Blood Concentrations of Selenium, Zinc, Iron, Copper and Calcium in Patients with Hepatocellular Carcinoma

Wang, Chin-Thin; Chang, Wei-Tun; Tzu-Ming, Pan; Wang, Ren-Tse

doi:10.1515/cclm.2002.196

Cited by 21 publications

(13 citation statements)

References 17 publications

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“…With the search strategy stated before, 9 relevant records were included in our meta-analysis and data were extracted (Figure 1) [11, 12, 16, 17, 19–21, 23, 24]. Table 1 summarized the characteristics of the 9 enrolled studies.…”

Section: Resultsmentioning

confidence: 99%

“…The following articles affirm the relationship between Se concentration and HCC. A matched-case-control study revealed lower blood Se levels among HCC patients [11]. There is another report on the obvious correlation relationship between low Se level and HCC in Korean hepatoma patients [12].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have investigated the relationship between Se level and HCC risk [11–21]. Yu et al [19, 22] found that there was asignificant inverse correlation between the levels of blood Se and HCC risk, while others have not demonstrated this [13].…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Zhang

Bi²,

Liu

et al. 2016

Oncotarget

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Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method. Heterogeneity was assessed by using the I2 index. Publication bias was evaluated by Begg's Test analysis. Pooled analysis indicated that patients with HCC had lower Se levels than the healthy controls [standardized mean difference (SMD)= −1.08, 95% confidence intercal (CI) = (−0.136, −0.08), P < 0.001]. Further subgroup analysis showed this effect to be independent of the study design, race or sample collection. In conclusion, this meta-analysis suggested an inverse correlation between Se level and the risk of HCC in humans patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Zhang

Bi²,

Liu

et al. 2016

Oncotarget

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“…More than 25% of the enzymes in the body need to be activated by metal ions to carry out their metabolic functions. [6] Bioelements e.g. Copper and zinc are involved in vital biochemical activities like different redox and free radical formation and in maintaining cellular proton homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Salivary copper and zinc levels in oral pre-malignant and malignant lesions

Ayinampudi

Narsimhan

2012

J Oral Maxillofac Pathol

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Recent technological advances have made saliva as a tool for diagnosis of many things; among them are hormone imbalances, liver function, immunodeficiency and even cancer.Aim:The present study was done to evaluate the levels of copper and zinc and copper/zinc ratio in saliva of premalignant and malignant lesions of oral cavity, because of the anatomical proximity of the saliva to both premalignant and malignant oral neoplasms.Materials and Methods:The levels of copper and zinc were estimated in the saliva of 5 patients with oral submucous fibrosis, 5 patients with oral leukoplakia, 5 patients with oral lichen planus and 10 patients with oral squamous cell carcinoma of oral cavity using inductively coupled mass spectrometry (ICP- MS). The values were compared with 6 normal age and sex matched control subjects.Results:There was significant difference of the mean salivary copper and zinc levels of premalignant and malignant lesions when compared to the normal controls. In oral cancer patients there was significant difference in the copper levels according the histodifferentiaton in squamous cell carcinoma. Within the premalignant group the copper levels were more in the oral sub mucous fibrosis when compared to the leukoplakia and lichen planus. Copper zinc ratio decreased in premalignant and malignant group when compared to the normal group.Conclusions:Saliva may be used as a potential diagnostic tool, which can be efficiently employed to evaluate the copper and zinc levels in pre malignant and malignant lesions of oral cavity. Key words: Copper, inductively couples mass spectrometry, leukoplakia, lichen planus, oral squamous cell carcinoma, oral submucous fibrosis, saliva, zinc

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“…While there is no proven influence of specific nutrients on risk of HCC, micronutrients may play a role 3,76–81 . Selenium is an essential micronutrient required for selenium‐containing anti‐oxidant enzymes such as superoxide dismutase.…”

Section: Prevention Of Nonviral Liver Disease‐related Hccmentioning

confidence: 99%

Prevention of hepatocellular carcinoma in nonviral‐related liver diseases

Fan

Farrell

2009

J of Gastro and Hepatol

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Although chronic infection with hepatitis B virus and/or hepatitis C virus are the most important risk factors for hepatocellular carcinoma (HCC) worldwide, other causes of cirrhosis can also lead to HCC. Given the high prevalence of alcoholism and the worldwide obesity epidemic, the relevant importance of nonviral liver disease-related HCC is expected to increase in the future. Some evidence supports mechanistic interactions between host or environmental factors and chronic viral hepatitis in the development of HCC. For example, food-and water-borne carcinogens have contributed to unusually high rates of HCC in parts of China and sub-Saharan Africa. With some of these conditions, appropriate public health measures to reduce the population's exposure to known etiologic agents, or early therapeutic intervention for 'at-risk' individuals before development of cirrhosis (e.g. hereditary hemochromatosis) can prevent HCC. Community-based programs to discourage and deal with excessive alcohol intake, to promote tobacco smoking awareness, to avoid exposure to aflatoxin and other food toxins, and measures to reduce the pandemic of obesity and diabetes are vital for effective interruption of the rising tide of HCC from nonviral liver disease.

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Blood Concentrations of Selenium, Zinc, Iron, Copper and Calcium in Patients with Hepatocellular Carcinoma

Cited by 21 publications

References 17 publications

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Salivary copper and zinc levels in oral pre-malignant and malignant lesions

Prevention of hepatocellular carcinoma in nonviral‐related liver diseases

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