Blood Glucose Levels in Elderly Subjects with Type 2 Diabetes During COVID-19 Outbreak: A Retrospective Study in a Single Center

Xue, Ting; Li, Qian-wen; Zhang, Qiongyao; Lin, Wei; Weng, Junping; Li, Li; Chen, Gang

doi:10.2139/ssrn.3566198

Cited by 24 publications

(16 citation statements)

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“…A recent study from China during the COVID-19 pandemic has shown that elderly subjects with type 2 diabetes mellitus experienced worsening of glycemic control manifesting as higher fasting blood glucose [5]. The impact of social distancing, quarantine and lockdown on lifestyles would have probably led to worsening of glucose control.…”

Section: Challenges To Diabetes Self-care Amid the Covid-19 Pandemicmentioning

confidence: 99%

Diabetes self-management amid COVID-19 pandemic

Banerjee

Chakraborty

Pal

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

205

204

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Background and aims: COVID-19 pandemic has challenged the physician-centered approach of diabetes care in India that is primarily based on routine clinic visits. We aim to review the various aspects of patient-centered care via diabetes self-management education based on available literature. Methods: This is a narrative review using Pubmed, EMBASE and Google Scholar search till March 29, 2020. Search terms were "COVID-19", "diabetes self-care", "diabetes self-management education", "DSME", "diabetes self-management in India", "diabetes self-care in India" and "DSME in India". Results: We have discussed an educational plan on diabetes self-management that can be adopted for people with diabetes mellitus in our country amid the ongoing pandemic. We have also identified the barriers to diabetes self-management in the current scenario and suggested possible solutions to overcome those. Conclusions: We have reemphasized the need for a simultaneous patient-centered approach in routine diabetes care that has to be coordinated by a multidisciplinary team amid the ongoing COVID-19 pandemic.

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Section: Challenges To Diabetes Self-care Amid the Covid-19 Pandemicmentioning

confidence: 99%

Diabetes self-management amid COVID-19 pandemic

Banerjee

Chakraborty

Pal

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

205

204

View full text Add to dashboard Cite

show abstract

“…However, widespread nationwide lockdowns would curtail their routine in-clinic visits, limit their physical activity, alter their food habits and adversely affect their psychological health; all these would ultimately lead to poor glycemic control [36]. Infact, a recent study from China had shown that elderly subjects with type 2 diabetes mellitus had higher fasting blood glucose during the COVID-19 pandemic [37]. Teleconsultations with registered medical practitioners would help people with DM circumvent a lot of problems imposed by lockdowns [38].…”

Section: Management Of Diabetes Mellitus Amid Covid-19 Pandemicmentioning

confidence: 99%

COVID-19 and diabetes mellitus: An unholy interaction of two pandemics

Pal

Bhadada

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

241

193

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Background and aims: Diabetes mellitus is associated with poor prognosis in patients with COVID-19. On the other hand, COVID-19 contributes to worsening of dysglycemia in people with diabetes mellitus over and above that contributed by stress hyperglycemia. Herein, we have reviewed the two-way interactions between COVID-19 and diabetes mellitus. Methods: We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till April 25, 2020, with the following keywords: "COVID-19", "SARS-CoV-2", "diabetes", "diabetes mellitus", "SARS", "infection" and "management of diabetes mellitus" with interposition of the Boolean operator "AND". Results: Compromised innate immunity, pro-inflammatory cytokine milieu, reduced expression of ACE2 and use of renin-angiotensin-aldosterone system antagonists in people with diabetes mellitus contribute to poor prognosis in COVID-19. On the contrary, direct b-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of COVID-19 (like corticosteroids, lopinavir/ritonavir) can contribute to worsening of glucose control in people with diabetes mellitus. Conclusions: The two-way interaction between COVID-19 and diabetes mellitus sets up a vicious cycle wherein COVID-19 leads to worsening of dysglycemia and diabetes mellitus, in turn, exacerbates the severity of COVID-19. Thus, it is imperative that people with diabetes mellitus take all necessary precautions and ensure good glycemic control amid the ongoing pandemic.

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“…The association between Covid-19 and hyperglycemia in elderly patients with T2D ( 60 ) seems likely to reflect metabolic inflammation and exaggerated cytokine release. Strikingly, recent data suggest that SARS-CoV2 infection can lead to a deterioration in glycemic control, involving both profound insulin resistance (requiring as much as 50–100 U insulin/h) and impaired insulin secretion, together leading to diabetic ketoacidosis, DKA ( 61 , 62 ).…”

Section: Covid-19 and Diabetes: A Vicious Circle?mentioning

confidence: 99%

Covid-19 and Diabetes: A Complex Bidirectional Relationship

et al. 2020

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Covid-19 is a recently-emerged infectious disease caused by the novel severe acute respiratory syndrome coronavirus SARS-CoV2. SARS-CoV2 differs from previous coronavirus infections (SARS and MERS) due to its high infectivity (reproduction value, R 0 , typically 2–4) and pre- or asymptomatic transmission, properties that have contributed to the current global Covid-19 pandemic. Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. The reasons for these associations are still largely obscure. Evidence is also emerging that SARS-CoV2 infection exacerbates the underlying pathophysiology of hyperglycemia in people with diabetes. Here, we discuss potential mechanisms through which diabetes may affect the risk of more severe outcomes in Covid-19 and, additionally, how diabetic emergencies and longer term pathology may be aggravated by infection with the virus. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action.

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Blood Glucose Levels in Elderly Subjects with Type 2 Diabetes During COVID-19 Outbreak: A Retrospective Study in a Single Center

Cited by 24 publications

References 0 publications

Diabetes self-management amid COVID-19 pandemic

Diabetes self-management amid COVID-19 pandemic

COVID-19 and diabetes mellitus: An unholy interaction of two pandemics

Covid-19 and Diabetes: A Complex Bidirectional Relationship

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