Blood chemical changes and renal histological alterations induced by gentamicin in rats

Alarifi, Saud; Al‐Doaiss, Amin A.; Alkahtani, Saad; Al‐Farraj, Saleh A.; Aleissa, Mohammed S.; Aldahmash, Badr Abdullah; Al-Yahya, Hamad; Mubarak, Muhammed

doi:10.1016/j.sjbs.2011.11.002

Cited by 51 publications

(29 citation statements)

References 42 publications

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“…In the current work, serum creatinine levels and BUN were significantly increased in gentamicin group compared with control group. These results are coordinated with other earlier researches (Alarifi et al, ; Bekheet et al, ). Significant reduction in serum creatinine and BUN was observed in gentamicin rats treated with rosmarinic acid, lycopene or combined rosmarinic acid and lycopene as compared with gentamicin group.…”

Section: Discussionsupporting

confidence: 93%

Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat

Bayomy

Elbakary

Ibrahim

et al. 2017

The Anatomical Record

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Gentamicin nephrotoxicity accounts for 10%-15% of all cases of acute renal failure. Several natural antioxidants were found to be effective against drug-induced toxicity. The possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy were evaluated. Sixty-three rats were randomly divided into seven groups named: control, group II received RA 50 mg/kg/day, group III received Lyc 4 mg/kg/day, group IV received Gen 100 mg/kg/day, group V (RA + Gen), group VI (Lyc + Gen), and group VII (RA + Lyc + Gen). At the end of the experiment, kidney functions were estimated then the kidneys were sampled for histopathological, immunohistochemistry, and biochemical studies. Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin. They increased reduced glutathione, glutathione peroxidase, superoxide dismutase, and immunoexpression of the antiapoptotic protein (Bcl2). They also improved the histopathological changes induced by gentamicin. The combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy. Anat Rec, 300:1137-1149, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 93%

Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat

Bayomy

Elbakary

Ibrahim

et al. 2017

The Anatomical Record

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“…The exact mechanism of hepatotoxicity is not well understood yet but it is believed that it increases the production of free radicals which lead to create oxidative stress in the body (Alarifi et al, 2012). Silymarin was chosen for the present study as a standard because of its high antioxidant property and its free radicals scavenging activity (Mosallanejad et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Following aminoglycosides treatment approximately 5-10% patients have to face adverse effects like hepatotoxicity, nephrotoxicity and ototoxicity due to production of free oxygen radicals. Gentamicin produces free oxygen radicals by acting on mitochondria of hepatocytes and accelerates the lipid peroxidation process (Alarifi et al, 2012). From the history of human being polyherbal formulations are in use to cure different ailments.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Qurs-E-Afsanteen on Gentamicin Induced Hepatotoxicity and Oxidative Stress in Rabbits

Aziz¹

2017

PAKJAS

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“…Feeding diet supplemented with 10% of celery, lowered the elevated serum level of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids in rats [3]. Rats were exposure to gentamicin (GM) can induce significant histological alterations in the kidney as well as remarkable blood chemical changes that might indicate marked renal failure [4]. It is well established that rats were injected with gentamicin sulfate (100 mg/ kg/day i.p.)…”

Section: Literature Reviewmentioning

confidence: 99%

Effects of Celery Seed Extracts on Some Haematological and Biochemical Parameters in Albino Rats Treated with Gentamicin

Mustafa

Abdullah

Mahmood

et al. 2019

KJAR

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The present study targeted the influence of orally celery seeds (Apium graveolens) aqueous extract and ethanolic extracts on male albino rats injected with gentamicin intraperitoneally to investigate some hematological and biochemical parameters. Thirty-two male rats were weighing 300-400 gm carried out for the present research, they controlled environmentally. Animals were divided equally and randomly into four groups each of which contained eight rats. First group (control) included normal rats, group2 were given 100 mg/kg B.W. gentamicin (GM) intraperitoneally (IP), group3 (combined group) were given 100 mg/kg B.W. GM and 150 mg/kg B.W. celery seed ethanolic extract orally by needle gavage, and group4 (combined group) were given 100 mg/kg B.W. GM (IP) and celery seeds aqueous extract 150 mg/kg B.W. orally by needle gavage respectively the present study contiued for eight executive days. The results showed that the elevated by GM haematological parameters lowered by the celery seed aqueous extract as compared to the celery seed ethanolic extract group, while the elevated serum malondialdehyde (MDA) and total cholesterol (TC) are decreased in group3 more than they were in the group4, in contrast to that the triglyceride (TG), high density lipoprotein (HDL), low-density lipoprotein (LDL), serum creatinine (CR), serum uric acid (UA), and alkaline phosphatase (ALP) lowered in the group4 from the group 3. The present study concluded that both extracts of celery seeds play a vital biological role, including the improvement effects against the side effect of GM and offering health benefits through decreasing of elevated parameters. Preparations of laboratory animalsMale albino rats (Rattus norvegicus) were purchased from animal house (Zakho University-Iraq) and they were housed in animal house (Biology department of Faculty of science, Soran University, Iraq). The present study was performed thirty-two male albino rats. Animals were weighting about 300 -400 gm. They acclimatized in an environmentally controlled room at constant temperature 22 ± 2 •C on a lighting schedule 12 h light and 12 h darkness, they were maintained at free access to tap water ad libitum they fed at a standard pelleted feed according to Pico Lab. During the experiment the cages were cleaned once a week. Preparation of the dietThe constituents of diet were determined according Pico Lab. Rodent diet 20, with assistance of expert of in Erbil poultry project and Erbil animal diet factory, Iraq, as following; wheat 66.6%, soya 25.6%, oil sun flower 4.4%, lime stone 1.5%, salt 0.63%, methionine 0.156%, lysine 0.244%, choline chloride 0.062%, vit CX lay 0.058%, dicalcium phosphate 0.642%, AZ /1200= 0.080% and trace elements 0.050%. Preparation gentamicin doseGentamicin ampules were purchased in the local pharmaceutical were the patients used them as an antibiotics against disease related with respiratory system, the dose of 80 mg/kg B.W. was determined and injected intraperitoneally (IP) daily for eight executive days. Preparation of celery seeds extra...

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Blood chemical changes and renal histological alterations induced by gentamicin in rats

Cited by 51 publications

References 42 publications

Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat

Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat

Ameliorative Effects of Qurs-E-Afsanteen on Gentamicin Induced Hepatotoxicity and Oxidative Stress in Rabbits

Effects of Celery Seed Extracts on Some Haematological and Biochemical Parameters in Albino Rats Treated with Gentamicin

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