Blood-Gas Transfer of O2 and CO2 in the Lungs: New Models Measurements and Conclusions

Mochizuki, Masaji

doi:10.1007/978-1-4684-8181-5_66

Cited by 1 publication

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“…Although this has led to the development of new drugs and “sterilizing” vaccines, this idea has not been well contrasted with the usual oxygen levels at which subcellular structures work (Mochizuki, 1990). The conclusion is that, like many other intracellular pathogens, M. tuberculosis always lives under hypoxic conditions, either when inside an isolated cell or when in a granuloma, whereas the high aerobiosis present in laboratory flasks is completely artificial.…”

Section: An Overview Of Tb Research a Tendentious Focus On The Bacillusmentioning

confidence: 99%

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies

Vilaplana

Cardona

2014

Front. Microbiol.

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This short review explores the large gap between clinical issues and basic science, and suggests why tuberculosis research should focus on redirect the immune system and not only on eradicating Mycobacterium tuberculosis bacillus. Along the manuscript, several concepts involved in human tuberculosis are explored in order to understand the big picture, including infection and disease dynamics, animal modeling, liquefaction, inflammation and immunomodulation. Scientists should take into account all these factors in order to answer questions with clinical relevance. Moreover, the inclusion of the concept of a strong inflammatory response being required in order to develop cavitary tuberculosis disease opens a new field for developing new therapeutic and prophylactic tools in which destruction of the bacilli may not necessarily be the final goal.

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Section: An Overview Of Tb Research a Tendentious Focus On The Bacillusmentioning

confidence: 99%

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies

Vilaplana

Cardona

2014

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

Blood-Gas Transfer of O2 and CO2 in the Lungs: New Models Measurements and Conclusions

Cited by 1 publication

References 5 publications

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies

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