Blood compatibility of polyethylene oxide surfaces

Lee, Jin Ho; Lee, Hai Bang; Andrade, Joseph D.

doi:10.1016/0079-6700(95)00011-4

Cited by 693 publications

(411 citation statements)

References 137 publications

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“…[15] It forms dense and brush like shell which limits the polymeric micelle interactions and reduces protein adsorption [16] resulting in longer blood circulation time and high blood compatibility. [17] It can be easily functionalized to tether ligands for targeted drug delivery. [18] However, there are still some drawbacks in use of PEG including immunologic response, non-biodegradability of PEG, relatively easy degradation on exposure to oxygen, and unexpected changes in pharmacokinetics of pegylated nanocarriers, it is still one of the most important ingredients which are used in producing nanocarriers.…”

Section: Shell Of Polymeric Micellesmentioning

confidence: 99%

Untitled

Esfahani¹

2017

AJP

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Almost half of the orally administered drugs are poorly soluble in water; therefore they have low absorption in the gastrointestinal (GI) tract. In addition, drugs which are administered orally must remain stable during passing the GI tract, despite different physiologic challenges such as pH changes, and dilution effect. Hence, new methods are needed to increase the solubility of these drugs while making them more stable in the physiologic environment. Polymeric micelles are one of the new nanocarriers which are able to increase the solubility of these drugs while protecting them from pH changes, dilution effect, and biological barriers such as filtration in the spleen or scavenging by the phagocytic system. This article provides some important and basic information including polymeric micelles characteristics, structure, and preparation.

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Section: Shell Of Polymeric Micellesmentioning

confidence: 99%

Untitled

Esfahani¹

2017

AJP

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“…One of the most simple and important techniques is polymer coating using biocompatible polymers such as poly(ethylene glycol) [4], zwitterionic polymers [5][6][7], microphase-separated polymers [8,9], and poly(2-methoxyethyl acrylate) [10]. These approaches can drastically reduce the adsorption of serum proteins.…”

Section: Introductionmentioning

confidence: 99%

Creation of a blood-compatible surface: A novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity

Yoshitomi¹,

Yamaguchi²,

Kikuchi³

et al. 2012

Acta Biomaterialia

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Various polymeric materials have been used in medical devices, including blood-contacting artificial organs. Contact between blood and foreign materials causes blood cell activation and adhesion, followed by blood coagulation. Concurrently, the activated blood cells release inflammatory cytokines together with reactive oxygen species (ROS). We have hypothesized that the suppression of ROS generation plays a crucial role in blood activation and coagulation. To confirm this hypothesis, surface-coated polymers containing nitroxide radical compounds (nitroxide radical-containing polymer; NRP) were designed and developed. The NRP was composed of a hydrophobic poly(chloromethylstyrene) (PCMS) chain in which 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) moieties were conjugated via condensation reaction of the chloromethyl groups in PCMS with the sodium alkolate group of 4-hydroxy-TEMPO. Blood compatibility was investigated by placing NRP-coated beads in contact with rat whole blood. The amount of ROS generated on PCMS-coated beads used as a control increased significantly with time, while NRP-coated beads suppressed ROS generation. It is interesting to note that the suppression of inflammatory cytokine generation by NRP-coated beads was shown to be significantly higher than that of PCMS-coated beads. Both platelet and leukocyte 4 adhesions on the beads were suppressed with increasing extent of the TEMPO component in the polymer. From these results, it is confirmed that the suppression of ROS by NRP prevents inflammatory cytokine generation, which in turn results in the suppression of blood activation and coagulation on the beads.

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“…Poly(ethylene glycol) (PEG) is known as an excellent blocking agent. Because of the nonionic properties, hydrophilicity and large steric-exclusion effect of PEG, 5 PEGylated surfaces and nano-and microscale particles show excellent non-fouling properties with various molecules 6 and high-dispersion stabilities, [7][8][9] respectively. Furthermore, in our recent studies, we discovered that PEGylation improves the functioning of immobilized proteins on solid surfaces and particles.…”

Section: Introductionmentioning

confidence: 99%

Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly(ethylene glycol) tethered-chain layer

Kubota

Yoshimoto

Yuan

et al. 2011

Polym J

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INTRODUCTIONProtein-immobilized substrates have been widely used in several applications for biosensing and bioseparation. Many kinds of sensors have been based on changes in colorimetric, fluorometric or luminometric signals derived from the immunoreactions of protein-immobilized sensor chips and particles. 1-4 Protein-immobilized substrates, such as column packings and magnetic beads, have also been used as selective materials that can rapidly and simply separate target biomolecules in solution.In the development of high-performance materials for biosensing and bioseparation, an effective blocking treatment is important to decrease nonspecific adsorption onto the surfaces of protein-immobilized substrates and to increase the dispersion stability of substrate particles. Poly(ethylene glycol) (PEG) is known as an excellent blocking agent. Because of the nonionic properties, hydrophilicity and large steric-exclusion effect of PEG, 5 PEGylated surfaces and nano-and microscale particles show excellent non-fouling properties with various molecules 6 and high-dispersion stabilities, 7-9 respectively. Furthermore, in our recent studies, we discovered that PEGylation improves the functioning of immobilized proteins on solid surfaces and particles. For example, the antigen-binding efficiencies of an anti-C-reactive protein antibody-immobilized gold sensor surface 10 and anti-ferritin antibody-immobilized latex particles 11 were improved by the co-immobilization of densely packed PEG layers, consisting of sulfhydryl-terminated PEGs and oligoamine-terminated PEGs. The substrate reactivity of glucose dehydrogenase-immobilized gold nanoparticles was improved by the co-immobilization of PEG/polyamine block copolymer, 8 and lipase/PEG-polyamine/glucose dehydrogenaseimmobilized gold nanoparticle hybrids showed almost the same initial enzymatic activity after five repeated thermal treatments at 58 1C for 10 min. 12 These results indicate that the co-immobilization of PEG

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Blood compatibility of polyethylene oxide surfaces

Cited by 693 publications

References 137 publications

Untitled

Untitled

Creation of a blood-compatible surface: A novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity

Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly(ethylene glycol) tethered-chain layer

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