Blood-Boosting and Gastro-protective influences of Diets Supplemented with Ganoderma lucidum on Indomethacin Gastric Ulcer Induced Rats

Omeonu, Francis; Jonathan, Segun Gbolagade; Chikwem, John; Salami, Adeola Temitope; Gbadamosi, Idayat Titilayo; Asemoloye, Micheal; Aina, Daniel Ayandiran

doi:10.36347/sajb.2020.v08i09.004

Cited by 1 publication

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References 15 publications

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“…This indicates that erythropoiesis, blood clotting, and oxygen transport are all improved. This is in line with Omeonu et al [35] findings on the blood-boosting effects of mushroom-supplemented diet in wistar rats.…”

Section: Fig 1 Daedalea Quercina With Accession Number Mn596945 Colle...supporting

confidence: 92%

Anti-Ulcer and Blood-Boosting Effect of Diet Supplemented with Daedalea quercina from Ogbomoso, Oyo State, South West of Nigeria on Indomethacin Induced Gastric Ulcer In Rats

Omeonu

Jonathan

Salami

et al. 2022

JABB

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Gastric Ulcer is a common ailment in Nigeria, with synthetic drug treatment becoming less effective, hence, herbal remedies are being sought. Daedalea quercina (Dq) has been shown to have significant therapeutic potential, but little is known about its anti-ulcer and blood-enhancing qualities, which is why this study was conducted. Fifty male wistar rats (100-110g; n=5) were divided into two sets of five groups respectively for days 7 and 14 treatments. Blood samples were collected on days 7 and 14 for full blood count. Gastric ulceration was induced in the rats using indomethacin (40 mg/kg p.o) after 24 hours fast on days 8 and 15. Animals were euthanised 4 hours after ulceration, stomachs were excised and analysed for malondialdehyde, sulfhydryl, nitrite, mucin and H+K+-ATPase activity, using standard procedures while tissues from the stomach were harvested and processed for routine histology. Data were expressed as Mean ±SEM, analysed using analysis of variance (ANOVA) and p≤ 0.05 was significant. Haematological indicators were not significantly affected with the treatment. Significant differences were observed with nitric oxide, mucin, sulfhydryl, and hydrogen-peroxide and H+/K+-ATPase. Daedalea quercina treatment groups demonstrated anti-ulcer and blood-boosting activities through the synergistic activities of increased nitrite and antioxidant pathways.

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Section: Fig 1 Daedalea Quercina With Accession Number Mn596945 Colle...supporting

confidence: 92%

Anti-Ulcer and Blood-Boosting Effect of Diet Supplemented with Daedalea quercina from Ogbomoso, Oyo State, South West of Nigeria on Indomethacin Induced Gastric Ulcer In Rats

Omeonu

Jonathan

Salami

et al. 2022

JABB

Self Cite

View full text Add to dashboard Cite

show abstract

Blood-Boosting and Gastro-protective influences of Diets Supplemented with Ganoderma lucidum on Indomethacin Gastric Ulcer Induced Rats

Cited by 1 publication

References 15 publications

Anti-Ulcer and Blood-Boosting Effect of Diet Supplemented with Daedalea quercina from Ogbomoso, Oyo State, South West of Nigeria on Indomethacin Induced Gastric Ulcer In Rats

Anti-Ulcer and Blood-Boosting Effect of Diet Supplemented with Daedalea quercina from Ogbomoso, Oyo State, South West of Nigeria on Indomethacin Induced Gastric Ulcer In Rats

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