Blood cell progenitors: Insights into the properties of stem cells

Yöder, Mervin C.

doi:10.1002/ar.a.10133

Cited by 13 publications

(6 citation statements)

References 92 publications

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“…However, in the last years a number of publications have provided evidences for a greater plasticity of stem cell commitment and differentiation (Young and Black, 2004). For example, bone marrow cells, including isolated populations of hematopoietic stem cells have been reported to differentiate into muscle, neurons, liver, vascular, lung, intestine and kidney tissue (Yoder, 2004). In addition, it has been shown that stem cells obtained from adult bone marrow not only were able to differentiate into cardiomyocytes but also contributed to restore cardiac function when either injected directly into the injured adult heart (Tomita et al, 1999) or exposed to myocardium via circulation (Orlic et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Research of cardiomyocyte precursors in adult rat heart

Bellafiore

Cappello

et al. 2006

Tissue and Cell

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Recent reports supported the existence of stem cells in adult hearts. However, phenotype and localization of these cells have not been completely described and it is unknown if cardiac regenerative potential differs from one subject to another. The aims of our work were to identify different populations of cardiac stem cells by the analysis of specific markers and to evaluate the expression variability of these markers in 12 adult rat hearts. The expression of CD9, taube nuss and nanog suggests the presence of stem cells from the earliest stages of embryogenesis in adult myocardium. Their different expression could be associated to the degree of stem cell differentiation. CD34 and c-Kit antibodies were used to detect stem cells committed to one or more specific tissue lineages and we found a strong immunoreactivity for CD34 exclusively in the endothelial cells and a low positivity for c-Kit in the interstitium and next to the vessels. Moreover, as c-Kit expression highly differed within all examined hearts, we suggest that cardiomyogenic potential is different among the various subjects. Undifferentiated cells with myogenic-committed phenotype expressing GATA-4 and nestin were found, respectively, in the interstitial and myocardial cells and in few interstitial cells. Therefore, the physiologic turn over of cardiomyocytes may occur in adult hearts as it has been shown in many others organs. The study of myogenic potential could be important to identify markers specific of stem cells in in vivo adult myocardium that may be used to purify these cells and evaluate their regenerative ability.

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Section: Introductionmentioning

confidence: 99%

Research of cardiomyocyte precursors in adult rat heart

Bellafiore

Cappello

et al. 2006

Tissue and Cell

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“…The ontogeny of the hematopoietic system has been investigated in multiple model systems from Drosophila to man, but study of the mouse has provided many fundamental insights due to the ready availability of functional transplantation and colony‐forming assays for hematopoietic stem cells (HSCs) and progenitor cells, respectively . Another advantage of the murine system is the availability of flow cytometry‐based methods to quantitate hematopoietic stem and progenitor cell populations, and to isolate them for study.…”

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confidence: 99%

Hematopoietic stem cell‐independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo

2016

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Steady‐state production of all circulating blood cells in the adult ultimately depends on hematopoietic stem cells (HSCs), which first arise in small numbers beginning at embryonic day (E) 10.5 in large arterial vessels of the murine embryo. However, blood cell synthesis first begins in the yolk sac beginning at E7.25 and consists of two waves of hematopoietic progenitors. The first wave consists of primitive erythroid, megakaryocyte, and macrophage progenitors that rapidly give rise to maturing blood cells of all three lineages. This ‘primitive’ wave of progenitors is followed by a partially overlapping wave of ‘erythro‐myeloid progenitors’, which contain definitive erythroid, megakaryocyte, macrophage, neutrophil, and mast cell progenitors that seed the fetal liver and jump‐start hematopoiesis before the engraftment and expansion of HSCs. These two waves of progenitors that arise in the yolk sac are necessary and even sufficient to sustain the survival of the mouse embryo until birth in the absence of HSCs. They provide key signals to support HSC emergence. Finally, HSC‐independent hematopoiesis also provides long‐lived tissue‐resident macrophage populations that function in multiple adult organs.

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“…Furthermore it has been shown that BM‐derived cells do not stably incorporate into newly formed vessels and only play an auxiliary role in neovascularization . True vasculogenic ability has only been demonstrated for a single cell‐type, designated the endothelial colony forming cell (ECFC) , which cannot be obtained from BM. While the auxiliary angiogenic effects of BM‐MNCs have been demonstrated very consistently in animal models, it is likely that they only occur with BM isolates from comparatively young subjects without comorbidities .…”

Section: Cell Therapy For Clti—the Present State Of Affairsmentioning

confidence: 99%

Cell Therapy for Chronic Limb-Threatening Ischemia: Current Evidence and Future Directions

Teraa

Gremmels

Wijnand

et al. 2018

Stem Cells Translational Medicine

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SummaryCell‐based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre‐clinical and small pilot clinical studies showed promising effects of cell therapy in peripheral artery disease and chronic limb‐threatening ischemia in particular. However, these promising results were not corroborated in larger high quality blinded randomized trials. This has led to a shift of the field towards more sophisticated cell products, especially mesenchymal stromal cells. Mesenchymal stromal cells have some important benefits, making these cells ideal for regenerative medicine, e.g., potential for allogeneic application, loss of disease‐mediated cell dysfunction, reduced production costs, off‐the‐shelf availability. Future high quality and large clinical studies have to prove the efficacy of mesenchymal stromal cells in the treatment of peripheral artery disease. Stem Cells Translational Medicine 2018;7:842–846

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Blood cell progenitors: Insights into the properties of stem cells

Cited by 13 publications

References 92 publications

Research of cardiomyocyte precursors in adult rat heart

Research of cardiomyocyte precursors in adult rat heart

Hematopoietic stem cell‐independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo

Cell Therapy for Chronic Limb-Threatening Ischemia: Current Evidence and Future Directions

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