Blood equivalent phantom vs whole human blood, a comparative study

Karpienko, Katarzyna; Gnyba, Marcin; Milewska, D.; Wróbel, Maciej S.; Jędrzejewska‐Szczerska, Małgorzata

doi:10.1142/s1793545816500127

Cited by 15 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, optical techniques are receiving rising interest as non-invasive tools for medical diagnostics. Detecting clinical-level changes in the parameters of bodily fluids, such as intracranial cerebrospinal fluid pressure [1], blood glucose levels [2,3], microvasculature blood flow rates [4] as well as the parameters of the blood itself [5][6][7] are of great importance and are extensively studied. Optical phantoms are used mainly for calibration and development of these optical measurement and imaging systems [8,9].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

Wróbel

Попов

Bykov

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

We present an alternative to the conventional approach, phantoms without scattering nanoparticles, where scattering is achieved by the material itself: spherical cavities trapped in a silicone matrix. We describe the properties and fabrication of novel optical phantoms based on a silicone elastomer polydimethylsiloxane (PDMS) and glycerol mixture. Optical properties (absorption coefficient µa , reduced scattering coefficient µs' , and anisotropy factor g) of the fabricated phantoms were retrieved from spectrophotometric measurements (in the 400-1100 nm wavelength range) using the inverse adding-doubling method. The internal structure of the phantoms was studied under a scanning electron microscope, and the chemical composition was assessed by Raman spectroscopy. Composition of the phantom material is reported along with the full characterization of the produced phantoms and ways to control their parameters.

show abstract

Section: Introductionmentioning

confidence: 99%

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

Wróbel

Попов

Bykov

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Therefore, we utilized a solid imaging target instead of the actual blood vasculature. According to the literature, the absorbance of polyactic material (with a normalized absorbance ~25% [ 69 ]) at the imaging wavelength of 690 nm is close to the absorbance of blood (with the normalized absorbance of ~20% [ 70 ]).…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Manwar

Kratkiewicz

Avanaki

2020

Sensors

View full text Add to dashboard Cite

Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light illumination and ultrasound propagation paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the illumination path and acoustic propagation path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.

show abstract

“…The obtained solution was divided into separate layers and the saline was removed. The procedure of washing red blood cells was performed twice (this procedure was described in detail elsewhere ). The final step was the breakdown of the erythrocytes with the use of TritonX‐100 Biochemica (PanReac AppliChem, ITW Reagents, Barcelona, Spain) to obtain hemoglobin in saline solution.…”

Section: Methodsmentioning

confidence: 99%

Label‐free optical detection of cyclosporine in biological fluids

Marzejon

Kosowska

Majchrowicz

et al. 2018

Journal of Biophotonics

View full text Add to dashboard Cite

In this paper, a spectroscopic method for determination of cyclosporine concentrations in biological fluids is presented. Blood plasma and hemoglobin solutions are chosen for the experiment. For various cyclosporine concentrations in blood plasma and hemoglobin, absorbance measurements in spectra range from 600 to 1100 nm are performed. The measurement results are analyzed by the use of a dedicated algorithm. The obtained data are characterized by a high coefficient of correlation R 2 , which is equal to 0.9461 and 0.9808 for blood plasma and hemoglobin, respectively. The proposed method enables the selective detection of cyclosporine level and could be applied in medicine and laboratory diagnostics. The obtained result can be the base to build the point-of-care CsA level detection optical sensor.

show abstract

Blood equivalent phantom vs whole human blood, a comparative study

Cited by 15 publications

References 48 publications

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Label‐free optical detection of cyclosporine in biological fluids

Contact Info

Product

Resources

About