Blood microRNA changes in depressed patients during antidepressant treatment

Bocchio-Chiavetto, Luisella; Maffioletti, Elisabetta; Bettinsoli, Paola; Giovannini, C; Bignotti, Stefano; Tardito, Daniela; Corrada, Dario; Milanesi, Luciano; Gennarelli, Massimo

doi:10.1016/j.euroneuro.2012.06.013

Cited by 209 publications

(147 citation statements)

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“…Recently, two studies have examined circulating miRNA expression in the blood in patients with major depressive disorder [31,33] and found some dysregulated miRNAs. However, these studies only had small numbers of patients with a focus on major depressive disorders.…”

Section: Introductionmentioning

confidence: 99%

Circulating microRNA-144-5p is associated with depressive disorders

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Circulating microRNA-144-5p is associated with depressive disorders

et al. 2015

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“…Nekoliko studija pokazalo je da se epigenetički mehanizam ovakvog djelovanja antidepresiva temelji na modifikaciji histona, točnije -sniženoj trimetilaciji lizilnog ostatka 27 u histonu H3 (H3K27me3), u promotoru egzona IV gena BDNF 43 . Nadalje, djelovanje antidepresiva escitaloprama (SSRI) tijekom 12 tjedana liječenja, uzrokovalo je razlikovnu ekspresiju 30 različitih molekula miR, od čega su 28 bile povišene, a dvije izrazito smanjeno eksprimirane 44 . Za neke je od ovih, pojačano izraženih miR molekula (miR-132, miR-26a, miR26b i miR-182) poznato da su uključene u regulaciju neurogeneze i plastičnosti sinapsi, te razine proteina BDFN-a 45 .…”

Section: Antidepresivi Mijenjaju Epigenom -"Stari Izazovi Nove Mogućunclassified

Epigenetics and major depression disorder

2017

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Sažetak. Veliki depresivni poremećaj (MDD, od engl. Major Depressive Disorder) jedan je od najčešćih psihosomatskih poremećaja, sa snažnom tendencijom porasta broja oboljelih. Do 2020. godine mogao bi postati drugi najveći zdravstveni svjetski problem. Uzroci nastanaka bolesti, kao i klinička slika, vrlo su složeni. Ovakva složenost posljedica je aktivnosti velikog broja gena, od kojih svaki "pridonosi" nastanku i izražaju bolesti s relativno malim udjelom. Sve veći broj rezultata mnogih studija upućuje na važnost epigenetičkih mehanizama regulacije aktivnosti gena, kao poveznicu bioloških i drugih čimbenika koji se povezuju s nastankom depresije. Većina istraživanja pokazuje uzročno-posljedičnu vezu između različitih bioloških i psihosocijalnih čimbenika, s jedne strane, te međuovisne promjene obrazaca metilacije/demetilacije molekule DNK i promjene koda histona, s druge strane. Sve je više podataka o značajnoj ulozi različitih nekodirajućih molekula RNK u nastanku depresivnog poremećaja. Konačno, pokazalo se da mnogi antidepresivi djeluju na epigenom. Ovaj učinak otvara potpuno novo poglavlje u razumijevanju patogeneze i epigenetičke podloge liječenja depresivnog poremećaja.Ključne riječi: antidepresivi; epigenetika; stres; veliki depresivni poremećaj Abstract. Major Depressive Disorder (MDD) represents one of the most common psychosomatic disorders with a pronounced increasing incidence. It is expected to become the number two major world health problem by 2020. The causes of MDD as well as its clinical features are very complex. The probable reason for such complexity relates to a large number of genes, being involved in a condition where each gene makes only a minor contribution to the MDD etiology and clinic phenotypes. An increasing number of studies published during last decade have pointed out the importance of epigenetic regulatory mechanisms in affecting gene activity as well as constituting a possible link between biological and other factors related to MDD. Most of the studies have shown causality between different, MDD related biological and psycho-social factors. They have also described mutually controlled processes involved in the regulation of DNA methylation and establishment of histone code. There is a growing body of evidence on the significant role of non-coding RNA molecules in the ethiopathogenesis of MDD. Finally, it was shown that many antidepressive agents exert much influence on the epigenome. Such activity opens a new chapter in understanding the MDD pathogenesis and the basis for epigenome-reshaping related therapy.

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“…miRNA changes were examined in blood from 10 patients with MDD following 12 weeks of administration of the SSRI escitalopram. After treatment, 28 miRNAs were upregulated, including the BDNF-related miR-132, while two miRNAs, miR-34c-5p and miR-770-5p, were robustly downregulated (Bocchio-Chiavetto et al, 2013). Predicted target genes included growth factors such as BDNF and vascular endothelial growth factor, calcium channels and neurotransmitter receptors.…”

Section: Tablementioning

confidence: 99%

“…Few studies to date have reported on the epigenetic effects of antidepressant treatment in humans (Belzeaux et al, 2012;Bocchio-Chiavetto et al, 2013;Chen et al, 2011;Lopez et al, 2013;Sharma et al, 2006) (Table 4). Chen et al (2011) reported an increase in BDNF expression in the prefrontal cortex postmortem that was associated with a decrease in gene-repressing methylation of histone 3 at lysine 27 in patients taking a variety of antidepressants (Chen et al, 2011).…”

Section: Tablementioning

confidence: 99%

“…This was accompanied by a decrease in methylation of histone 3 at lysine 27 primarily in blood plasma in patients that were drug responders. miRNA changes following antidepressant treatment have been reported in two studies (Belzeaux et al, 2012;Bocchio-Chiavetto et al, 2013). miRNA changes were examined in blood from 10 patients with MDD following 12 weeks of administration of the SSRI escitalopram.…”

Section: Tablementioning

confidence: 99%

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