Blood compatibility of photografted hydrogel coatings

Faxälv, Lars; Ekblad, Tobias; Liedberg, Bo; Lindahl, Tomas

doi:10.1016/j.actbio.2009.12.046

Cited by 57 publications

(51 citation statements)

References 38 publications

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“…It may be inferred that ADA‐X‐G hydrogel do not activate the coagulation system to any great extent. Excellent hemocompatibility was demonstrated for several other hydrogels too 23. Our results are consistent with the observations made by other authors.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of alginate dialdehyde cross‐linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft

et al. 2011

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Vascular grafts are devices intended to replace compromised arteries in the body and grafts made of polyethylene terephthalate (PET) fabric have been used mainly for synthetic grafting procedures involving medium to large diameter vascular grafts. Though porosity of the graft permits tissue in-growth, it would lead to bleeding through the graft walls immediately after implantation. So it is essential to seal the pores either by preclotting with patient's own blood or by other sealing materials prior to implantation in order to prevent blood leakage through the graft wall. Biodegradable hydrogel materials are ideal candidates for this purpose. Apart from sealing the pores, they offer biocompatible and low-thrombogenic surfaces when coated on vascular graft. In the present study, a biodegradable hydrogel, derived from oxidized alginate and gelatin, has been deposited on PET grafts by dip coating and were characterized for its efficacy on sealing the pores of the graft. Water permeability in the static and pulsatile conditions, burst strength, in vitro cell culture cytotoxicity, hemocompatibility, and endothelial cell adhesion and proliferation of the coated grafts were investigated. Results showed that the alginate dialdehyde cross-linked gelatin hydrogel was nontoxic, hemocompatible, and was efficient in sealing the pores of the graft. Blood perfusion study showed that when hydrogel-coated grafts were exposed to blood for 30 min, they showed little affinity toward platelets or leukocytes. Hemolytic potential of PET was significantly reduced when it was coated with hydrogel. Improved adhesion and proliferation of endothelial cells were observed when PET grafts were coated with hydrogel. Results also showed that coating with hydrogel did not affect the burst strength of the PET graft.

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Section: Discussionsupporting

confidence: 93%

Evaluation of alginate dialdehyde cross‐linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft

et al. 2011

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“…Homogenous EC layers are normally difficult to produce and have the problem of functional viability in vivo and that of the reliability of cell attachment . Therefore, the generation of self‐assembled monolayers (SAMs) or the attachment of thin polymer layers to the blood contacting surfaces with the aim of reducing non‐specific adsorption of blood proteins, has gained much attention …”

Section: Introductionmentioning

confidence: 99%

Influence of the Molecular Structure of Surface-Attached Poly(N -alkyl Acrylamide) Coatings on the Interaction of Surfaces with Proteins, Cells and Blood Platelets

et al. 2013

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Blood protein adsorption and blood platelet adhesion onto surface-attached poly(alkylacrylamide) networks that exhibit small and systematic variations in chemical composition are investigated. The polymer coatings are generated by depositing a thin layer of benzophenone-group-containing copolymer onto a solid substrate, followed by photo crosslinking and simultaneous surface-attachment. The correlation of the swelling of the obtained surface-attached networks with the adsorption of blood proteins and cellular adhesion is studied. The swollen surface-attached layers are inert to blood proteins and platelet cells. These results suggest that the hydrogel-coated materials are promising candidates for the generation of hemocompatible surfaces.

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“…Under the irradiation of UV, the purpose of improving surface properties can be realized via free radical surfacephotografting polymerization of functional unsaturated monomers. Monomers used in photografting polymerization are generally 2-hydroxyethyl methacrylate (HEMA) [12], glycidyl methacrylate (GMA) [13], N-vinylpyrrolidone (NVP) [14], 2-methacryloyloxyethyl phosphorylcholine (MPC) [15], N,N-dimethylaminoethyl methacrylate (DMAEMA) [16], 3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate (DMAPS), polyethylene glycol methacrylate (PEGMA) [17] (Fig. 3), etc.…”

Section: Photograft Polymerizationmentioning

confidence: 99%

Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

Feng

Zhao

Zhang

et al. 2010

Front. Chem. Eng. China

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Thrombus formation and blood coagulation are serious problems associated with blood contacting products, such as catheters, vascular grafts, artificial hearts, and heart valves. Recent progresses and strategies to improve the hemocompatibility of biomaterials by surface modification using photochemical immobilization and photograft polymerization are reviewed in this paper. Three approaches to modify biomaterial surfaces for improving the hemocompatibility, i.e., bioinert surfaces, immobilization of anticoagulative substances and biomimetic surfaces, are introduced. The biomimetic amphiphilic phosphorylcholine and Arg-Gly-Asp (RGD) sequence are the most effective and most often employed biomolecules and peptide sequence for improving hemocompatibility of material surfaces. The RGD sequence can enhance adhesion and growth of endothelial cells (ECs) on material surfaces and increase the retention of ECs under flow shear stress conditions. This surface modification is a promising strategy for biomaterials especially for cardiovascular grafts and functional tissue engineered blood vessels.

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Blood compatibility of photografted hydrogel coatings

Cited by 57 publications

References 38 publications

Evaluation of alginate dialdehyde cross‐linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft

Evaluation of alginate dialdehyde cross‐linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft

Influence of the Molecular Structure of Surface-Attached Poly(N -alkyl Acrylamide) Coatings on the Interaction of Surfaces with Proteins, Cells and Blood Platelets

Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

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