Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

Kino, Saiko; Tanaka, Yuki; Matsuura, Yuji

doi:10.1117/1.jbo.19.5.057010

Cited by 16 publications

(7 citation statements)

References 21 publications

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“…In this work, we propose a method for measuring the absorbance of an object, using an attenuated total reflection (ATR) prism and hollow fibers [11], which can efficiently transmit mid-infrared radiation to the object [12]. Moreover, we report the results of the noninvasive measurement of blood glucose levels, obtained using this method [13,14]. Figure 1 shows the outline of the measurement system used in this study.…”

Section: Methodsmentioning

confidence: 99%

Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Kasahara

Kino

Soyama

et al. 2017

Biomed. Opt. Express

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101

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A method for performing noninvasive blood glucose measurements was developed. The method is based on mid-infrared absorption spectroscopy and uses only a few wavenumbers to measure blood glucose levels unconditionally. We found that the regression of blood glucose levels using only three wavenumbers, which were selected using a series cross-validation technique, realized accuracies comparable to those of cases in which a greater number of wavenumbers are used. In addition, we demonstrated the performance of this model through correlations among different types of data.

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Section: Methodsmentioning

confidence: 99%

Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Kasahara

Kino

Soyama

et al. 2017

Biomed. Opt. Express

Self Cite

101

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“…We previously proposed a measurement system based on infrared attenuated-total-reflection (ATR) spectroscopy, composed of a Fourier-transform infrared (FT-IR) spectrometer and flexible hollow optical fibers that transmit mid-infrared light. From the absorption spectra measured for human lips, we confirmed clear fingerprint spectra of glucose, and blood glucose levels were estimated with high accuracy by focusing on the glucose absorption peak originating from the pyranose structure of glucose [10] [11].…”

Section: Introductionmentioning

confidence: 97%

Accuracy Improvement of Blood Glucose Measurement System Using Quantum Cascade Lasers

Kõyama¹,

Kino²,

Matsuura³

2019

OPJ

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For non-invasive measurement of blood glucose levels, a measurement system based on mid-infrared, attenuated-total-reflection spectroscopy equipped with hollow optical fibers, a trapezoidal multi-reflection prism, and two fixedwavelength quantum cascade lasers emitting different wavelengths is proposed. From the absorption spectra of lip mucosa measured by Fouriertransform infrared spectrometry, two wavelengths, 1152 cm −1 for absorption by glucose and 1186 cm −1 for the background, were chosen. To reduce measurement errors, the power distribution on the prism surface was investigated, and it was found that some high-intensity spots appear on the prism surface due to the coherency of the laser beam. This inhomogeneous power distribution causes measurement errors for slight movements of the lip mucosa. To homogenize the intensity distribution on the prism, a lens to excite higher modes in the fiber was introduced, and the incident angle was changed to suppress interference due to back-reflected light. These improvements increased the measurement stability, and in-vivo experiments demonstrated that the measured optical absorption correlates well with blood glucose levels.

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“…Therefore, it is difficult to quantify the optical path length for biological samples that do not have a defined reflection plane. Conventionally, the method of attenuated total reflection (ATR) 15,16 has been used for measuring the mid-infrared absorbance of biological samples. This method can detect wavelengths in evanescent light reflecting from within 5 μm of the surface of the sample.…”

Section: Introductionmentioning

confidence: 99%

Parametric standing wave generation of a shallow reflection plane in a nonrigid sample for use in a noninvasive blood glucose monitor

et al. 2019

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When monitoring a moist sample using mid-infrared spectroscopy, its thickness must be <100 μm to avoid light absorption from the water. Therefore, we propose an ultrasonic-assisted mid-infrared spectroscopic imaging method that can generate a reflection plane at a depth of 100 μm from the surface of the sample by creating an ultrasonic standing wave. A frequency of 10 MHz is required to obtain an optical path length of 100 μm in biological samples. However, because biological samples generally have high compressibility, attenuation of ultrasonic waves at this frequency is significant. We use agar as a biological phantom and observe that a reflection plane is generated inside by ultrasonic standing waves using optical coherence tomography. It is found that when the sample is vibrated with an 800-kHz ultrasonic wave, a reflection plane is generated at a depth shallower than the theoretically predicted value. We believe that the reflection plane is generated by parametric standing waves, which are based on parametric effect. We detect the waveform distortion using an acoustic emission sensor and confirm the higher harmonics that generate the observed reflection plane using a fast Fourier transform.

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Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

Cited by 16 publications

References 21 publications

Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Accuracy Improvement of Blood Glucose Measurement System Using Quantum Cascade Lasers

Parametric standing wave generation of a shallow reflection plane in a nonrigid sample for use in a noninvasive blood glucose monitor

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