Blood Biomarkers and Metabolomic Profiling for the Early Diagnosis of Vancomycin-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis of Experimental Studies

Laou, Eleni; Mavridis, Theodoros; Papagiannakis, Nikolaos; Pais, Gwendolyn; Chighine, Alberto; Chang, Jack; Locci, Emanuela; d’Aloja, Ernesto; Scheetz, Marc H.; Chalkias, Athanasios; Xanthos, Theodoros

doi:10.3390/jpm12091397

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…The quality of human studies was evaluated by Agency for Healthcare Research and Quality (AHRQ) scale on five aspects: selection bias, performance bias, attrition bias, detection bias, and reporting bias ( 25 ). The quality of animal studies was evaluated by the CAMARADES checklist on seven aspects: sample size calculation, random allocation, blinded evaluation of outcomes, appropriate animal model, animal welfare, peer review, and conflict of interest declaration ( 26 ). Three researchers (Liu, Li, Xu) evaluated the studies independently.…”

Section: Methodsmentioning

confidence: 99%

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Liu

et al. 2023

Front. Immunol.

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ObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.ResultsThere were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.ConclusionThere is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.

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Section: Methodsmentioning

confidence: 99%

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Liu

et al. 2023

Front. Immunol.

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“…The pathophysiology of VA-AKI remains uncertain. VA-AKI has a dose‒response relationship, and the incidence of VA-AKI increases with higher vancomycin concentrations and doses [ 13 ]. Vancomycin is mainly excreted through the kidney.…”

Section: Introductionmentioning

confidence: 99%

Association between trough serum vancomycin concentration and vancomycin-associated acute kidney injury and 30-day mortality in critically ill elderly adults

Chen,

Lin,

Weng

et al. 2024

BMC Infect Dis

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Background Vancomycin-associated acute kidney injury (VA-AKI) is the most clinically relevant side effect of vancomycin. The objective of this study was to investigate the association between VTC and VA-AKI as well as 30-day mortality in critically ill elderly adults. Method Elderly patients with trough serum vancomycin concentration records(VTC) in the Medical Information Mart-IV (MIMIC-IV) and eICU databases were retrospectively studied. Results A total of 3,146 critically ill elderly adults were finally enrolled. The incidence of VA-AKI in the elderly population was 76.5%. Logistic regression analysis revealed significant relationships between VA-AKI and various factors, including VTC, comorbidities, and laboratory indicators, and SOFA, and GCS score. For each mg/L increase, the OR for VA-AKI increased by 2.5%. The association between VTC and 30-day mortality was found to be statistically significant (odds ratio (OR): 1.021, 95% CI: 1.010–1.031), P < 0.001). The Restricted cubic splines (RCS) curves revealed that VTC ranged of 19.67 to 35.72 mg/l for AKI and 19.17 to 42.86 mg/l for 30-day mortality exhibit OR with 95% CI above 1, indicating statistically significant associations with an increased risk of AKI and 30-day mortality, respectively. In the subgroup analysis, VTC was identified as a risk factor for VA-AKI in specific patient groups, including white individuals, female patients, those with shock, patients with SOFA > 6, patients with baseline creatinine > 1.2 mg/dl and patients with or without exposed to other nephrotoxic medications. Conclusion This study found the significant association between VTC and the incidence of VA-AKI and 30-day mortality in critically ill elderly adults. The RCS curves indicated concentration ranges for AKI (19.67–35.72 mg/L) and 30-day mortality (19.17–42.86 mg/L), signifying increased risk.

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Effect of antibiotics and low-crude protein diets on growth performance, health, immune response, and fecal microbiota of growing pigs

Gomes,

Duarte,

Saraiva

et al. 2023

Journal of Animal Science

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This study aimed to investigate the effects of diets with and without antibiotics supplementation and diets with 18.5 and 13.0% crude protein (CP) on growth performance, carcass characteristics, disease incidence, fecal microbiota, immune response, and antioxidant capacity of growing pigs. One hundred and eighty pigs (59-d-old; 18.5 ± 2.5 kg) were distributed in a randomized complete block design in a 2 × 2 factorial arrangement, nine replicates, and five pigs per pen. The factors were CP (18.5% or 13.0%) and antibiotics (none or 100 mg/kg tiamulin + 506 mg/kg oxytetracycline). Medicated diets were fed from d 59 to 73. After that, all pigs were fed their respective CP diets from 73 to 87 d. Data were analyzed using the Mixed procedure in SAS version 9.4. From d 59 to 73, pigs fed antibiotics diets had higher (P < 0.05) average daily feed intake (ADFI), average daily weight gain (ADG), gain to feed ratio (G:F), compared to the diets without antibiotics. From d 73 to 87 (post-medicated period), any previous supplementation of antibiotics did not affect pig growth performance. Overall (d 59 to 87), pigs fed antibiotics diets had higher (P < 0.05) G:F compared to pigs fed diets without antibiotics. In all periods evaluated, pigs fed 18.5% CP diets had higher (P < 0.05) ADG and G:F compared to pigs fed 13.0% CP. Pigs fed the 13.0% CP diets had lower (P < 0.05) fecal score and diarrhea incidence than those fed 18.5% CP. Pigs fed 18.5% CP diets had improved (P < 0.05) loin area compared to pigs fed diets with 13.0% CP. At 66 d of age, pigs fed antibiotics diets had lower (P < 0.05) alpha diversity estimated with Shannon and Simpson compared to the pig fed diets without antibiotics. At family level, pigs fed 18.5% CP diets had higher (P < 0.05) relative abundance of Streptococcaceae, and lower (P < 0.05) relative abundance of Clostridiaceae at d 66 and 87 compared with pigs fed 13.0% CP. Pigs fed antibiotics diets had lower (P < 0.05) immunoglobulin G and protein carbonyl concentrations at d 66 compared to the pigs fed diets without antibiotics. The reduction of dietary CP from 18.5% to 13.0% reduced the growth performance and loin muscle area of growing pigs, although it was effective to reduce diarrhea incidence. Antibiotics improved growth performance, lowered diarrhea incidence, improved components of the humoral immune response, and reduced microbiota diversity. However, in the post-medicated period, we found no residual effect on the general health of the animals, and considering the overall period, only G:F was improved by the use of antibiotics.

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Blood Biomarkers and Metabolomic Profiling for the Early Diagnosis of Vancomycin-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis of Experimental Studies

Cited by 4 publications

References 60 publications

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Association between trough serum vancomycin concentration and vancomycin-associated acute kidney injury and 30-day mortality in critically ill elderly adults

Effect of antibiotics and low-crude protein diets on growth performance, health, immune response, and fecal microbiota of growing pigs

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