Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Borelli, Sueli Donizete; Mazzola, Jocimara Costa; Matta, Alessandra Cristina Gobbi; Takemoto, Angélica Yukari; Bértoli, Marta

doi:10.5581/1516-8484.20130126

Cited by 10 publications

(12 citation statements)

References 6 publications

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“…Indeed, 57.1% of the discard rate was associated with HBV, followed by HIV (21.4%), HCV (7.1%), syphilis (10.7%) and malaria (3.6%) (Figure 1). A 57% rate of discard units due to HBV infection herein was consistent with other reports such as in Brazil with 52.5% of discarded blood units due to HBV seropositivity [26]; two additional studies indicated HBV reactivity that reached up to 54.8% [27] and 71.3% [28] of discarded blood units, confirming the high prevalence of this virus in Brazil [27].…”

Section: Discussionsupporting

confidence: 79%

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Bonja¹,

Hussein²,

Alemu³

et al. 2017

Int J Blood Transfus Immunohematol

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Aims: Millions of lives are saved each year through blood transfusion but a safe blood supply is a critical component of health care to prevent the spread of blood-borne infectious diseases. Therefore, it is essential to assess the prevalence and identify the most common culprit and risk in transfusion services. Methods A cross-sectional study was conducted from April 2015 to May 2015 at the Hawassa blood bank center. Blood donors who donated blood for transfusion purposes were considered for the study. Whole blood was collected and serum was separated from each donor. The sera were used for examination of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis. Thick film was prepared and stained using Giemsa for malaria detection. Results: A total of 384 blood donors were screened during the study period. Among these donors, 67.2% (258) were males and 32.8% (126) were females. The overall prevalence of transfusion transmitted infections (TTI) was 28 out of 384 (7.29%) apparently healthy donors. and malaria was 6 (1.6%), 16 (4.2%), 2 (0.5%), 3 (0.8%) and 1 (0.3%) respectively. Two out of 384 (0.5%) had co-infections with HIV-HBV 1 (0.26%) and HBV-HCV 1 (0.26%). A 1:14 ratio (7.14%) of the blood collected was discarded only due to the presence of TTI. The highest discard rate was recorded from HBV infected units 57.1%, followed by HIV 21.40%, syphilis 10.7%, HCV 7.10%, and malaria 3.60%. Overall, TTIs were found in males (7.8%), married (2.5%), rural (8%), private/NGO employed donors (28.6%), 45-54 age group (20%), and in replacement/family donors (16.1%) (p = 0.039). Conclusion: The prevalence of TTIs in the Hawassa blood bank center was significantly high. HBV infection was the major cause for TTIs. Recommendations: Overall, effective clinical and laboratory screening of blood donors is essential. Proper treatment of TTI positive cases and a good donor selection program will help to reduce the prevalence of TTIs in donor units. Blood bank programs should give much more consideration in screening and diagnosis of HBV which is the main TTI that causes a high discard rate of blood.

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Section: Discussionsupporting

confidence: 79%

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Bonja¹,

Hussein²,

Alemu³

et al. 2017

Int J Blood Transfus Immunohematol

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“…36 For this study, the prevalence of syphilis was 0.41% which reinforces similar findings in the study of Borelli et al. 37 at the Blood Center of Maringá, Paraná. On the other hand, the positivity rate for the pathology in Guarapuava (PR) was 2.1%, so a higher rate than that reported in the current study.…”

supporting

confidence: 91%

“…Research in other states of blood centers also showed a high positivity rate for syphilis testing, as well as in the Brazilian states of Amazonas, São Paulo and Sergipe. 37 Regarding the prevalence of syphilis, which in this study was 0.41% and hepatitis B (0.77%), together have demonstrated a high disability rate serologic, corroborating studies by Rodriguez et al, 38 Salles et al, 39 Carrazone et al, 22 and data obtained from the National Health Surveillance Agency. 40 The prevalence of hepatitis B and syphilis as the main pathologies associated with serological screening may be linked to the fact that currently the population has a cumulative effect of behavioral risks.…”

supporting

confidence: 91%

Prevalence of serological inability of blood donors in regional blood center of Montes Claros, Minas Gerais Prevalência de inaptidão sorológica dos doadores de sangue no hemocentro regional de Montes Claros, Minas Gerais

Aguiar

Xavier

Magalhães

et al. 2016

R. pesq. cuid. fundam. online

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ResumoOBJETIVO: estimar a prevalência da inaptidão sorológica dos doadores de sangue no Hemocentro Regional de Montes Claros, no período de 2009 a 2013. MÉTODOS: trata-se de um estudo transversal, de caráter exploratório, através da coleta de dados retrospectivos, que envolveu 2.101 doadores inaptos sorologicamente. O estudo foi aprovado pelo CEP da Fundação Hemominas nº381/2014. RESULTADOS: do total de 82.743 candidatos aptos para a coleta de sangue, 2.101(2,5%) apresentaram testes sorológicos reativos, porém apenas 1.434 (1,9%) confirmaram o resultado através da coleta de 2ª amostra. Dentre as doenças pesquisadas, houve a seguinte distribuição de prevalência: hepatite B (anti-HBc) com 0,77% doadores em relação ao total dos aptos; sífilis (0,41%); Chagas (0,40%); e demais apresentaram valores abaixo de 0,08%. CONCLUSÃO: concluímos que em comparação com outros estudos, verificou-se que a prevalência de inaptidão sorológica em nosso hemocentro é semelhante, mostrando que as medidas adotadas são seguras.DESCRITORES: Sorologia; Doadores de Sangue; Doenças Transmissíveis.

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“…Compared with the prevalence of other diseases with mandatory notification at blood centers, our findings presented rates similar to those observed for hepatitis C virus (HCV) and hepatitis B virus (HBV) and higher than the rates observed for human immunodeficiency virus (HIV) and Chagas disease (10).…”

mentioning

confidence: 61%

Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission

et al. 2015

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dBlood donor samples (1,007) were assessed for anti-phenolic glycolipid 1 (PGL-1) IgM antibodies and Mycobacterium leprae DNA presence, which had 3.8% and 0.3% positivity, respectively. After a 5-year follow-up period, six individuals with positive markers developed leprosy, raising the hypothesis that asymptomatic infection among blood donors may be an undisclosed mode of leprosy transmission via transfusion. Leprosy is one of the oldest infectious diseases known to affect humans and remains a public health issue, particularly in Brazil, which accounts for almost all new cases detected in the Americas (1).Untreated leprosy patients are considered the main source of transmission. However, the dichotomy between the highly effective treatment and the occurrence of new cases among people without previous contact with patients indicates that other infectious sources must be investigated (2).The majority of exposed individuals will not develop the disease, although cumulative evidence demonstrates widespread dissemination of bacilli in regions where leprosy is endemic, strengthening the hypothesis that asymptomatic individuals are involved in the Mycobacterium leprae chain of transmission (3).Serological reactivity to M. leprae antigens has been used as an immunological marker for exposure and infection (4). Seropositivity for antibodies against phenolic glycolipid 1 (PGL-1), M. leprae-specific cell surface antigenic molecule has been correlated to a greater chance for later onset of leprosy among household contacts of leprosy patients (5).Studies regarding the detection of M. leprae DNA in peripheral blood samples are scarce. It has recently been suggested that whole-blood nested-PCR amplification could be used for early diagnosis of leprosy (6) and that the presence of M. leprae DNA in peripheral blood may be associated with bacillary migration and a high risk for disease onset (7).There are no published data on the assessment of randomly selected healthy blood donors for any kind of M. leprae marker. Therefore, this is the first epidemiological study to assess donor blood samples for the presence of antibodies against M. leprae and bacillary DNA through enzyme-linked immunosorbent assay (ELISA) and real-time PCR, respectively.Subjects were screened from a population of 1,035 blood donors at the regional blood bank of Uberlandia, Minas Gerais, Brazil. All subjects had normal dermatoneurological clinical examinations, and 28 people who reported prior contact with leprosy patients were excluded from the study. The reported new-case detection rate in the Uberlandia region was 11 per 100,000 population.A total of 1,007 peripheral blood samples were assessed for the presence of anti-PGL-1 antibodies and M. leprae DNA. Indirect ELISA against M. leprae native PGL-1 molecule was applied to detect specific IgM antibodies in serum samples, according to previously described methodology (4). Detection of DNA was performed with a species-specific TaqMan primer/probe assay targeting the repetitive region RLEP element of disperse...

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Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Cited by 10 publications

References 6 publications

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Prevalence of serological inability of blood donors in regional blood center of Montes Claros, Minas Gerais Prevalência de inaptidão sorológica dos doadores de sangue no hemocentro regional de Montes Claros, Minas Gerais

Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission

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