affect this system mainly through the modulation of GnRH and LH secretion [1][2][3][4][5][6][7]. In addition, the β-endorphin participates to the control of reproductive function through a direct local action within reproductive tissues.…”
Section: Introductionmentioning
confidence: 99%
“…The reduction of this inhibition is necessary for the preovulatory surge of LH (Spijkstra et al, 1988;Walsh and Clarke, 1998). Gonadal steroids also exert an inhibitory effect on gonadotropin secretion (negative feedback action) and this effect is mediated (at least in part) by an increase in the opioidergic tone of the hypothalamus which is the cause of decreased GnRH secretion and a subsequent reduction of LH release (Ferin et al, 1984;Melis et al, 1984).…”
mentioning
confidence: 99%