Blood glucose may condition factor VII levels in diabetic and normal subjects

Ceriello, Antonio; Giugliano, Dario; Quatraro, A; Russo, P. Dello; Torella, Roberto

doi:10.1007/bf00265372

Cited by 88 publications

(54 citation statements)

References 12 publications

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“…In some studies the correlation between plasma triglyceride and VIIc was found to be genotype specific [9, 10, 15±17] suggesting an interaction between genetic and environmental influence. A positive correlation between fasting plasma glucose and factor VII level has also been reported [18], and VIIc levels are increased in patients with Type II diabetes mellitus especially in the presence of microalbuminuria or albuminuria [19]. In a study of 95 Caucasian Type II diabetic patients, the R/Q353 genotype was found to contribute to 12 % of the variance in VIIc levels.…”

mentioning

confidence: 79%

Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus

Lam

Bourke

et al. 1998

Diabetologia

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Diabetes mellitus is associated with a two to threefold increase in cardiovascular mortality [1]. The mechanism whereby diabetes increases cardiovascular risk is probably multifactorial. Recent studies suggest that this may in part be attributed to an increase in thrombotic tendency [2] including an increase in circulating level of factor VII, a key enzyme in the initiation of coagulation. A positive correlation between increased factor VII activity and cardiovascular mortality has been shown in the Northwick Park Heart Study [3]. A similar trend Diabetologia (1998) In both diabetic and control subjects the allele frequencies of the R (M1) and Q (M2) alleles were 0.96 and 0.04; the corresponding reported frequencies in Caucasians being 0.90 and 0.10: VIIc were 21 % lower in Chinese control subjects and Type I diabetic patients with R/Q, compared with R/R subjects (p < 0.001 and p < 0.05). The corresponding difference was 4 % for Type II diabetc patients (p = NS). Type II diabetic patients had higher mean VIIc levels than control subjects and Type I diabetic patients (p < 0.01); they were also older, and had higher serum creatinine and triglyceride (all p < 0.01). They also had higher VIIc levels than an age-matched older control group (p < 0.01; n = 182) in whom the genotype effect was clearly seen. On stepwise linear regression analysis, the significant independent determinants of VIIc were serum triglyceride (contributing 20 % and 25 % to variance in control subjects and diabetic patients), the R/Q353 genotype (contributing to 12 % of the variance in control subjects but only 1 % in diabetic patients), age and total cholesterol in all subjects, and in the diabetic patients female sex, urinary albumin excretion rate and serum creatinine. VIIc was higher in diabetic patients with macroangiopathy and retinopathy (both p < 0.0001). We conclude that compared with Caucasians, the Q allele frequency is significantly lower in these Chinese subjects. Plasma VIIc is determined by both genetic and environmental influences such that in Chinese Type II diabetic patients, the effect of environmental factors predominates, almost negating the influence of the R/Q353 genotype. High VIIc may contribute to the increased cardiovascular risk in Type II diabetic patients. [Diabetologia (1998) 41: 760±766]

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mentioning

confidence: 79%

Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus

Lam

Bourke

et al. 1998

Diabetologia

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“…35,36 Since diabetic patients have been reported to have an increased thrombotic tendency, 16 we investigated whether one of the two diets could adversely affect the risk for thrombosis while improving the risk for atherosclerosis. We measured thrombotic factors that have been reported to be abnormal in diabetes, like TPA, factor VII, fibrinogen, [37][38][39][40] and PAI, 20 and/or factors that have been reported to be affected by dietary manipulations, like factor VII 41 and PAI. 42 Prothrombin fragment F1.2 was measured as a parameter of the state of thrombotic activation.…”

Section: Discussionmentioning

confidence: 99%

Differences in the Metabolism of Postprandial Lipoproteins After a High-Monounsaturated-Fat Versus a High-Carbohydrate Diet in Patients With Type 1 Diabetes Mellitus

Georgopoulos

Bantle

Noutsou

et al. 1998

ATVB

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Abstract-There is little information comparing the effects of a high-monounsaturated (Mono)-fat versus a highcarbohydrate (CHO) diet in patients with type 1 diabetes mellitus. In the present study, the effects of these diets on a number of metabolic parameters were compared. Seventeen normolipidemic, nonobese patients with type 1 diabetes were provided with the diets for 4 weeks each in a randomized, crossover design. The percentages of Mono fat of the two diets were 25 Mono versus 9 CHO, with a corresponding total fat content of 40% versus 24% and a total CHO content of 45% versus 61%. At the end of each dietary period, parameters of glycemic control, coagulation factors, and fasting and postprandial lipoproteins were assessed. There were no differences in weight, glycemia, insulin dose, fasting lipid profile, or coagulation factors between the two diets. However, the metabolism of postprandial lipoproteins after a fat load differed; viz, after the Mono diet compared with the CHO diet, mean plasma triglyceride levels over 10 hours were higher (Pϭ.0025, by repeated-measures ANOVA). The levels of triglyceride (Pϭ.0045) and retinyl esters (Pϭ.0046) in chylomicrons (S f Ͼ400) and chylomicron remnants (S f 100 to 400) (Pϭ.0047 and Pϭ.043, respectively), and the total particle number (apolipoprotein B levels) in chylomicron remnants (Pϭ.001) and small, very low density lipoprotein (S f 20 to 100, Pϭ.016) were also higher. Our data suggest that in patients with type 1 diabetes, a CHO diet might be preferable to a Mono diet, since adherence to the former results in a lower number of circulating postprandial lipoprotein particles that are potentially atherogenic. (Arterioscler Thromb Vasc Biol. 1998;18:773-782.)

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“…It emerges that acute glycemic variations are matched with a series of alterations of coagulation that are likely to cause a thrombosis. This tendency is documented by studies demonstrating that when hyperglycemia is induced, a shortening of the fibrinogen half-life (41) and an increase in fibrinopeptide A (42,43), in fragments of prothrombin (44), in factor VII (45), and in platelet aggregation (46) can be found in both normal and diabetic subjects. These data indicate that during experimental hyperglycemia, the coagulation is activated.…”

Section: Postprandial Hyperglycemia and Diabetesmentioning

confidence: 91%

Postprandial Hyperglycemia and Diabetes Complications

2005

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Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial "hyperglycemic spikes" may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes. Diabetes 54:1-7, 2005

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Blood glucose may condition factor VII levels in diabetic and normal subjects

Cited by 88 publications

References 12 publications

Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus

Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus

Differences in the Metabolism of Postprandial Lipoproteins After a High-Monounsaturated-Fat Versus a High-Carbohydrate Diet in Patients With Type 1 Diabetes Mellitus

Postprandial Hyperglycemia and Diabetes Complications

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