Blood buffering in sedentary miniature horses after administration of sodium bicarbonate in single doses of varying amounts

Corn, C.D.; Potter, G.D.; Odom, T.W.; Jenkins, Omer C.

doi:10.1016/s0737-0806(06)81531-5

Cited by 2 publications

(8 citation statements)

References 11 publications

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“…The results of this study suggest that enteral administration of NaHCO 3 to healthy horses causes significant changes in caecal pH, water consumption and certain blood parameters. The effects of orally administered NaHCO 3 on blood constituents in resting horses have been outlined previously . Although experimental designs differ among these studies, the conclusions were similar and in accordance with our results.…”

Section: Discussionsupporting

confidence: 91%

“…With an oral dose of 1.0 g/kg bwt NaHCO3, we were able to induce a metabolic alkalaemia. Similar to Corn et al, Kline et al,Lloyd et al and Rivas et al [10,[13][14][15], our results showed a significant and a persistent increase in serum concentrations of sodium and significant and persistent decrease in serum concentrations of potassium in the NaHCO3 treated horses.…”

Section: Discussionsupporting

confidence: 91%

“…and Rivas et al . , our results showed a significant and a persistent increase in serum concentrations of sodium and significant and persistent decrease in serum concentrations of potassium in the NaHCO 3 treated horses.…”

Section: Discussionsupporting

confidence: 58%

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Effect of orally administered sodium bicarbonate on caecal pH

Taylor

Beard

Douthit

et al. 2013

Equine Veterinary Journal

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Ethical considerationsAll legal and ethical requirements have been met with regards to humane treatment of animals in this study and overseen by the Kansas State University Institutional Animal Care and Use Committee. AcknowledgementsThank you to the Department of Clinical Sciences at Kansas State University for funding this project.The authors would like to thank Dr. James Drouillard and his lab for the use of facilities, without which we would not have completed this project. We would also like to thank the graduate and undergraduate students within the Kansas State University Department of Animal Sciences and Industry, specifically Jessica Jones and Rachel Rusk, for their tireless work in collecting samples.Lastly, we appreciate Dr. Brad White for his statistical advice. 2 SummaryReasons for performing study: Caecal acidosis is a central event in the metabolic cascade that occurs following grain overload. Buffering the caecal acidosis by enterally administered sodium bicarbonate may be beneficial to affected horses. Objectives:To determine the effect and duration of enterally administered sodium bicarbonate (NaHCO 3 ) on caecal pH in healthy horses.Study design: Prospective controlled study using normal horses with caecal cannulas Methods: 9 horses previously fitted with a caecal cannula. 6 horses received 1.0 g/kg bwt NaHCO 3 via nasogastric tube and 3 control horses were given 3 L of water via nasogastric tube. Clinical parameters, water consumption, venous blood gases, caecal pH, faecal pH and faecal water content were measured at 6 hour intervals over a 36 hour study period. Results:Horses that received enterally administered NaHCO 3 had a significantly increased caecal pH that lasted the duration of the study. Treated horses increased their water intake, developed metabolic alcalemia, significantly increased sodium concentrations and significantly decreased potassium concentrations. Conclusions and potential relevance:Enterally administered NaHCO 3 may be beneficial in buffering the caecal acidosis that occurs following an acute carbohydrate overload.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

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Effect of orally administered sodium bicarbonate on caecal pH

Taylor

Beard

Douthit

et al. 2013

Equine Veterinary Journal

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“…The effects of NaHCO, were not observed until the recovery period following an exercise test. In other studies, animals dosed with NaHCO, were in metabolic alkalosis and had increased lactate concentrations during (Roberts et al 1991 ;Ferrante et al 1993) and after a submaximal or intense exercise test (Greenhaff et al 1991 ;Roberts et al 1991 ;Corn et al 1995;Frey et al 1995;Lloyd & Rose, 1995). However, horses on a low fibre, high soluble carbohydrate diet did not exhibit the same effect of increased pH or lactate concentration after exercise with dietary sodium bicarbonate supplementation (Ferrante et al 1992).…”

Section: U S E O F B U F F E R I N G a G E N T Smentioning

confidence: 93%

“…Metabolic responses to NaHCO, loading have been highly consistent among researchers, causing definite acid-base changes and induced metabolic alkalosis. Blood pH, [HCO,-], and standardized base excess (BE) were higher in NaHC0,-dosed horses at rest (Corn et al 1991;Greenhaff et al 1991;Jahn et al 1991;Roberts et al 1991;Hanson et al 1993;Lloyd et al 1993;Frey et al 1995). However, in a subsequent study using Miniature Horses Corn et al (1995) did not observe a significant increase in pH, HC0,-or BE 3 h after dosing with 400 mg/kg.…”

Section: U S E O F B U F F E R I N G a G E N T Smentioning

confidence: 96%

A Review of Recent Research on Nutrition and Metabolism in the Athletic Horse

Hiney

Potter

1996

Nutr. Res. Rev.

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Blood buffering in sedentary miniature horses after administration of sodium bicarbonate in single doses of varying amounts

Cited by 2 publications

References 11 publications

Effect of orally administered sodium bicarbonate on caecal pH

Effect of orally administered sodium bicarbonate on caecal pH

A Review of Recent Research on Nutrition and Metabolism in the Athletic Horse

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