Blood eosinophils may predict radiographic sinus opacification in patients with chronic rhinitis

Oh, Seung Yong; Hwang, Junho; Ryu, Yoon-Jong; Won, Jun Yeon; Kwon, Seungwon; Lee, Woo Hyun

doi:10.1002/alr.22270

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…Therefore, peripheral blood eosinophil count has been incorporated into clinical prediction models by other studies. For example, peripheral blood eosinophil count is significantly associated with chronic rhinosinusitis in patients with chronic rhinitis ( 25 ). Peripheral blood eosinophil count less than 0.144 × 10 9 /L or 2% can predict a longer hospital length for patients who were admitted to the hospital with acute exacerbations of chronic obstructive pulmonary disease ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood eosinophil and classification of residual hematoma help predict the recurrence of chronic subdural hematoma after initial surgery

Chen

Shao

2022

Front. Surg.

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Chronic subdural hematoma (CSDH) is a common type of intracranial hemorrhage in neurosurgical practice, whose incidence has increased markedly in recent years. However, CSDH still troubles clinicians with a high postoperative recurrence rate. The presence of eosinophils has been confirmed in some CSDH surgical specimens. Furthermore, postoperative residual hematoma has not been classified, and its association with the recurrence of CSDH remains unknown. The present study aimed to test the hypothesis that the peripheral blood eosinophils and the classification of postoperative residual hematoma are significant for the prediction of CSDH recurrence after burr-hole surgery. A retrospective review of 258 CSDH patients who received burr-hole surgery was performed. A complete blood picture with differential count was taken before surgery. Clinical, laboratory, and radiographic factors predicting CSDH recurrence were identified in univariable and multivariable analyses. Univariable analysis showed that the percentage of eosinophils, peripheral blood eosinophil count <0.15 × 109/L, gradation and separated types, postoperative volume of the residual cavity ≥70 ml, residual air volume ≥28 ml, residual hematoma volume ≥55 ml, residual hematoma width ≥1.4 cm, postoperative midline shift ≥5.6 mm, postoperative brain re-expansion rate <41%, postoperative low-density type, and postoperative high-density type correlated with the recurrence of CSDH. Multivariable analysis, however, showed that peripheral blood eosinophil count <0.15 × 109/L, gradation and separated types, preoperative midline shift ≥9.5 mm, postoperative brain re-expansion rate <41%, postoperative low-density type, and postoperative high-density type are independent predictors for the recurrence of CSDH. We expect that peripheral blood eosinophils and the classification of postoperative residual hematoma may facilitate our understanding of the recurrence of CSDH after initial surgery.

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Section: Discussionmentioning

confidence: 99%

Peripheral blood eosinophil and classification of residual hematoma help predict the recurrence of chronic subdural hematoma after initial surgery

Chen

Shao

2022

Front. Surg.

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“…Blood eosinophil has been previously related to disease burden and outcomes of CRS, and asthma and eosinophilic granulomatosis with polyangiitis. [9][10][11][12][27][28][29] Despite studies indicating distinct endotypes in CRS patients, 30,31 our study aimed to understand the associations between uncontrolled disease and inflammatory patterns. We analyzed potential predictors in Chinese CR-SwNP patients and subgroups classified based on the site of eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

“…After adjusting for confounding factors, we found that blood eosinophilia was a predictor of uncontrolled disease after surgery in patients with CRSwNP. Blood eosinophil has been previously related to disease burden and outcomes of CRS, and asthma and eosinophilic granulomatosis with polyangiitis 9–12,27–29 …”

Section: Discussionmentioning

confidence: 99%

“…Although CRSwNP is a heterogeneous disorder characterized by distinct combinations of T‐cell and granulocyte responses, the eosinophilic feature is recognized as a pivotal trait of the disease and eosinophils are useful biomarkers in clinical practice for monitoring disease severity and control in CRSwNP patients 2–4 . Both mucosal and blood eosinophilia are associated with disease severity and postsurgical recurrence in CRSwNP patients 5–13 …”

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confidence: 99%

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Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia

Liao

Guo

et al. 2020

Int Forum Allergy Rhinol

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BackgroundIn this study we aimed to identify inflammatory patterns and predictors associated with clinical outcomes in chronic rhinosinusitis with nasal polyps CRSwNP patients with different blood and tissue eosinophilia Methods A total of CRSwNP patients were enrolled and the expression of biomarkers together with eosinophil and neutrophil counts in nasal polyps were analyzed in a subset of patients Patients were stratified on the basis of blood ≥ × /L and tissue > eosinophilia Logistic regression models were applied to identify predictors of uncontrolled disease at least year a er surgery Uncontrolled disease was defined according to the European Position Paper on Rhinosinusitis and Nasal Polyps Results Among patients showed inconsistent blood and tissue eosinophilia In CRSwNP patients subjects with concomitant blood and tissue eosinophilia group showed marked mucosal type inflammation characterized by high levels of interleukin IL -IL-and eotaxin-whereas subjects with normal blood and tissue eosinophil levels group demonstrated significant local neutrophilic inflammation with high expression of granulocyte colony-stimulating factor and subjects with selec-tive tissue eosinophilia group showed intermediate and mixed eosinophilic and neutrophilic inflammation Subjects with isolated blood eosinophilia group showed low expression of vascular endothelial growth factor and IL-Asthma prior sinus surgery and blood eosinophilia were the top predictors for postsurgical uncontrolled disease For subgroup analysis sex in group asthma in group tissue IL-and immunoglobulin E in group and prior sinus surgery in group were the strongest predictors of uncontrolled disease respectively Conclusion Different blood and tissue eosinophilia revealed distinct tissue inflammatory patterns in CRSwNP patients © 2020 ARS-AAOA, LLC.

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“…Moreover, during host defense, eosinophils produce a variety of chemical mediators that can induce detrimental effects on the host. Elevated blood eosinophil counts correlated with tissue eosinophilic inflammation and to the disease severity and the recurrence of CRS after sinus surgery [ 22 , 23 ]. Eosinophil counts in peripheral blood might be a biomarker for severe intractable CRS with type 2 inflammation.…”

Section: Introductionmentioning

confidence: 99%

Immunopathologic Role of Eosinophils in Eosinophilic Chronic Rhinosinusitis

Shin

Park

et al. 2022

IJMS

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Chronic rhinosinusitis (CRS) is a diverse chronic inflammatory disease of the sinonasal mucosa. CRS manifests itself in a variety of clinical and immunologic patterns. The histological hallmark of eosinophilic CRS (ECRS) is eosinophil infiltration. ECRS is associated with severe disease severity, increased comorbidity, and a higher recurrence rate, as well as thick mucus production. Eosinophils play an important role in these ECRS clinical characteristics. Eosinophils are multipotential effector cells that contribute to host defense against nonphagocytable pathogens, as well as allergic and nonallergic inflammatory diseases. Eosinophils interact with Staphylococcus aureus, Staphylococcal enterotoxin B, and fungi, all of which were found in the tissue of CRS patients. These interactions activate Th2 immune responses in the sinonasal mucosa and exacerbate local inflammation. Activated eosinophils were discovered not only in the tissue but also in the sinonasal cavity secretion. Eosinophil extracellular traps (EETs) are extracellular microbes trapping and killing structures found in the secretions of CRS patients with intact granule protein and filamentous chromatic structures. At the same time, EET has a negative effect by causing an epithelial barrier defect. Eosinophils also influence the local tissue microenvironment by exchanging signals with other immune cells and structural cells. As a result, eosinophils are multifaceted leukocytes that contribute to various physiologic and pathologic processes of the upper respiratory mucosal immune system. The goal of this review is to summarize recent research on the immunopathologic properties and immunologic role of eosinophils in CRS.

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Blood eosinophils may predict radiographic sinus opacification in patients with chronic rhinitis

Cited by 4 publications

References 31 publications

Peripheral blood eosinophil and classification of residual hematoma help predict the recurrence of chronic subdural hematoma after initial surgery

Peripheral blood eosinophil and classification of residual hematoma help predict the recurrence of chronic subdural hematoma after initial surgery

Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia

Immunopathologic Role of Eosinophils in Eosinophilic Chronic Rhinosinusitis

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