Blood-flow Velocities of the Extraocular Vessels in Patients With High-tension and Normal-tension Primary Open-angle Glaucoma

Kaiser, Hedwig J.; Schoetzau, Andreas; Stümpfig, Daniela; Flammer, Josef

doi:10.1016/s0002-9394(14)70127-8

Cited by 211 publications

(163 citation statements)

References 29 publications

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“…15 Although secondary reduction of ocular blood flow can be observed in glaucoma, there is a component of ocular blood flow reduction that is independent of optic nerve damage and intraocular pressure. 16,17 In addition, upregulation of the hypoxia-inducible factor 1-␣ was observed in the optic nerve head of patients with glaucoma. 18 It was also shown that the reduced blood flow was not limited to the eye.…”

Section: Ho Et Al Open-angle Glaucoma and Strokementioning

confidence: 99%

Open-Angle Glaucoma and the Risk of Stroke Development

Lin

2009

Stroke

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Background and Purpose-Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. Methods-Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (nϭ4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, nϭ20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. Results-Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. Conclusions-Patients

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Section: Ho Et Al Open-angle Glaucoma and Strokementioning

confidence: 99%

Open-Angle Glaucoma and the Risk of Stroke Development

Lin

2009

Stroke

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“…As various ocular [1][2][3][4][5][6][7][8][9] and systemic 9-20 vascular risk factors have been linked to the occurrence and progression of glaucomatous optic neuropathy, it would follow that they should be addressed by specific therapy. Despite this knowledge, however, the principal treatment objective remains reduction of intraocular pressure (IOP) using the large therapeutic arsenal available on the market.…”

Section: Introductionmentioning

confidence: 99%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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Purpose To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. Methods Twenty-two newly diagnosed and previously untreated POAG patients (mean age7SD: 68.38711.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. Results Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (Po0.0001) and increase in MOPP (Po0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P ¼ 0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P ¼ 0.0170; P ¼ 0.0260, and P ¼ 0.0170; P ¼ 0.0240 respectively).Conclusion Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.

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“…techniques have pointed up both in high myopia (HM) and in chronic simple glaucoma (CSG) significant alterations in certain haemorrheologic parameters (Kaiser et al 1997;Montanari et a l. 1995;Galassi et al 1996). This study investigates by means of the EcoColorDoppler some aspects of the ocular haemodynamics in patients with HM and CSG in order to assess any optic nerve head microcirculation variations in either of the two pathologies.…”

Section: Discussionmentioning

confidence: 99%