Blood endothelin-1 levels before and after carotid endoarterectomy for atherosclerotic stenosis

Properzi, Giuliana; Francavilla, Felice; Bellini, Cesare; D'Abrizio, Piera; Mangiacotti, Bambina; Ferri, Claudio; Spartera, C; Santucci, A.; Francavilla, Sandro

doi:10.1016/s0021-9150(00)00445-7

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Increased ET-1 levels were reported in the ED patients with or without VRFs and in the patients with overt vascular disease 45293031. The blockade of ETa receptors improved the endothelial function in the patients with early atherosclerosis, suggesting a pathogenetic role of increased ET-1 levels in endothelial dysfunction 32.…”

Section: Discussionmentioning

confidence: 95%

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

et al. 2014

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The number of the circulating angiogenic cells (CACs) and colony forming units (CFUs) derived from cultured circulating mononuclear cells (MNCs) represents a laboratory surrogate for endothelial cell repair ability. The serum of men with erectile dysfunction (ED) and vascular risk factors (VRFs) showed an increased level of endothelial cell damage/dysfunction markers and reduced the numbers of CACs and CFUs derived from the cells of healthy men. We analyzed whether treating men with ED and VRFs with the selective phosphodiesterase type 5 inhibitor tadalafil improved the endothelial cell repair ability and reduced the levels of the serum markers of endothelial cell damage/dysfunction. MNCs from healthy men were cultured with 20% serum from 36 ED patients to obtain CACs and CFUs. The ED patients were evaluated before and after 4 weeks of treatment with tadalafil (20 mg every other day) or with a placebo. The tadalafil treatment improved erectile function (P = 0.0028), but had no effect on the inhibitory effects of serum from ED patients on the CACs and CFUs derived from healthy men. The levels of endothelin-1 (P = 0.011) and tissue type plasminogen activator (P = 0.005) were reduced after treatment compared to baseline and those of the placebo group, whereas no changes were observed in the E-selectin levels. The tadalafil treatment in the ED patients with VRFs resulted in only a modest effect on the laboratory measures of the endothelial cell damage/dysfunction and repair ability. The proposed beneficial effect of phosphodiesterase type 5 inhibition on vascular homeostasis requires further analysis.

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Section: Discussionmentioning

confidence: 95%

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

et al. 2014

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“…Atherosclerosis is a pathologic condition that directly affects obesity and overweight, and is associated with the thickening of the inner layer of vessels caused by fat deposits and platelets (1). The progression of atherosclerosis disrupts the blood supply to the brain and other organs (2). A major function of vascular endothelial cells is the secretion regulation of growth factors such as VEGF, which plays a key role in the process of blood supply and angiogenesis, and is negatively correlated with obesity and atherosclerosis (3).…”

Section: Introductionmentioning

confidence: 99%

Effects of Eight-Week Resistance Training in Different Environmental Conditions on Arterial Factors in Overweight Men

Kamankesh¹,

Tadibi²,

Behpoor³

et al. 2019

J Clin Res Paramed Sci

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Background:The present study was conducted to investigate the effects of eight weeks of resistance training in different environmental conditions on arterial factors in overweight men. Methods: The present study was conducted in Kermanshah, Iran, on thirty overweight males with a mean body mass index (BMI) of 27.4 ± 1.57 kg/m 2 , who voluntarily participated in this study. The subjects were randomly divided into a hypoxic and a normoxic resistance training group and a hypoxia exposure group, and performed the training protocols for eight weeks. Vascular endothelial growth factor (VEGF), high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC) and triglyceride (TG) were measured before and after performing the intervention. Results: The results showed a significant increase in the level of VEGF in all the three groups (P < 0.05). Significant differences were also observed between the groups in terms of changes in VEGF (P < 0.05). In the hypoxic resistance training group, HDL increased and LDL, TC and TG significantly decreased (P < 0.05). No significant changes were, however, observed in lipid profile in the hypoxia exposure and normoxic resistance training groups. Conclusions: The present findings suggest that hypoxic and normoxic resistance trainings and hypoxia exposure positively affect the level of VEGF, and only the hypoxic resistance training could improve lipid profile in overweight subjects. Hypoxic resistance training is concluded to be a more effective method for improving arterial factors in overweight men.

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Amlodipine treatment decreases plasma and carotid artery tissue levels of endothelin-1 in atherosclerotic rabbits

et al. 2011

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Blood endothelin-1 levels before and after carotid endoarterectomy for atherosclerotic stenosis

Cited by 4 publications

References 26 publications

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

Effects of Eight-Week Resistance Training in Different Environmental Conditions on Arterial Factors in Overweight Men

Amlodipine treatment decreases plasma and carotid artery tissue levels of endothelin-1 in atherosclerotic rabbits

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