Blood carotene in steatorrhea and the malabsorptive syndromes

Wenger, Julius; Kirsner, Joseph B.; Palmer, Walter L.

doi:10.1016/0002-9343(57)90093-1

Cited by 47 publications

(4 citation statements)

References 26 publications

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“…Die quantitative Stuhlfettanalyse, heute vorwiegend nach der van-de-Kamer-Methode durchgeführt (8), stellt eine Referenzmethode klinischer Malassimilationsdiagnostik dar (4,11,12,19,21) Unsere Daten zeigen jedoch unter Berücksichtigung der Log-Normalverteilung und eines unteren Grenzwertes von 47 ug/dl (x-2a), daß die ß-Carotin-Konzentration einen hochspezifischen Indikator für eine Steatorrhoe darstellt (Spezifität 93%) und damit praktisch (bei erniedrigten Werten) Für die praktische Anwendung in der klinischen Diagnostik sollte jedoch beachtet werden, daß neben der Störmöglichkeit durch Leberkrankheiten insbesondere eine hinsichtlich ß-Carotinoiden defizitäre Ernährungsweise (Karotten, Gemüse), wie sie bei Alkoholikern häufig vorkommt, Anlaß zu falsch-niedrigen Meßwerten geben kann. Bei Carotin-Mangelernährung kommt es nach 1-4 Wochen zu einem Absinken der ß-Carotin-Konzentration im Serum, da eine ß-Carotin-Speicherung (im Gegensatz zum Vitamin A) kaum existiert (3,14,20).…”

Section: Serum (3-carotene: Asimplestatic Laboratory Parameter For the Diagnosis Of Steatorrhoeaunclassified

Serum-β-Carotin: ein einfacher statischer Laborparameter für die Diagnostik der Steatorrhoe

Lembcke¹,

Geibel²,

Kirchhoff³

et al. 2008

Dtsch med Wochenschr

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The value of serum beta-carotene concentration as an indicator of steatorrhoea was investigated in 50 patients with steatorrhoea (fecal fat greater than 7 g/day), 53 controls, and 22 patients with gastrointestinal disease without steatorrhoea. In the control group, beta-carotene concentrations were normally distributed when plotted logarithmically. The mean value was 131 micrograms/dl. The lower limit of normal, based on a 2-SD confidence interval, was 47 micrograms/dl. beta-Carotene concentrations and fecal fat excretion were correlated in a reciprocal, hyperbolic function (r = -0.66). Twenty-nine of the 50 patients with steatorrhoea had beta-carotene concentrations less than 47 micrograms/dl (sensitivity 58%; specificity 93%). Referring to an additional cut-off point of 100 micrograms/dl, beta-carotene concentration had a sensitivity of 88%. These data show that low plasma beta-carotene concentrations (less than 47 micrograms/dl) can be regarded a specific and useful indicator of steatorrhoea and thus obviate fecal fat analysis. Values greater than 47 micrograms/dl, however do not exclude steatorrhoea. Based on a two-step interpretation beta-carotene is thus both a useful screening test for steatorrhoea (with a cut-off point of 100 micrograms/dl) and, more important, a valid, simple, and clinically practical alternative for fecal fat analysis (if values are less than 47 micrograms/dl).

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Section: Serum (3-carotene: Asimplestatic Laboratory Parameter For the Diagnosis Of Steatorrhoeaunclassified

Serum-β-Carotin: ein einfacher statischer Laborparameter für die Diagnostik der Steatorrhoe

Lembcke¹,

Geibel²,

Kirchhoff³

et al. 2008

Dtsch med Wochenschr

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“…This 'nibbling' instead of the normal 'gorging' has been suggested to affect the intermediary metabolism and make the calorie uptake less efficient [50 and 51]. An excessive loss of potential nutrients due to impaired absorption or excessive excretion has been shown for fat as well as for protein absorption and vitamins [52].…”

Section: A Complex Picture Emergesmentioning

confidence: 99%

Cardiac cachexia in early literature: a review of research prior to Medline

Doehner

Anker

2002

International Journal of Cardiology

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| Cachexia has been known to physicians since ancient Greek times as a 'signum mali ominis' in various diseases indicating end stage disease and poor quality of life. Cardiac cachexia is recently receiving growing attention as modern treatment options prevent early death from cardiac events and more patients live with chronic compensated heart failure. Nevertheless, observation and clinical documentation of this condition go back as long as medical science itself. Pioneering studies on the reasons and mechanisms of cachexia were performed several decades ago. These studies provide fundamental insights and guidance towards a better understanding of cachexia. This review presents an overview of early thoughts and milestone studies on metabolic abnormalities and cachexia in chronic heart failure.

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“…Various tests of fat absorption, based on changes in blood level or urinary excretion of fat (Osmon, Zinn & Wharton, 1957;Kabler, Atwood & Schilling, 1959), or a fatsoluble substance (Wenger, Kirsner & Palmer, 1957;McCoord et al, 1948) that has been given by mouth, can be carried out in a matter of hours, rather than days, but unfortunately none has proved as reliable as chemical estimation of faecal fat.…”

Section: Tests Offat Absorptionmentioning

confidence: 99%

The management of chronic or recurrent diarrhoea in childhood

Townley

1969

Postgraduate Medical Journal

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Blood carotene in steatorrhea and the malabsorptive syndromes

Cited by 47 publications

References 26 publications

Serum-β-Carotin: ein einfacher statischer Laborparameter für die Diagnostik der Steatorrhoe

Serum-β-Carotin: ein einfacher statischer Laborparameter für die Diagnostik der Steatorrhoe

Cardiac cachexia in early literature: a review of research prior to Medline

The management of chronic or recurrent diarrhoea in childhood

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