Blood group O convalescent plasma donations have significantly lower levels of <scp>SARS‐CoV</scp>‐2 <scp>IgG</scp> antibodies compared to blood group A donations

Hayes, Chelsea; Rubenstein, Wesley; Gibb, David R.; Klapper, Ellen; Tanaka, J; Pepkowitz, Samuel H.

doi:10.1111/trf.16524

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…Our results do not confirm the previous reports that the ABO blood group type affects the anti‐SARS‐CoV‐2 antibody concentration in COVID‐19 convalescents 19–22 . In our cohort, we found no statistically significant differences between the SARS‐CoV‐2 antibody levels in different ABO‐types regardless of which serological method was used.…”

Section: Discussioncontrasting

confidence: 99%

“…[5][6][7][8][9][10] Therefore, it was logical that the following research would focus on the impact of ABO blood group type on the quantity of anti-SARS-CoV-2 antibodies produced in convalescents since the CCP represents a valuable resource for prevention and therapy. Since the resulting studies led to conflicting results, [16][17][18][19][20][21][22] we analyzed a larger cohort of 3187 COVID-19 convalescent plasma donors.…”

Section: Discussionmentioning

confidence: 99%

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ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors

et al. 2022

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Background The association of the ABO blood group with COVID‐19 disease has been confirmed by several studies, with the blood group A patients being more susceptible and prone to a more severe clinical course of the disease. Additionally, several authors also addressed the association of ABO‐types and the levels of anti‐SARS‐CoV‐2 antibodies in convalescents, mostly supporting a theory that the non‐O blood group convalescents present with higher levels of anti‐SARS‐CoV‐2 antibodies. Study Design and Methods Since previous findings were based on small convalescent cohorts, we quantified the anti‐SARS‐CoV‐2 antibody levels in a total of 3187 convalescent plasma donors with three commercial serological and one standard neutralizing antibody test. The majority of donors had undergone a mild form of the disease and the median time of sampling was 66 days after diagnosis. Results None of the antibody quantitation results showed any significant association with the ABO blood group types. The same result was evident in the subgroup of vaccinated individuals (n = 370) and the subgroups when stratified according to post‐COVID‐19 periods (0–60, 60–120, and 120–180 days). Conclusion In conclusion, we found no evidence to confirm that the ABO blood group types influence the level of SARS‐CoV‐2 antibody response in COVID‐19 convalescent plasma donors.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors

et al. 2022

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“…Approximately 10% of the Japanese population is estimated to have blood type AB [17], and a similar percentage of this blood type was observed in the present study. In accordance with our findings, previous studies have also reported that donors with blood type AB have higher antibody titers than those with blood type O [18,19] and that patients with COVID-19 have lower levels of ABO antibodies than uninfected individuals [20]. These findings indicate that blood type ABO may have some influence on the development of SARS-CoV-2 infection and antibody production.…”

Section: Discussionsupporting

confidence: 92%

Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan

Suzuki¹,

Asai²,

Ide³

et al. 2022

Journal of Infection and Chemotherapy

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The ability to predict which patients with a history of coronavirus disease (COVID-19) will exhibit a high antibody titer is necessary for more efficient screening of potential convalescent plasma donors. We aimed to identify factors associated with a high immunoglobulin G (IgG) titer in Japanese convalescent plasma donors after COVID-19. Methods: This cross-sectional study included volunteers undergoing screening for convalescent plasma donation after COVID-19. Serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-protein IgG antibodies were measured using a high-sensitivity chemiluminescence enzyme immunoassay. Results: IgG antibodies were measured in 581 patients, 534 of whom had full information of selected independent variables. Multiple linear regression analysis revealed that increasing age (1.037 [1,025, 1.048]), days from symptom onset to sampling (0.997 [0.995, 0.998]), fever (1.664 [1.226, 2.259]), systemic corticosteroid use during 3.601]), and blood type AB (1.478 [1.032, 2.117]) predict antibody titer. Conclusion: Older participants, those who experienced fever during infection, those treated with systemic corticosteroids during infection, those from whom samples were obtained earlier after symptom onset, and those with blood type AB are the best candidates for convalescent plasma donation. Therefore, these factors should be incorporated into the screening criteria for convalescent plasma donation after SARS-CoV-2 infection.

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“…In contrast, Hayes et al showed that blood Type O had significantly lower levels of anti-N IgG compared to blood type A [ 50 ]. The other two studies reported lower levels of nAbs, anti-S and anti-RBD Abs in persons with blood type O compared to subjects with blood Types AB and B [ 18 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Grujic

Bujandric

Budakov-Obradović

et al. 2021

IJERPH

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Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals (n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals (p = 0.034), older age groups (p < 0.001), existence of hypertension (p = 0.008), and severe COVID-19 (p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

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Blood group O convalescent plasma donations have significantly lower levels of SARS‐CoV‐2 IgG antibodies compared to blood group A donations

Cited by 15 publications

References 16 publications

ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors

ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors

Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

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