Blood Flow and Gastrointestinal Function

Bynum, T. E.; Jacobson, Eugene D.

doi:10.1016/s0016-5085(71)80155-5

Cited by 28 publications

(5 citation statements)

References 37 publications

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“…For a given drug formulation the rate of absorption from the gastro-intestinal tract in fasting individuals could be modified by alterations in mucosal blood flow, digestive secretions and alimentary motility (Smythe, 1964). The impairment of drug absorption during a migraine attack could be related to changes in all these factors but there is at present no technique suitable for measurement of mucosal blood flow in man (Bynum & Jacobson, 1971) and no techniques have been described for the measurement of digestive secretions during drug absorption studies. However, radiological observations during migraine have demonstrated reduced gastric motility (Kaufman & Levine, 1936;Kreel, 1973) and metoclopramide is known to promote gastro-intestinal motility and gastric emptying in man (Bhaduri & Bradley, 1969;Connell & George, 1969;Howarth, Cockel & Hawkins, 1967;Johnson, 1973;Howard & Sharp, 1973;Nimmo et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

Volans¹

1975

Brit J Clinical Pharma

134

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1 The absorption of effervescent aspirin was studied in two groups of patients during attacks of migraine. The first group received effervescent aspirin alone whilst the second group received intramuscular metoclopramide before effervescent aspirin. 2 After effervescent aspirin alone there was significant impairment in the rate of aspirin absorption during migraine attacks compared with the rate of aspirin absorption in normal volunteers and in the same patients when headache‐free. 3 When metoclopramide was given before effervescent aspirin the rate of aspirin absorption during migraine attacks was not significantly different from that obtained in normal volunteers given effervescent aspirin alone or from that obtained in the patients themselves when given both metoclopramide and effervescent aspirin when headache‐free. 4 It is concluded that the impairment of absorption of effervescent aspirin during migraine attacks is related to impaired gastro‐intestinal motility with delayed gastric emptying and that this impaired motility can be overcome by parenteral metoclopramide.

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Section: Discussionmentioning

confidence: 99%

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

Volans¹

1975

Brit J Clinical Pharma

134

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“…Although particle size and other factors in the formulation of a drug may have a profound effect upon its absorption and bio-availability (Wagner, 1964;Levy & Gumtow, 1963), these factors are not relevant in the present experiment where the drug was administered in solution. Measurement of mucosal blood flow is not yet possible in man (Bynum & Jacobson, 1971) and there are no published studies of digestive secretions during drug absorption studies. The intestinal contents can be controlled by dietary measures and in so far as alimentary motility is affected by exercise (Holdstock, Misiewicz, Smith & Rowlands, 1970) this factor can be standardized.…”

Section: Discussionmentioning

confidence: 99%

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

VOLANS

1974

Brit J Clinical Pharma

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The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non‐fasting states. Moderate activity resulted in no significant changes in absorption compared with that at rest. In non‐fasting subjects the absorption was reduced but this reduction was attenuated with time until after 60 min the plasma levels were similar. There was no interaction between the resting/non‐resting and fasting/non‐fasting absorption.

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“…Bell and Battersby [4] using the clearance of the radioactive gas SaKrypton from the canine gastric mucosa found that truncal vagotomy produced a significant immediate decrease in GMBF, but Bell and Shelley [18] observed that this postvagotomy reduction was not maintained for a long time. Bynnum and Jacobson [19] found that truncal vagotomy reduced the increased GMBF and GA stimulated by histamine, and observed a significant correlation between these parameters although other investigators [3,20,21] did not confirm a direct relationship between them. Nakamura et al [22,23], using the aminopyrine clearance technique, found that truncal and selective vagotomy caused a reduction of GMBF and observed that the effect continued for 3 months postoperatively.…”

Section: Discussionmentioning

confidence: 91%

“…Table 3 shows that GMBF in the resting state does not suffer significant change 2 months after HSV, since the mean values do not differ significantly. Others have found a decrease of GMBF even during the resting state after truncal [19] and/or selective vagotomy [23]. HSV produced a reduction of betazole-stimulated GMBF, GS, and GA and preserved postoperatively the GMBF almost up to the levels of the resting state.…”

Section: Discussionmentioning

confidence: 95%

The effect of highly selective vagotomy on canine gastric mucosal blood flow

et al. 1981

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Gastric mucosal blood flow (GMBF) was studied before and after highly selective vagotomy (HSV) by the pertechnate clearance technique. The studies were done on 24 mongrel dogs (Group A) under general anesthesia. Betazole was used to increase GMBF and gastric secretion (GS), and phenolred solution was used to correct the volume of GS collected by continuous aspiration. In all animals the measurements were done under resting, betazole-stimulated conditions, and then immediately after HSV. In 12 of the 24 dogs (Group B) the same measurements were done again 2 months later. The findings of the study indicate that betazole-stimulated GMBF was significantly decreased immediately after HSV (p < 0.001). Betazole stimulation resulted in a 6-fold increase of GMBF from the resting state before HSV, but only a 2-fold increase 2 months after HSV. GS showed a significant decrease right after HSV without a significant difference (p < 0.30) from the resting state. Two months postoperatively GS showed no significant difference from the resting state after betazole stimulation. There was a linear correlation between GMBF and GS before and after HSV but the correlation coefficients were not statistically significant.

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Blood Flow and Gastrointestinal Function

Cited by 28 publications

References 37 publications

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

The effect of highly selective vagotomy on canine gastric mucosal blood flow

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