Blood- and Milk-Levels Produced by Sulphone and Various Sulphonamides in Domestic Animals

Francis, John

doi:10.1016/s0368-1742(49)80023-3

Cited by 11 publications

(2 citation statements)

References 16 publications

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“…The only publication found for STZ was a study by Francis et al , using three calves weighing from 34 to 111.5 kg that were dosed with 100 mg kg −1 STZ PO once (Francis, 1949). A serum elimination half-life of 3.9 h was found in this study.…”

Section: Resultsmentioning

confidence: 99%

“…Publications only reporting PK data in graphical form were imported into free online software (WebPlotDigitizer; ) to extract time-concentration data, which were then analyzed using WinNonlin ® (Certara, NC) to calculate the relevant PK parameters by a standard non-compartmental analysis. Publications, which were analyzed in this way are as follows: (Francis, 1949; Rolinski and Halina, 1964; Lapka et al , 1978; Lapka, 1980; Woolley et al , 1980; Woolley and Sigel, 1982; Luthman and Jacobsson, 1983; Palmer et al , 1983; Luthman and Jacobsson, 1985; Murphy et al , 1986; Sepp, 1986; Shoaf et al ., 1987; Chiesa et al , 2012). All data were considered equal; in other words, there was no weighting of data due to differences in sample size or methodology between studies.…”

Section: Methods For Structured Pk Literature Reviewmentioning

confidence: 99%

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Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves

DeDonder

Gehring

Tell

et al. 2016

Anim. Health. Res. Rev.

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The tetracyclines (TTC) and sulfonamides are among the most common residues found in bulk raw milk samples. Detection of drug residues in bulk milk (BM) tankers demonstrates that the product is not suitable for human consumption. Discarding BM with residue-contaminated milk is a waste of a valuable commodity, and a repurposing for consumption at calf ranches is a way to recapture some value. However, if calves consuming milk with drug residues are slaughtered for veal, their meat could contain drug residues. The objective of this review is to provide a residue avoidance strategy for TTC and sulfonamide residues in veal. To determine the pharmacokinetic properties of each drug a structured review of the literature was performed and the study inclusion criteria were that the publication used dairy breed calves, with body weight <330 kg or <6 months of age. The most pertinent parameters were determined to be plasma, tissue elimination half-lives, and systemic bioavailability. The results of this review were integrated with milk and tissue testing levels of quantification and tissue tolerances to formulate a recommended withdrawal interval for calves ingesting this milk. The suggested withdrawal interval of 20 days will ensure that no veal calves will test positive for residues from being fed this milk.

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Section: Resultsmentioning

confidence: 99%