Blood flow and damage by the roller pumps during cardiopulmonary bypass

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

“…In studies of the continuous pumping of blood cells for cardiopulmonary bypass operations, peristaltic pumping has been cited as a cause of lysis and cumulative sub-lethal damage generally attributed to compression of the tubing as the pump rollers rotate (Sutera, 1977;Watanabe et al, 2006). Using computational fluid dynamics to model a two roller pump, Mulholland et al (2005) Overall, from the literature, it can be concluded that sub-lethal damage to the CHO cells cultivated in this work due to their passage through a peristaltic pump is not an unrealistic explanation for the deterioration in process performance found under those conditions. There is also evidence in the literature over many years that fluid dynamic stresses alone should not damage proteins.…”

Pressure pulsation in roller pumps: A validated lumped parameter model

“…Tube occlusion was manually set according to a clinically established protocol (London Independent Clinical Protocols, 1994) reported in [15], and the degree of occlusion thus obtained was referred to as optimal. By looking at Fig.…”

“…The control experiment (case (a) in Table 2) was characterized by a roller speed equal to 54 rpm, an optimal degree of occlusion [15] and with no clamp on the inlet/outlet tubes. A second experiment (case (b)) was performed with the same control conditions, with the exception of the pump speed which was set to 108 rpm.…”

“…In particular, they were aimed at simulating patient hemodynamics during artificial perfusion [9,10], developing automated perfusion strategies [11][12][13], and optimizing the design of CPB circuits [14], but none of them was focused on the pumping element, usually modelled as a pure flow generator. A two-dimensional CFD model of a roller pump is reported in [15]. This study gave useful information about roller pump fluid dynamics; however the model did not focus on the uncontrolled pulsatility dynamics.…”

Os perfusionistas Brasileiros e o ajuste do rolete arterial: comparação entre a calibração estática e dinâmica

“…However, studies comparing the two pump models have shown benefits of using centrifugal pumps and are not conclusive [14][15][16]. As a result, many perfusionists continue to use roller pumps as arterial pumps, which are simple to use and have low cost [17].…”