Blood-based biomarkers can differentiate ulcerative colitis from crohnʼs disease and noninflammatory diarrhea

Burakoff, Robert; Chao, Samuel T.; Perencevich, Molly; Ying, Jay; Friedman, Sonia; Makrauer, Frederick L.; Odze, Robert D.; Khurana, Hema; Liew, Choong‐Chin

doi:10.1002/ibd.21574

Cited by 38 publications

(21 citation statements)

References 32 publications

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“…CD300a has been implicated in ulcerative colitis 53 and its deficiency in mice has been shown to exacerbate gut inflammation. 54 A single nucleotide polymorphism (SNP) encoding a nonsynonymous substitution R94Q in the IgV-like domain of CD300a impairs its capacity to bind PS and PE, and this SNP has been linked to psoriasis susceptibility.…”

Section: Resultsmentioning

confidence: 99%

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Tian

Lee

et al. 2016

Cell Death Differ

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Homeostasis requires the immunologically silent clearance of apoptotic cells before they become pro-inflammatory necrotic cells. CD300f (CLM-1) is a phosphatidylserine receptor known to positively regulate efferocytosis by macrophages, and CD300f genedeficient mice are predisposed to develop a lupus-like disease. Here we show that, in contrast to CD300f function in macrophages, its expression inhibits efferocytosis by DC, and its deficiency leads to enhanced antigen processing and T-cell priming by these DC. The consequences are the expansion of memory T cells and increased ANA levels in aged CD300f-deficient mice, which predispose CD300f-deficient mice to develop an overt autoimmune disease when exposed to an overload of apoptotic cells, or an exacerbated autoimmunity when combined with FcγRIIB deficiency. Thus, our data demonstrates that CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.

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Section: Resultsmentioning

confidence: 99%

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Tian

Lee

et al. 2016

Cell Death Differ

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“…96 In combination with 3 other genes, CD300a has been proposed as a blood-based biomarker that can differentiate ulcerative colitis from Crohn disease and noninflammatory diarrhea. 97 This may help the current serological testing for inflammatory bowel disease that is based on reactivity to bacterial antigens and not host gene expression. 98 In genome-wide expression studies of lymphoblasts compared with normal CD19…”

Section: Disease Relevance Of the Cd300 Moleculesmentioning

confidence: 99%

The CD300 molecules: an emerging family of regulators of the immune system

Borrego

2013

Blood

196

274

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The CD300 family of molecules modulates a broad and diverse array of immune cell processes via their paired activating and inhibitory receptor functions. The description that CD300 molecules are able to recognize lipids, such as extracellular ceramide, phosphatidylserine, and phosphatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activated cells has opened a new field of research. Through their binding to lipids and other ligands, this family of receptors is poised to have a significant role in complex biological processes and in the host response to severe pathological conditions. Indeed, published data have demonstrated their participation in the pathogenesis of several disease states. Moreover, this family of receptors has great potential as targets for diagnosis and therapeutic purposes in infectious diseases, allergies, cancer, and other pathological situations. For instance, one member of the family, CD300a, has been studied as a possible biomarker. Here, a review is provided on the cellular distribution of the human and mouse families of receptors, the stimuli that regulate their expression, their ability to tune leukocyte function and immune responses, their signaling pathways, ligand recognition, and their clinical relevance.

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“…CD300A was proposed, in combination with three other genes (KPNA4, IL1R2, and ELAVL1), as a biomarker that can help to differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea (80). This may benefit the serologic testing for inflammatory bowel disease, which only has sensitivity and specificity ∼80%, to differentiate Crohn's disease from ulcerative colitis; it is based on reactivity to bacterial Ags and not host gene expression (81).…”

Section: Disease Relevancementioning

confidence: 99%

The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine

Zenarruzabeitia

Vitallé

Eguizábal³

et al. 2015

The Journal of Immunology

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The CD300a inhibitory receptor belongs to the CD300 family of cell surface molecules that regulate a diverse array of immune cell processes. The inhibitory signal of CD300a depends on the phosphorylation of tyrosine residues embedded in ITIMs of the cytoplasmic tail. CD300a is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type. The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new light on its role in the modulation of immune functions and in its participation in the host response to several diseases states, such as infectious diseases, cancer, allergy, and chronic inflammatory diseases. This review summarizes the literature on CD300a expression, regulation, signaling pathways, and ligand interaction, as well as its role in fine tuning immune cell functions and its clinical relevance.

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Blood-based biomarkers can differentiate ulcerative colitis from crohnʼs disease and noninflammatory diarrhea

Abstract: Gene expression profiles from blood can differentiate patients with CD from those with UC and from noninflammatory diarrheal disorders.

Cited by 38 publications

References 32 publications

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

The CD300 molecules: an emerging family of regulators of the immune system

The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine

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