Blood cell parameters as prognostic predictors of disease development for patients with advanced non‑small cell lung cancer

Wang, Leirong; Si, Hongzong; Wang, Jing; Feng, Lingxin; Zhai, Wenxin; Dong, Shenghua; Yu, Zhuang

doi:10.3892/ol.2020.11655

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…Investigations on other cancers con rmed that the lymphocyte to white blood cell ratio (LWR) is associated with an inferior prognosis in many malignancies, such as nasopharyngeal carcinoma, colorectal carcinoma, and lung cancer. [11][12][13] In our previous study, we also con rmed that low preoperative LWR (< 30%) contributed to a high incidence of recurrence for HCC patients after liver transplantation. 14 However, whether LWR can predict the outcomes of patients with HCC after surgical resection is unclear.…”

Section: Introductionsupporting

confidence: 56%

Preoperative lymphocyte to white blood cell ratio predicts the survival of patients with hepatocellular carcinoma after liver resection: A multicenter study

Qin

Zhou

et al. 2022

Preprint

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Background Lymphocytes play a key anticancer role. However, there is little information concerning the prognostic utility of the lymphocyte to white blood cell ratio (LWR) for patients with hepatocellular carcinoma (HCC) after liver resection. Methods The data of patients with HCC who underwent liver resection at 5 centers were retrospectively reviewed. X-Tile software was used to determine the optimal cutoff values of the inflammation-based models. Univariate and multivariate analyses were used to identify the independent risk factors for both recurrence-free survival (RFS) and overall survival (OS). Multivariate Cox proportional hazard models were used to assess the independent risk factors for RFS and OS. Results A total of 1591 patients were included in this study. The multivariate analyses revealed that LWR was an independent risk factor for both RFS (HR = 1.190, 95% CI = 1.037–1.365, P = 0.013) and OS (HR = 1.300, 95% CI = 1.098–1.539, P = 0.002) for HCC patients after liver resection. LWR showed a higher predictive capacity for both RFS and OS than other inflammation-based models for patients with HCC after tumor resection. The 5-year RFS and OS were 42.9% and 60.8%, respectively, for HCC patients with a high LWR, which were significantly higher than those with a low LWR (36.9% for RFS and 49.0% for OS, both P < 0.001). Conclusions Preoperative LWR may serve as a novel marker to predict the survival of HCC patients after liver resection. Low LWR was associated with a high incidence of postoperative recurrence and mortality.

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Section: Introductionsupporting

confidence: 56%

Preoperative lymphocyte to white blood cell ratio predicts the survival of patients with hepatocellular carcinoma after liver resection: A multicenter study

Qin

Zhou

et al. 2022

Preprint

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“…5 In contrast, lymphocytes display completely different behavior and are believed to have anticancer activity; indeed, lymphocytosis itself is considered a favorable prognostic factor. 9 These abnormalities demonstrate a mutual relationship, as reflected in the PLR and NLR parameters. 5,9 Although 7798 their prognostic role of these parameters in NSCLC has been widely discussed in meta-analyses, the authors recommend caution in their interpretation and use in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…9 These abnormalities demonstrate a mutual relationship, as reflected in the PLR and NLR parameters. 5,9 Although 7798 their prognostic role of these parameters in NSCLC has been widely discussed in meta-analyses, the authors recommend caution in their interpretation and use in clinical practice. 10,11 Nevertheless, as the test is widely available and easy to perform, and the results are obtained quickly afterwards, it was included in the present study.…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Significance of Preoperative Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Operated for Non-Small Cell Lung Cancer

Łochowski

Chałubińska-Fendler

Zawadzka

et al. 2021

CMAR

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The aim of the study was to determine the prognostic significance of PLR and NLR ratios in patients operated due to non-small cell lung cancer. Material:The study group consisted of 532 (174 women, 358 men) patients with non-small cell lung cancer (NSCLC) staged IA-IIIA. The mean age was 63.6 years (range 36 to 84 years). Together with platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR), the following factors were included in the statistical analysis: age, sex, smoking history, the number of leukocytes, neutrophils, and platelets, histopathology, T-stage, N-stage, concomitant diseases according to the Charlson Comorbidity Index (CCI), type of operation, adjuvant chemotherapy, and overall survival. Results: Univariate analysis showed an association between the value of PLR and NLR and the length of survival. Multivariate analysis found that the stage of advancement of the neoplastic disease (p=0.00003), adjuvant chemotherapy (p=0.009), CCI > 4 (0.00008), and PLR > 144 (p=0.001) were negative prognostic factors for survival > 2 years; however, this effect diminishes in patients surviving more than 5 years. Conclusion: PLR might serve as a prognostic factor in patients affected by NSCLC with expected two-year overall survival.

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“…Our subtype specific NLR ratio cut offs are within similar ranges from these studies, with these reported NLR cut off ratios ranging from between 1.26 to 2.74 [ 6 , 10 , 12 , 15 ]. The range of cut offs reported is likely indicative of intrinsic differences in the cohorts (such as age, menopause status, geographical location, ethnicity), in line with other differences associated with changes in breast cancer outcomes [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 89%

Peripheral Blood Cell Ratios as Prognostic Indicators in a Neoadjuvant Chemotherapy-Treated Breast Cancer Cohort

et al. 2022

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Breast cancer represents a heterogeneous condition in which the interaction between host immune response and primary oncogenic events can impact disease progression. Ratios of systemic blood-based immunocytes have emerged as clinically-relevant prognostic biomarkers in cancer patients. The NLR (neutrophil-to-lymphocyte ratio) has been shown to be prognostic in a variety of cancers, including breast cancer. However, evaluation of the prognostic value for overall survival (OS) and disease-free survival (DFS) of other key immunocyte ratios—neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-white cell count ratio (NWR), lymphocyte-to-white cell count ratio (LWR), monocyte-to-white cell count ratio (MWR), platelet-to-lymphocyte (PLR)—by breast cancer subtypes in a neoadjuvant chemotherapy (NAC) cohort remains to be fully explored. An NAC-treated breast cancer cohort, comprised of Luminal A, Luminal B, HER2-positive, and triple negative/basal breast cancers, treated at a tertiary referral center (minimum 3-year follow-up), was used to calculate immunocyte ratios and immunocyte cut-off values, calculated with >80% specificity (using decision tree modeling). The association with subtype-specific OS, DFS, and tumor grade was analyzed using cut offs calculated using both receiver operating characteristic curves and decision tree modelling. Decision tree calculated ratios showed that LMR (5.29) and MWR (0.06) were significantly associated with Luminal A OS (p = 0.004 and p = 0.022) and DFS (p = 0.004 and p = 0.022), and Luminal B OS (p = 0.027 and p = 0.008) and DFS (p = 0.005 and p = 0.007). NLR (1.79) and LWR (0.30) were significantly associated with HER2-positive OS (p = 0.013 and p = 0.043). NLR (1.79) and NWR (0.62) were significantly associated with DFS (p = 0.035 and p = 0.021). No significant association we observed between any immunocyte ratio in the triple negative cohort. Our results demonstrate the subtype-specific prognostic value of immunocyte ratios in NAC-treated breast cancer patients. Further validation of immunocyte ratios will provide clinicians with a new prognostic aid for disease management and monitoring.

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Blood cell parameters as prognostic predictors of disease development for patients with advanced non‑small cell lung cancer

Cited by 9 publications

References 41 publications

Preoperative lymphocyte to white blood cell ratio predicts the survival of patients with hepatocellular carcinoma after liver resection: A multicenter study

Preoperative lymphocyte to white blood cell ratio predicts the survival of patients with hepatocellular carcinoma after liver resection: A multicenter study

The Prognostic Significance of Preoperative Platelet-to-Lymphocyte and Neutrophil-to-Lymphocyte Ratios in Patients Operated for Non-Small Cell Lung Cancer

Peripheral Blood Cell Ratios as Prognostic Indicators in a Neoadjuvant Chemotherapy-Treated Breast Cancer Cohort

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