Blood flow characteristics of diabetic patients with complications detected by optical measurement

An, Yun‐Kyu; Kang, Yang Jun; Lee, Jungsul; Ahn, Cheol Min; Kwon, Kihwan; Choi, Chulhee

doi:10.1186/s12938-018-0457-9

Cited by 17 publications

(9 citation statements)

References 59 publications

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“…Macro-and microcirculatory disorders manifest because of insufficient blood flow velocity and volume in the early stages of diabetes. However, blood flow velocity is faster in patients with advanced disease and microvascular complications [14][15][16], including vascular tone disruption occur. Peripheral limb blood flow decreases dramatically due to vessel damage caused by hyperglycemia [17] and those patients are vulnerable to vascular endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap

et al. 2022

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The instep flap and medialis pedis flap are both originate based on the medial plantar artery. The medialis pedis flap is based from the deep branch and the instep flap is based from the superficial branch. To increase the axial rotation, it is acceptable to ligate the lateral plantar artery. However, this can partially affect the blood supply of the plantar metatarsal arch. We restored the blood flow with a vein graft between the posterior tibial artery and the ligated stump. From 2012 to 2020, 12 cases of heel reconstruction, including seven instep flaps and five medialis pedis flaps, were performed with ligation of the lateral plantar artery. The stump of the lateral plantar artery was restored with a vein graft and between the posterior tibial artery and the ligated stump. Patients were followed for 18 months. Long-term results showed the vascular restoration of the lateral plantar artery remained patent demonstrated by doppler ultrasonography. Restoring blood flow to the lateral plantar artery maintains good blood supply to the toes. If the patient in the future develops a chronic degenerative disease, with microvascular complications, bypass surgery can still be performed because of the patency of both branches.

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Section: Discussionmentioning

confidence: 99%

Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap

et al. 2022

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“…Apart from the assessment of stored blood, we envision our proposed D50 metric to be used clinically to complement the existing measure of P50 in disease diagnosis, monitoring, or even intervention 1 . This may be especially pertinent in diseases associated with altered hemoglobin (such as sickle cell anemia 68 and beta thalassemia 69 ) or impaired perfusion (such as diabetic microangiopathies 70 and neurodegeneration 71 ). It is of note that our proposed D50 metric, similar to the conventional P50, does not consider the effects of RBC perfusion on the overarching tissue oxygenation efficacy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform

Chng

Namgung

et al. 2021

Commun Biol

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Red blood cells (RBCs) capability to deliver oxygen (O2) has been routinely measured by P50. Although this defines the ability of RBCs to carry O2 under equilibrium states, it cannot determine the efficacy of O2 delivery in dynamic blood flow. Here, we developed a microfluidic analytical platform (MAP) that isolates single RBCs for assessing transient changes in their O2 release rate. We found that in vivo (biological) and in vitro (blood storage) aging of RBC could lead to an increase in the O2 release rate, despite a decrease in P50. Rejuvenation of stored RBCs (Day 42), though increased the P50, failed to restore the O2 release rate to basal level (Day 0). The temporal dimension provided at the single-cell level by MAP could shed new insights into the dynamics of O2 delivery in both physiological and pathological conditions.

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“…Earlier studies have reported contradictory results on the in- and outflow patterns between patients with and without microvascular disease. 19,20 To provide cut-off values to guide treatment strategies, these differences in patient characteristics have to be incorporated.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared fluorescence imaging with indocyanine green for quantification of changes in tissue perfusion following revascularization

et al. 2021

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Objectives Current diagnostic modalities for patients with peripheral artery disease (PAD) mainly focus on the macrovascular level. For assessment of tissue perfusion, near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) seems promising. In this prospective cohort study, ICG NIR fluorescence imaging was performed pre- and post-revascularization to assess changes in foot perfusion. Methods ICG NIR fluorescence imaging was performed in 36 patients with PAD pre- and post-intervention. After intravenous bolus injection of 0.1 mg/kg ICG, the camera registered the NIR fluorescence intensity over time on the dorsum of the feet for 15 min using the Quest Spectrum Platform®. Time-intensity curves were plotted for three regions of interest (ROI): (1) the dorsum of the foot, (2) the forefoot, and (3) the hallux. Time-intensity curves were normalized for maximum fluorescence intensity. Extracted parameters were the maximum slope, area under the curve (AUC) for the ingress, and the AUC for the egress. The non-treated contralateral leg was used as a control group. Results Successful revascularization was performed in 32 patients. There was a significant increase for the maximum slope and AUC egress in all three ROIs. The most significant difference was seen for the maximum slope in ROI 3 (3.7%/s to 6.6%/s, p < 0.001). In the control group, no significant differences were seen for the maximum slope and AUC egress in all ROIs. Conclusions This study shows the potential of ICG NIR fluorescence imaging in assessing the effect of revascularization procedures on foot perfusion. Future studies should focus on the use of this technique in predicting favorable outcome of revascularization procedures.

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Blood flow characteristics of diabetic patients with complications detected by optical measurement

Cited by 17 publications

References 59 publications

Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap

Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap

Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform

Near-infrared fluorescence imaging with indocyanine green for quantification of changes in tissue perfusion following revascularization

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