Blood Flow Modeling in Carotid Arteries with Computational Fluid Dynamics and MR Imaging

Cebral, Juan R.; Yim, Peter J.; Löhner, Rainald; Soto, Orlando; Choyke, Peter L.

doi:10.1016/s1076-6332(03)80562-7

Cited by 130 publications

(103 citation statements)

References 22 publications

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“…in [2,3,4,5]) have been performed to study the WSS induced by blood flow and its relationship with aneurysm genesis. The problem with the CFD approach is that a huge computational cost is required for full 3D analysis of a large vasculature.…”

Section: Discussionmentioning

confidence: 99%

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A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

Sands

Schmid

et al. 2009

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009

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Abstract. In this paper we present a hybrid 1D/3D approach to haemodynamics modelling in a patient-specific cerebral vasculature and aneurysm. The geometric model is constructed from a 3D CTA image. A reduced form of the governing equations for blood flow is coupled with an empirical wall equation and applied to the arterial tree. The equation system is solved using a MacCormack finite difference scheme and the results are used as the boundary conditions for a 3D flow solver. The computed wall shear stress (WSS) agrees with published data.

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Section: Discussionmentioning

confidence: 99%

“…in [2,3,4,5]. The techniques used include non-invasive in vivo MR imaging [3], in vitro phantom experiments [4], and three-dimensional (3D) computational fluid dynamics (CFD) modelling [2], or a combination of these techniques [5].…”

Section: Introductionmentioning

confidence: 99%

A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

Sands

Schmid

et al. 2009

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009

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“…In large arteries, these corpuscles have dimensions much smaller than the diameter of the vessel and blood can be considered a homogeneous and incompressible fluid. Furthermore, it can be assumed to behave as a Newtonian fluid at high shear stress [1,16,18,19,20,21] . Continuity and momentum equations of Newtonian fluid with negligible body forces are described as Eq.…”

Section: Mathematical Representationmentioning

confidence: 99%

“…They also used implicit coupling methods to simulate 3D aortic valve motion to the increase accuracy and stability of the algorithm [15] . Cebral et al [16] simulated pulsatile flow of a real carotid artery obtained from MR images using an independent ring model for the elastic wall of the artery. They concluded that in rigid models, the regions with low shear stress (<10 dyn/cm 2 ) were smaller compare to those in elastic models.…”

Section: Introductionmentioning

confidence: 99%

Flow Characteristics in Elastic Arteries Using a Fluid-Structure Interaction Model

Oscuii¹,

Tafazzoli-Shadpour²,

Ghalichi³

2007

American J. of Applied Sciences

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Abstract:In this study the interaction of blood flow with arterial wall has been investigated using FSI (Fluid-Structure Interaction) modeling. Computer simulation of pulsatile blood flow was carried out on the basis of the time dependent axisymmetric Navier-Stokes equations for an incompressible Newtonian fluid flow. An elastic incompressible material with large deformation was considered for the arterial wall and momentum and continuity equations of elastodynamics have been solved. The specified boundary conditions for the Navier-Stokes equations were the pulsatile pressure waveforms of the brachial artery at inflow and outflow to the given pulse wave form of a cardiac cycle. Fluid and solid equations were solved with the ALE-based loose coupling method for FSI problems. Resultant flow, wall displacement, wall shear stress and wall circumferential strain waves, and their phase differences were determined. Stiffening of the arterial wall resulted in a significant decrease in the mean values of flow and wall shear stress and altered waveforms. A tenfold increase in wall stiffness caused 33% drop in flow and negative values of shear stress in 21% of the pressure pulse. For elastic moduli corresponding to wall displacements less than 1% the blood flow and wall shear stress were not sensitive to wall stiffness. Stress phase angle was altered by stiffening of the arterial wall. It was concluded that FSI modeling with pressure boundary conditions provides a proper evaluation of hemodynamic parameters that may determine endothelial injury.

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“…Other important factors for the rupture are the sudden increase of the arterial pressure and the increase of the intracranial volume. The studies of Hassan and Cebral focused in particular on the above mentioned problem (5,6,10). It was discovered that the geometric -morphometric parameters have a great significance in the hemodynamics of the intracranial blood vessels and aneurysms, as well as their rupture.…”

Section: Introductionmentioning

confidence: 99%

Predictible morfometric parameters for ruptrue of intracranial aneurysms – series of 142 operated aneurysms

Nikolić

Tasić²,

Bogosavljevic³

et al. 2011

Turkish Neurosurgery

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AIM: Intracranial aneurysm rupture is followed by high mortality and morbidity. In order to understand the aneurysm's natural course, it is necessary to recognize the predisposing factors for the rupture. ResULTs:The ratio between the width of the aneurysm neck and diameter of the carrying blood vessel -artery in ruptured aneurysms (OR) was 1.58±0.61, and in unruptured aneurysms 1.14±0.52 (p<0.01). Aspect ratio of ruptured aneurysm was 1.89 ± 0.59, and in unruptured 1:33 ± 0.17. The angle of inclination of ruptured aneurysms was 139.22 ± 21.53, while in unruptured aneurysms it was 101.73 ± 21.26. CoNCLUsIoN:Based on the results of our research, a predictive model of morphometric characteristics of the vessel bearing the aneurysm to rupture can be identified: an irregular shape of the aneurysm, AR> 1.6, OR> 1.5 and inclination angle >135 deg. soNUÇ: Araştırmamızın sonuçları temelinde rüptüre olacak anevrizmayı taşıyan damarın morfometrik özelliklerinin prediktif bir modeli tanımlanabilir: Anevrizmada düzensiz şekil, aspekt oranı >1,6, OR >1,5 ve inklinasyon açısı >135 derece.

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Blood Flow Modeling in Carotid Arteries with Computational Fluid Dynamics and MR Imaging

Cited by 130 publications

References 22 publications

A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

Flow Characteristics in Elastic Arteries Using a Fluid-Structure Interaction Model

Predictible morfometric parameters for ruptrue of intracranial aneurysms – series of 142 operated aneurysms

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