Blood cells as supercarrier systems for advanced drug delivery

Wang, Shuo; Han, Keqin; Ma, Shuhao; Qi, Xiaojing; Guo, Ling; Li, Xuejin

doi:10.1016/j.medidd.2021.100119

Cited by 18 publications

(11 citation statements)

References 275 publications

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“…Moreover, RBCs can be engineered as drug delivery systems, thanks to their features of biocompatibility, biodegradability, and long-circulating life ( Villa et al, 2017 ). Recently, various types of drug delivery systems based on blood cells have been developed, as well as blood-cell-inspired carriers that mimic the features of native blood cells ( Wang et al, 2022 ). Finally, a new kind of next-generation carrier arising from RBCs has been proposed; this is the case of RBC-derived extracellular vesicles (RBCEVs), which are promising nanosized drug carriers for the intracellular delivery of cargoes ( Biagiotti et al, 2023 ).…”

Section: Rbcs As Natural Carriers For Drugsmentioning

confidence: 99%

Drug transport by red blood cells

Biagiotti,

Perla,

Magnani

2023

Front. Physiol.

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This review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a general introduction about RBC physiology is provided, followed by the presentation of several cases in which RBCs act as natural carriers of drugs. This is due to the presence of several binding sites within the same RBCs and is regulated by the diffusion of selected compounds through the RBC membrane and by the presence of influx and efflux transporters. The balance between the influx/efflux and the affinity for these binding sites will finally affect drug partitioning. Thereafter, a brief mention of the pharmacokinetic profile of drugs with such a partitioning is given. Finally, some examples in which these natural features of human RBCs can be further exploited to engineer RBCs by the encapsulation of drugs, metabolites, or target proteins are reported. For instance, metabolic pathways can be powered by increasing key metabolites (i.e., 2,3-bisphosphoglycerate) that affect oxygen release potentially useful in transfusion medicine. On the other hand, the RBC pre-loading of recombinant immunophilins permits increasing the binding and transport of immunosuppressive drugs. In conclusion, RBCs are natural carriers for different kinds of metabolites and several drugs. However, they can be opportunely further modified to optimize and improve their ability to perform as drug vehicles.

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Section: Rbcs As Natural Carriers For Drugsmentioning

confidence: 99%

Drug transport by red blood cells

Biagiotti,

Perla,

Magnani

2023

Front. Physiol.

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“…Erythrocytes are viewed as natural transport agents for drug delivery because there is abundant intracellular space for drug loading and their physical structure and size can aid in immune cell evasion [ 11 ]. Drug-encapsulated or surface-modified erythrocytes can function as circulating depot systems by protecting the drugs from phagocytosis, resulting in gradual release of drugs into the blood and attenuation of drug-related toxicity [ 52 ]. There have been several successful attempts to mimic the biological functions and physical shape/structure of erythrocytes for drug delivery [ 3 , 10 , 11 ].…”

Section: Resultsmentioning

confidence: 99%

Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat, oxygen and reactive oxygen species for suppressing hypoxic tumors

Kim

Yoon

Kim

et al. 2023

Bioactive Materials

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“…In this regard, biological drug carriers, such as erythrocytes, exosomes, and albumin, are currently being widely studied. Such biological containers have many advantages over synthetic delivery systems: no unwanted physiological response, good biodegradability, and long circulation time [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Platelets as a Platform for Drug Delivery and Cell Trapping

et al. 2023

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The possibility of using magnetically labeled blood cells as carriers is a novel approach in targeted drug-delivery systems, potentially allowing for improved bloodstream delivery strategies. Blood cells already meet the requirements of biocompatibility, safety from clotting and blockage of small vessels. It would solve the important problem of the patient’s immune response to embedded foreign carriers. The high efficiency of platelet loading makes them promising research objects for the development of personalized drug-delivery systems. We are developing a new approach to use platelets decorated with magnetic nanoparticles as a targeted drug-delivery system, with a focus on bloodstream delivery. Platelets are non-nuclear blood cells and are of great importance in the pathogenesis of blood-clotting disorders. In addition, platelets are able to attach to circulating tumor cells. In this article, we studied the effect of platelets labeled with BSA-modified magnetic nanoparticles on healthy and cancer cells. This opens up broad prospects for future research based on the delivery of specific active substances by this method.

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Blood cells as supercarrier systems for advanced drug delivery

Cited by 18 publications

References 275 publications

Drug transport by red blood cells

Drug transport by red blood cells

Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat, oxygen and reactive oxygen species for suppressing hypoxic tumors

Magnetic Platelets as a Platform for Drug Delivery and Cell Trapping

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