Blockage of amyloid β peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells

Huang, Hsueh‐Meei; Ou, Hsio-Chung; Hsieh, Shon-Jean; Chiang, Li-Chi

doi:10.1016/s0024-3205(00)00470-7

Cited by 57 publications

(34 citation statements)

References 25 publications

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“…19) Furthermore, fullerenol-1, a watersoluble carboxylfullerene derivative, lowered the calcium increase by modifying membrane properties. 19) In addition, phloretin (a plant-derived substance) and estradiol attenuated the increase in intracellular calcium by modifying membrane fluidity and membrane potential. 20) In our system, neither channel blockers nor NMDA receptor inhibitors altered the intracellular calcium levels (unpublished data) induced by A.…”

mentioning

confidence: 99%

Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation

Kim

Sul

Lim

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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mentioning

confidence: 99%

Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation

Kim

Sul

Lim

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…Presumably, the neuroprotective effect of fullerenols is due to, both, anti-oxidant reactions and inhibition of Aβ 42 -induced Ca 2+ neurotoxicity. Huang et al validated the latter finding in their investigation into the effect of fullerenol-1 upon Aβ-induced Ca ++ influx in the cultured neurons [45]. Altogether, promising applications of functionalized fullerene derivatives including carboxyfullerene, hydroxyfullerene (fullerenols) and C 60 HyFn are in discovery of new drugs for AD.…”

Section: Fullerenementioning

confidence: 86%

Nanotechnology for Alzheimer’s disease detection and treatment

Nazem¹,

Mansoori²

2011

Insciences J.

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Abstract:In this paper, we present the role of nanotechnology in the development and improvement of techniques for early diagnosis and effective treatment of Alzheimer's disease (AD). Since AD pathology is almost irreversible and present-day medications for AD only lower its associated symptoms, application of disease-modifying treatments could be successful only if AD early diagnosis is possible. The nanodiagnostic methods reported and compared in this paper include both of in vitro and in vivo nature. Of the in vitro approaches, the DNA-nanoparticle conjugates (bio-barcode assay), nanoparticle surface plasmon resonance, scanning tunneling microscopy, and two-photon Rayleigh spectroscopy are presented here. Of the in vivo methods, µMRI and optical imaging techniques are discussed here. The nanotreatment methods for AD are numerous. They are categorized in this report under neuroprotective methods from toxicity of amyloid-β peptide (Aβ) oligomers, oxidative stress of free radicals and nanocarriers for targeted drug delivery. The important agents for neuroprotection include nanogels, fullerene, nano-ceria, dendrimers, gold nanoparticles, and diamondoid derivatives. The major nanocarriers presented here include cholinesterase inhibitors nanocarriers, acetylcholine nanocarrier, metal chelator nanocarriers, (Iron chelators and copper chelators), curcuminoids nanocarrier, anti-oxidant nanocarriers, and gene nanocarriers. Considering that the AD is a multi-factorial disease with several pathogenetic mechanisms and pathways, a multifunctional nanotechnology approach will be needed to target its main molecular culprits. These molecular targets must include, but not limited to, Aβ oligomers, reactive oxygen species (ROS), excessive metal ions, tau phosphorylating kinases and cell cycle proteins.

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“…As a result, cell-to-cell communications in the CNS and, in general, the neuronal activity can be disrupted, and the processes of adaptation of the nerve tissue under conditions of metabolic insult are significantly worsened. It was shown that one of the pathways providing the neuroprotective action of fullerenes is the involvement of these agents in the control of the level of free Са 2+ ions in the cytosol [32]. It seems probable that just the recovery of the intracellular Са 2+ pool under the action of fullerenes prevents calpain-induced proteolysis of GFAP and maintains the stability of organization of the cytoskeletal intermediate filaments in astrocytes.…”

Section: Discussionmentioning

confidence: 99%

Chronic alcoholization-induced damage to astroglia and intensification of lipid peroxidation in the rat brain: Protector effect of hydrated form of fullerene C60

et al. 2007

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We studied the intensity of lipid peroxidation (LP) and the amount of a marker of astrocytes (glial fibrillary acidic protein, GFAP) in tissues of the rat brain under conditions of long-lasting consumption (12 weeks) of ethyl alcohol, as well as the protective effects of peroral administration of hydrated forms of fullerene С 60 (С 60 HyFn, FWS, fullerene water solutions). Consumption of ethanol resulted in a rise in the amount of molecular markers of oxidative stress (thiobarbiturate-active compounds) in the cerebral tissues. The level of the filamentous GFAP form in the hippocampus and cerebral cortex of alcoholized animals decreased significantly, which can be a result of death of the population of GFAP-imunnoreactive astrocytes in the brain. In the brain of rats after systematic consumption of both ethanol and an aqueous solution of hydrated fullerenes С 60 , the amounts of products of lipid peroxidation and of the astroglial marker did not differ significantly from the respective indices in the control animals. Our data demonstrate the efficiency of hydrated fullerenes as pathogenetic therapeutic remedies for elimination of the negative effects of ethyl alcohol on the CNS.

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Blockage of amyloid β peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in PC12 cells

Cited by 57 publications

References 25 publications

Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation

Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation

Nanotechnology for Alzheimer’s disease detection and treatment

Chronic alcoholization-induced damage to astroglia and intensification of lipid peroxidation in the rat brain: Protector effect of hydrated form of fullerene C60

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