Blood Glucose Measurements by Photoacoustics

MacKenzie, H. A.; Ashton, Helen; Shen, Yaochun; Lindberg, John M.; Rae, Peter; Quart, K.M.; Spiers, Stephen

doi:10.1364/bosd.1998.btuc1

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…This technology has been tested in aqueous solution, in gelatine-based tissue simulations, whole blood and in vivo [47,48]. No interference was noted from NaCl, cholesterol or albumin.…”

Section: Photoacoustic Spectroscopymentioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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Glucose monitoring technology has been used in the management of diabetes for three decades. Traditional devices use enzymatic methods to measure glucose concentration and provide point sample information. More recently continuous glucose monitoring devices have become available providing more detailed data on glucose excursions. In future applications the continuous glucose sensor may become a critical component of the closed loop insulin delivery system and, as such, must be selective, rapid, predictable and acceptable for continuous patient use. Many potential sensing modalities are being pursued including optical and transdermal techniques. This review aims to summarize existing technology, the methods for assessing glucose sensing devices and provide an overview of emergent sensing modalities.

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“…This technology has been tested in aqueous solution, in gelatine-based tissue simulations, whole blood and in vivo [47,48]. No interference was noted from NaCl, cholesterol or albumin.…”

Section: Photoacoustic Spectroscopymentioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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“…Various optical glucose monitoring approaches have been reviewed in the literature. 7−9 Those based on the use of optical modalities include Raman spectroscopy, 10−14 optical coherence tomography (OCT), 15,16 photoacoustic spectroscopy, 17−19 optical polarimetry, 20−24 infrared spectroscopy, 25,26 and fluorescence spectroscopy. 27−31 …”

Section: Introductionmentioning

confidence: 99%

A Layer-by-Layer Approach To Retain a Fluorescent Glucose Sensing Assay within the Cavity of a Hydrogel Membrane

Locke¹,

Means²,

Dong³

et al. 2018

ACS Appl. Bio Mater.

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A continuous glucose monitoring device that resides fully in the subcutaneous tissue has the potential to greatly improve the management of diabetes. Toward this goal, we have developed a competitive binding glucose sensing assay based on fluorescently labeled PEGylated concanavalin-A (PEGylated-TRITC-ConA) and mannotetraose (APTS-MT). In the present work, we sought to contain this assay within the hollow central cavity of a cylindrical hydrogel membrane, permitting eventual subcutaneous implantation and optical probing through the skin. A “self-cleaning” hydrogel was utilized because of its ability to cyclically deswell/reswell in vivo, which is expected to reduce biofouling and therefore extend the sensor lifetime. Thus, we prepared a hollow, cylindrical hydrogel based on a thermoresponsive electrostatic double network design composed of N-isopropylacrylamide and 2-acrylamido-2-methylpropanesulfonic acid. Next, a layer-by-layer (LbL) coating was applied to the inner wall of the central cavity of the cylindrical membrane. It consisted of 5, 10, 15, 30, or 40 alternating bilayers of positively charged poly(diallyldimethylammonium chloride) and negatively charged poly(sodium 4-styrenesulfonate). With 30 bilayers, the leaching of the smaller-sized component of the assay (APTS-MT) from the membrane cavity was substantially reduced. Moreover, this LbL coating maintained glucose diffusion across the hydrogel membrane. In terms of sensor functionality, the assay housed in the hydrogel membrane cavity tracked changes in glucose concentration (0 to 600 mg/dL) with a mean absolute relative difference of ∼11%.

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“…The photoacoustic NIR measurement technique has also been used and promising results were recently published by MacKenzie et al 17 A further technique currently under investigation is fluorescence spectroscopy. Usually, the specimens studied are multicomponent systems, with individual components contributing many overlapping signals.…”

Section: Optical Glucose Sensingmentioning

confidence: 99%

Glucose, In Vivo Assay of

Heise

2000

Encyclopedia of Analytical Chemistry

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In vivo glucose sensing and regulation is necessary for patients with carbohydrate metabolism disorders, particularly those caused by diabetes mellitus. Self‐monitoring of blood glucose is part of the daily routine for such patients, and the measurement of capillary blood glucose, using different enzymatic assays in combination with photometric or electrochemical detection, still remains the standard method. Research activities concentrate on developing minimally invasive and noninvasive methodologies, the latter being based on spectroscopic techniques exploiting optical glucose specific characteristics, i.e. wavelength‐dependent absorptivities and refractive indices, mainly in the near‐infrared (NIR), or the rotation of linearly polarized radiation in the visible range. Owing to the complexity of the integrally probed tissue, and the presence of many interfering compounds, only multivariate spectroscopic measurement strategies, using several wavelengths, can be used for a noninvasive in vivo assay of glucose. Further complications arise from the heterogeneous distribution of glucose in the intravascular, interstitial and intracellular space and differences in their dynamics. In contrast to the established reference methodology which uses capillary blood, especially for the hypoglycemic concentration range, the imprecision observed so far within several experimental optical approaches is regarded as unacceptable for patient self‐monitoring. Further research is needed to establish an in vivo glucose assay for diabetic patients, or for direct monitoring in intensive care units and operating theatres, based on optical spectroscopy.

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Blood Glucose Measurements by Photoacoustics

Cited by 14 publications

References 10 publications

Glucose sensors: a review of current and emerging technology

Glucose sensors: a review of current and emerging technology

A Layer-by-Layer Approach To Retain a Fluorescent Glucose Sensing Assay within the Cavity of a Hydrogel Membrane

Glucose, In Vivo Assay of

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