Blocking circ_0014130 suppressed drug resistance and malignant behaviors of docetaxel resistance-acquired NSCLC cells via regulating miR-545-3p-YAP1 axis

Du, Dongjie; Cao, Xiaoci; Duan, Xinbo; Zhang, Xianbo

doi:10.1007/s10616-021-00478-z

Cited by 18 publications

(16 citation statements)

References 39 publications

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“…Chen et al found that circ_0006404 and circ_0000735 could co-regulate the response of ovarian cancer to DTX treatment [ 51 ]. Another study revealed that blocking circ_0014130 could weaken the drug resistance of DTX-resistant non-small cell lung cancer via regulating miR-545-3p-YAP1 axis [ 52 ]. CircRNA CRIM1 was reported to promote nasopharyngeal carcinoma DTX chemoresistance through upregulating FOXQ1 [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Chen

Song

Hou

et al. 2022

J Exp Clin Cancer Res

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Background Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC). Recently, strategies targeting the mitosis error correction mechanism including chromosomal passenger complex (CPC) were reported to reverse the resistance to microtubule-targeting anticancer agents. Meanwhile, accumulating evidence indicated the important roles of circRNAs in DTX resistance of prostate cancer (PCa). However, whether circRNAs could regulate DTX chemosensitivity by affecting the mitosis error correction mechanism remains unclear. Methods Expression patterns of circ_0004087 and BUB1 were determined through mining the public circRNA datasets and performing western blot and qRT-PCR assays. Agarose gel electrophoresis, Sanger sequencing, and RNase R treatment were conducted to examine the circular characteristics of circ_0004087. CircRNA pull-down, mass spectrometry analysis, Co-IP, and dual-luciferase reporter assays were performed to uncover the interaction among circ_0004087, SND1, and MYB. The effects of circ_0004087 and BUB1 on docetaxel-based chemotherapy were explored by flow cytometry and in vivo drug studies upon xenografted tumor model. Results In the present study, we revealed the profound interaction between a novel circRNA, circ_0004087, and the mitosis error correction mechanism. Mechanistically, circ_0004087 binding with transcriptional coactivator SND1 could stimulate the transactivation of MYB and enhance the expression of downstream target BUB1. In turn, elevated BUB1 expression further recruited CPC to centromeres and guaranteed the error-free mitosis of PCa cells. Biologically, the overexpression of circ_0004087 conferred while the knockdown impaired DTX resistance in PCa cells. Conclusions Our study uncovered the crucial role of circ_0004087/SND1/MYB/BUB1 axis in modulating the error mitosis correction mechanism and DTX chemoresistance, suggesting that circ_0004087 may serve as a valuable prognostic biomarker and a potential therapeutic target in DTX-resistant PCa patients.

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Section: Discussionmentioning

confidence: 99%

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Chen

Song

Hou

et al. 2022

J Exp Clin Cancer Res

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“…Circ_0001361 has been found to be dependent on the miR‐525‐5p/VMA21 axis to promote tumorigenesis and progression of lung adenocarcinoma 26 . Interfering circ_00014130 reduced chemoresistance and malignance in docetaxel‐resistant NSCLC cells through interacting with the miR‐545‐3p/YAP1 network 27 . Additionally, circRNA_103809/miR‐377‐3p/GOT1 axis affected chemosensitivity of DDP in lung cancer cells 10 .…”

Section: Discussionmentioning

confidence: 99%

“… 26 Interfering circ_00014130 reduced chemoresistance and malignance in docetaxel‐resistant NSCLC cells through interacting with the miR‐545‐3p/YAP1 network. 27 Additionally, circRNA_103809/miR‐377‐3p/GOT1 axis affected chemosensitivity of DDP in lung cancer cells. 10 This study identified miR‐6751‐3p as a possible miRNA between circ_0002360 and ZNF300.…”

Section: Discussionmentioning

confidence: 99%

Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR‐6751‐3p to regulate the expression of ZNF300

Ding¹,

Liu²,

Tang³

2022

Thoracic Cancer

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Background: Circular RNAs (circRNAs) are key regulators in oncogenesis and chemoresistance of human cancers. Herein, we focused on the roles of circ_0002360 in regulating lung cancer progression and cisplatin (DDP) resistance. Methods: The detection of circ_0002360, microRNA-6751-3p (miR-6751-3p) and zinc finger protein 300 (ZNF300) was conducted via reverse transcription-quantitative polymerase chain reaction assay. Cell sensitivity was determined using cell counting kit-8 assay. Proliferation detection was performed by colony formation assay and EdU assay. The migrated cells were examined via transwell assay. Cell apoptosis analysis was carried out through flow cytometry and caspase 3 activity assay. Western blot was used to examine the protein levels. Target interaction was confirmed through dualluciferase reporter assay and RNA immunoprecipitation assay. Circ_0002360 function in vivo was performed via xenograft tumor assay. Results: Circ_0002360 was overexpressed in DDP-resistant lung cancer tissues and cells. Silencing circ_0002360 inhibited DDP resistance, proliferation and migration but enhanced apoptosis of DDP-resistant cells. Circ_0002360 could elevate ZNF300 expression. DDP resistance and lung cancer progression were also impeded by ZNF300 downregulation. ZNF300 overexpression reversed the function of circ_ 0002360 knockdown in DDP-resistant lung cancer cells. The regulation of circ_0002360 for ZNF300 was achieved by sponging miR-6751-3p. Circ_0002360 promoted DDP resistance in xenograft mice through mediating the miR-6751-3p/ZNF300 axis. Conclusion: Circ_0002360 targeted miR-6751-3p to regulate ZNF300 level, thus elevating DDP resistance and promoting the malignant progression of lung cancer cells.

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“…Du et al. explored a special circ_0014130-miR-545-3p-YAP1 pathway in the modulation of drug resistance and malignant behaviors of docetaxel (DTX)-resistant NSCLC cells ( 78 ). circ_0003998 knockdown suppresses colony formation and facilitates apoptosis and DTX sensitivity by sponging miR-136-5p to control CORO1C expression in DTX-resistant NSCLC cells ( 79 ).…”

Section: Circrnas and Drug Resistancementioning

confidence: 99%

The Role of Circular RNAs in the Drug Resistance of Cancers

et al. 2022

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Cancer is a major threat to human health and longevity. Chemotherapy is an effective approach to inhibit cancer cell proliferation, but a growing number of cancer patients are prone to develop resistance to various chemotherapeutics, including platinum, paclitaxel, adriamycin, and 5-fluorouracil, among others. Significant progress has been made in the research and development of chemotherapeutic drugs over the last few decades, including targeted therapy drugs and immune checkpoint inhibitors; however, drug resistance still severely limits the application and efficacy of these drugs in cancer treatment. Recently, emerging studies have emphasized the role of circular RNAs (circRNAs) in the proliferation, migration, invasion, and especially chemoresistance of cancer cells by regulating the expression of related miRNAs and targeted genes. In this review, we comprehensively summarized the potential roles and mechanisms of circRNAs in cancer drug resistance including the efflux of drugs, apoptosis, intervention with the TME (tumor microenvironment), autophagy, and dysfunction of DNA damage repair, among others. Furthermore, we highlighted the potential value of circRNAs as new therapeutic targets and prognostic biomarkers for cancer.

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Blocking circ_0014130 suppressed drug resistance and malignant behaviors of docetaxel resistance-acquired NSCLC cells via regulating miR-545-3p-YAP1 axis

Cited by 18 publications

References 39 publications

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR‐6751‐3p to regulate the expression of ZNF300

The Role of Circular RNAs in the Drug Resistance of Cancers

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