The studies of teacher/academician's stress have found several sources of job stress. Several significant stressors that consistently increase job stress such as poor working conditions, lack of support from management, lack of appreciation and benefits, limited participation in decision making, and lack of training how to cope with job stress. The present study also investigates how role stressors, job insecurity, leadership practices, and religious coping, predict job stress among university academic staff. How interrelationship between role stressors, leadership practices to job stress is mediated by job insecurity. The samples of the study are 337 academic staffs from Jogjakarta, Indonesia. SEM analysis was used to test the hypotheses. In Jogjakarta academic staff, religious coping just significantly buffered the effect of the antecedents-job stress model, but not significantly moderated the effect of the antecedents-job insecurity model.