Blood and milk oxidative status after administration of different antioxidants during early postpartum in dairy cows

Rizzo, Annalisa; Pantaleo, Maria Abbondanza; Mutinati, Maddalena; Minoia, Giuseppe; Trisolini, Carmelinda; Ceci, Edmondo; Sciorsci, Raffaele Luigi

doi:10.1016/j.rvsc.2013.07.016

Cited by 17 publications

(16 citation statements)

References 15 publications

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“…At parturition offspring are at risk of oxidative stress as they are exposed to atmospheric concentrations of oxygen; antioxidant enzymes and vitamins in colostrum and milk therefore confer protection against oxidative stress during neonatal development (Castillo et al, 2005;He et al, 2008;Albera & Kankofer, 2009). Finally, malondialdehyde (MDA) is present in milk (Wicheansoni et al, 2007;Suriyasathaporn et al, 2009;Rizzo et al, 2013b), and levels of MDA in maternal blood and milk are correlated in dairy cows (Bouwstra et al, 2008). MDA is highly reactive and may therefore initiate lipid peroxidation in milk and reduce its nutritional quality.…”

Section: (A) Oxidative Shielding In Eutherian Mammalsmentioning

confidence: 99%

Oxidative shielding and the cost of reproduction

et al. 2015

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Life-history theory assumes that reproduction and lifespan are constrained by trade-offs which prevent their simultaneous increase. Recently, there has been considerable interest in the possibility that this cost of reproduction is mediated by oxidative stress. However, empirical tests of this theory have yielded equivocal support. We carried out a meta-analysis to examine associations between reproduction and oxidative damage across markers and tissues. We show that oxidative damage is positively associated with reproductive effort across females of various species. Yet paradoxically, categorical comparisons of breeders versus non-breeders reveal that transition to the reproductive state is associated with a step-change reduction in oxidative damage in certain tissues and markers. Developing offspring may be particularly sensitive to harm caused by oxidative damage in mothers. Therefore, such reductions could potentially function to shield reproducing mothers, gametes and developing offspring from oxidative insults that inevitably increase as a consequence of reproductive effort. According to this perspective, we hypothesise that the cost of reproduction is mediated by dual impacts of maternally-derived oxidative damage on mothers and offspring, and that mothers may be selected to diminish such damage. Such oxidative shielding may explain why many existing studies have concluded that reproduction has little or no oxidative cost. Future advance in life-history theory therefore needs to take account of potential transgenerational impacts of the mechanisms underlying life-history trade-offs.

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Section: (A) Oxidative Shielding In Eutherian Mammalsmentioning

confidence: 99%

Oxidative shielding and the cost of reproduction

et al. 2015

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“…Fortunately, a kit for the quantification of ROS in biological fluids has been developed and validated (Alberti et al., ), allowing their determination through spectrometry, a technique commonly available in most diagnostic laboratories. As ROS is a collective term that includes not only oxygen‐centred free radicals, but also some non‐radical derivates of oxygen, such as hypochlorous acid or hydrogen peroxide (Reilly et al., ), the plasma concentration of ROS is considered an indicator of free radical production (Miller et al., ) and has been reported in several studies regarding the redox status of cattle (Bernabucci et al., , ; Dobbelaar et al., ; Pedernera et al., ; Castillo et al., ; Abuelo et al., , ; Rizzo et al., ).…”

Section: Assessment Of the Oxidative Status Of Dairy Cowsmentioning

confidence: 99%

“…However, it is worth noting that when this supplementation exceeds certain to date unknown level, it can cause harmful effects, such as the increase of odds for mastitis (Bouwstra et al., ,b), because the excessive supplementation with antioxidants can increase the production of ROS (Rizzo et al., ). Oxidative stress is part of a complex system and consequently many confounding factors are likely at play, which explains why some controversial results have been found in different supplementation trials.…”

Section: Benefits Of Antioxidant Supplementationmentioning

confidence: 99%

“…However, a recent study in the Netherlands (Bouwstra et al., ,b) investigated the effects of supplementing high levels of vitamin E and concluded that this practice could increase the odds of clinical mastitis if the animals already have high levels of this antioxidant (>14.5 μ mol/l) at dry‐off. This could be explained by the fact that excessive antioxidants can result in increased ROS (Rizzo et al., ).…”

Section: Benefits Of Antioxidant Supplementationmentioning

confidence: 99%

“…Nevertheless, there is also evidence that excessive supplementation has some detrimental effects, such as increased incidence of mastitis (Bouwstra et al., ,b), because an excess of antioxidants can result in an increase in the production of pro‐oxidants (Rizzo et al., ). Therefore, this review will consider some of the physiological functions of free radicals within the organism and the harmful consequences of their excessive production, alongside with strategies for their prevention and methods for assessment of the redox balance.…”

Section: Introductionmentioning

confidence: 99%

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The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation

Abuelo

Hernández

Benedito

et al. 2014

Animal Physiology Nutrition

197

157

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SummaryDairy cows are especially vulnerable to health disorders during the transition period, when they shift from late pregnancy to the onset of lactation. Diseases at this stage affect not only the animals' well-being, but also cause a major economic impact in dairy farms, because apart from treatment costs, affected cows will not reach their peak milk-producing capacity. The overproduction of reactive oxygen species (ROS) leads to oxidative stress, which has been identified as an underlying factor of dysfunctional inflammatory responses. Supplementation with vitamins and trace elements attempts to minimize the harmful consequences of excessive ROS production, thereby trying to improve animals' health status and to reduce disease incidence. However, results regarding the effects of supplementing antioxidants on dairy cows' health and performance have been inconsistent, because in most cases, the antioxidant potential of the animals was not assessed beforehand and the nutritional strategy planned accordingly. Therefore, reviewing the physiological and harmful effects of ROS production, along with the different options available for assessing the redox balance in dairy cattle and some of the key findings of different supplementation trials, could bring one step forward the on-farm application of determinations of oxidative status for establishing nutritional strategies early enough in the dry period that could improve transition cow health.

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