Blood Cu/Zn Ratio in Children of School Age, Living in Malaria Endemic Area in Abidjan (Côte D'ivoire)

Abstract

Background: Food intake contains various nutrients which the loss or destruction are exogenous factors of oxidative damages in our body, aggravated by infectious diseases. Blood ratio Cu/Zn is an indicator about the pool of defenses anti oxidizing to measure damage oxidative. The present study aimed to investigate the blood ratio Cu/Zn an indicator of pool of oxidative stress and eating risk factors in children school age, living in malaria endemic area.Methods: A total of 113 participants, aged 5-14 years with a mean age about 9.5 ±2 were submitted to the study. Malaria diagnosis was based on clinical grounds as the feverish condition (axillary temperature 37°C) and confirmed by laboratory test. A survey was conducted to screen children eating habits, and conjointly blood ratio Cu/Zn analyzed by atomic absorption spectrometry. Results:We have noted a high value of the Cu/Zn ratio in malarial children, as compared to controls (p < 0.001). This ratio in both groups was highest compared to the normal values (< 1), and showed an acute value in course of parasitemia. Elsewhere, it was identified eating risk factors in all children. Conclusion:Children of school age in high endemic zone of malaria in Côte d'Ivoire are exposed to the damage of stress oxidative. Thus, eating habits and their interaction with the parasite growth should be analyzed, to correct the states of stress by monitoring down the ratio copper/zinc.

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

“…Although Laine et al (2020), in middleaged and older men, suggested that the serum Cu level alone might be a better marker for future risk of an infection [13], other authors believe that the Cu/Zn ratio is a wellestablished feature of infections [14], including parasitic infections, such as Schistosoma mansoni, Enterobious vermicularis, and Trypanosoma cruzi infections and in giardiasis [15] or amebiasis [15,16] and tuberculosis (TB) [14,17]. The significantly higher Cu/Zn ratio at baseline in giardiasis and amebiasis [16], malaria [18], and TB [19] returned to normal after therapy. Furthermore, this Cu/Zn ratio has a diagnostic value in several human disorders [14].…”

Significance of serum copper zinc ratio in smear negative pulmonary tuberculosis cases in Rohilkhand region

“…Cu/Zn ratio serves to be an important indicator to assess the level of oxidative stress in case of infectious disease 4,5 and was found to be significantly higher in the serum of tuberculosis patients in several studies. [6][7][8][9][10] Though various studies has been conducted worldwide regarding the role of serum Cu/Zn ration in active pulmonary tuberculosis but very less studies were done from north Indian population and till date no studies was reported on smear negative pulmonary tuberculosis patients.…”

Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire

“…Among these micronutrients, zinc and copper play an important role in the proliferation and differentiation of cells of innate and acquired immunity [9]. Moreover, the Cu / Zn ratio is an indicator for assessing the level of oxidative stress in the case of infectious diseases in general [10, 11]. These two micronutrients play an essential role in resistance to certain infectious diseases like tuberculosis [12].…”