Blood group phenotype frequencies in blood donors from a tertiary care hospital in north India

Abstract

BackgroundKnowledge about the frequency of red blood cell-antigen phenotypes in a population can be helpful in the creation of a donor data bank for the preparation of indigenous cell panels and for providing antigen-negative compatible blood to patients with multiple alloantibodies.MethodsABO and RhD blood grouping was performed on 9,280 continuous voluntary and replacement donors. For other rare blood groups, 508 ACD blood samples were obtained from the donors at the Blood Bank of the Department of Transfusion Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Blood group antigens were determined by tube method using anti-sera (Bio-Rad, USA), and the phenotype frequencies were expressed as percentages.ResultsGroup B (37.39%) was the most common, followed by group O (31.85%). R1R1 and rr were the most common phenotypes amongst Rh positive and Rh negative groups, respectively. A rare phenotype R2Rz was found in one donor. For Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b+) were the most common phenotypes (46.06% and 48.03%, respectively). The most common phenotypes for MNSs, Lu, and Kell blood groups were M+N+, S-s+, Lu (a-b+), and K-k+, respectively. A very rare case of Fy (a-b-) and Jk (a-b-) was found in a single donor.ConclusionThis study is the first small step to create a rare donor data bank and to prepare indigenous cell panels to provide compatible blood to all multi-transfused alloimmunized patients.

Phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

“… a Fongsarun et al, , b Musa et al, , c Lin et al, , d Broadberry et al, 1994, e Yu et al, , f Makroo et al, , g Agarwal et al, . …”

Phenotypic Profile of Kell Blood Group System among Saudi Donors at King Abdulaziz Medical City-Riyadh

“…[13,14] The frequency of Cellano (k) antigen among the donors was 97% as compared to the findings in Sudanese and Indians where the respective prevalence is shown to be 99.6% and 100%. [13,14] The frequency of K-k+ phenotype (81.5%) is found significantly lower among the Saudi donors, as compared to Indians, which was 98.03%. [14] The frequency of Kp a antigen among donors in the blood transfusion services center located in KAMC was 11.7%.…”

“…[13,14] The frequency of K-k+ phenotype (81.5%) is found significantly lower among the Saudi donors, as compared to Indians, which was 98.03%. [14] The frequency of Kp a antigen among donors in the blood transfusion services center located in KAMC was 11.7%. It is near frequent to American population (4%), while it is not compatible with Sudanese population (99.8%).…”

Distribution of ABO and Rhesus Blood Groups among Selected Tribes in Adamawa State, Nigeria

“…It is well reported that differences in distribution of ABO blood groups exist, both within and among tribal groups of diverse geographical areas of the world [3,[7][8][9][10]. Some variations may even occur within small regions [11]. In Nigeria, The pattern of distribution of the ABO and Rhesus blood varies from region to region as reported in Ogbomosho, south-west region [12], Niger Delta, south-south region [13], Gusau, North-west region [14].…”