Blood glucose levels in a population of healthy, breast fed, term infants of appropriate size for gestational age

Hoseth, Eva

doi:10.1136/fn.83.2.f117

Cited by 125 publications

(99 citation statements)

References 9 publications

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“…This was also noted by Hoseth et al, Hawdon et al and Diwakar et al in their studies. 3,4,14 The ability of neonatal brain to use alternative fuels like ketone bodies may ensure the infant to be symptom free. This was extensively studied by Hawdon et al but he also remarked that metabolic substrates other than glucose may play important role only after 48-72 hours of life, until that glucose continues to be the major source of energy supply to brain.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of asymptomatic hypoglycemia in Term appropriate for gestational age babies was found to vary between 12-14%. 3,4 Symptomatic hypoglycemia presents with non-specific features like jitteriness, apathy, episodes of cyanosis, convulsions, apneic spells, weak or high pitch cry, limpness (or) lethargy, difficulty in feeding and hypothermia. 5 Both symptomatic and asymptomatic hypoglycemia were found to be associated with adverse long term neurodevelopmental outcome as shown by lower head circumference and developmental scores.…”

Section: Introductionmentioning

confidence: 99%

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The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

Thirumalaikumarasamy

Ramalingam

Moorthi

et al. 2017

Int J Contemp Pediatr

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Background: Neonatal hypoglycemia is a common metabolic problem especially in cases like prematurity, sepsis and small gestational age. Episodes of asymptomatic hypoglycemia may occur due to many risk factors. The present study aimed to evaluate the incidence of asymptomatic hypoglycemia in term new born babies weighing more than 2 kg, to study the plasma sugar level at various time points during first 48 hours of life and to study the effect of maternal factors like parity, mode of delivery, glucose infusion during labour, and time since last feed on plasma sugar level.Methods: A hospital based longitudinal study was conducted over a period of one year from April 2005 to March 2006 in Kilpauk Medical College Hospital, Chennai. 400 babies born of consecutive deliveries were included in the study. Their plasma glucose levels were assessed in cord blood, 3 hr, 12 hr and 36 hr of life. Plasma glucose levels were analysed with regards to distribution, variables like parity, mode of delivery, dextrose infusion during labour and time since last feed. The plasma glucose levels were statistically analysed by paired student ‘t’ test, multiple analysis of variance (ANOVA), chi- square test using SPSS (version 7.5) statistical package.Results: The overall incidence of hypoglycemia was seen in 20% of the neonate’s in which 29.7% in small gestational age (SGA) and 16.7% in appropriate gestational age (AGA) babies. A significant (p <0.01) association between hypoglycemia and birth weight was observed. The association between hypoglycemia with parity, mode of delivery, sex of the baby and glucose infusion received by the mother was studied, but no significant association was found. A significant difference in plasma glucose based on birth weight at 3rd hour, 12th hour and 36th hour was observed (p <0.05). None of the infants showed any clinical signs of hypoglycemia.Conclusions: The incidence of hypoglycemia was noted in 20% of the neonates. Low birth weight was considered as risk factor. A significant association was also observed between plasma glucose, mode of delivery and time since last fed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

Thirumalaikumarasamy

Ramalingam

Moorthi

et al. 2017

Int J Contemp Pediatr

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“…13,17 It is postulated that breastfed infants tolerate lower plasma glucose concentrations without any clinical manifestations or sequelae of NH because of the increased ketone concentrations. 8,[12][13][14] …”

Section: Which Infants To Screenmentioning

confidence: 99%

“…[6][7][8] Most neonates compensate for "physiologic" hypoglycemia by producing alternative fuels including ketone bodies, which are released from fat.…”

Section: Introductionmentioning

confidence: 99%

Postnatal Glucose Homeostasis in Late-Preterm and Term Infants

Adamkin¹

2011

Pediatrics

614

278

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This report provides a practical guide and algorithm for the screening and subsequent management of neonatal hypoglycemia. Current evidence does not support a specific concentration of glucose that can discriminate normal from abnormal or can potentially result in acute or chronic irreversible neurologic damage. Early identification of the at-risk infant and institution of prophylactic measures to prevent neonatal hypoglycemia are recommended as a pragmatic approach despite the absence of a consistent definition of hypoglycemia in the literature.

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“…2 Glucose is a very important substrate of metabolism especially in the brain. 3 Hypoglycemia is defined as a blood glucose less than 40 mg/dl. 4 Many different neonatal groups are at a risk of developing low blood glucose concentration for example pre-term baby, large for gestational age, infant of diabetic mother, intrauterine growth restriction (IUGR), sepsis, shock, asphyxia, hypothermia, respiratory distress syndrome (RDS).…”

Section: Introductionmentioning

confidence: 99%