Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

Samanidis, George; Gkogkos, Anastasios; Bousounis, Stefanos; Alexopoulos, Leonidas G.; Perrea, Despina

doi:10.14740/cr1121

Cited by 4 publications

(3 citation statements)

References 37 publications

(64 reference statements)

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“…A multiethnic cohort study with 1913 participants showed that resistin was an independent risk factor for CAD, MI, and HF but not AF ( 48 ). Two studies suggested that elevated levels of circulating resistin were related to AF, whereas the impact on permanent AF yielded opposite results ( 49 , 50 ). The discrepancy in results may be due to measurement error, residual confounding, or reverse causality in the observational researches.…”

Section: Discussionmentioning

confidence: 99%

Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study

Chen

Zhang

Yidilisi

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Observational studies have suggested associations between adipokines and cardiovascular disease (CVD), but the roles of certain adipokines remain controversial, and these associations have not yet been ascertained causally. Objective To investigate whether circulating adipokines causally affect the risk of CVD using two-sample Mendelian randomization (MR). Methods Independent genetic variants strongly associated with adiponectin, resistin, chemerin and retinol binding protein 4 (RBP4) were selected from public genome-wide association studies. Summary-level statistics for CVD, including coronary artery disease (CAD), myocardial infarction, atrial fibrillation (AF), heart failure (HF), stroke and its subtypes were collected. The inverse-variance weighted and Wald ratio methods were used for the MR estimates. The MR-PRESSO, weighted median, MR-Egger, leave-one-out analysis, MR Steiger and colocalization analysis were used in the sensitivity analysis. Results Genetically predicted resistin levels were positively associated with AF risk (OR 1.09; 95% CI, 1.04 to 1.13; P = 4.1×10 -5), which was attenuated to null after adjusting for blood pressure. We observed suggestive associations between higher genetically predicted chemerin levels and an increased risk of CAD (OR 1.27; 95% CI, 1.01 to 1.60; P = 0.040), higher genetically predicted RBP4 levels and an increased risk of HF (OR 1.14; 95% CI, 1.02 to 1.27; P = 0.024). There was no causal association between genetically predicted adiponectin levels and CVD risk. Conclusions Our findings reveal the causal association between resistin and AF, probably acting through blood pressure, and suggest potential causal associations between chemerin and CAD, RBP4 and HF.

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Section: Discussionmentioning

confidence: 99%

Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study

Chen

Zhang

Yidilisi

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Twenty eight patients with AF presented higher serum resistin levels. 68 There is a practical aspect of measuring resistin levels in epicardial tissue (sectioned during cardiovascular surgery) as that may be an indirect predictor for AF during postoperative care. In our previous study, 46 patients after coronary artery bypass grafting (CABG) were monitored for 3 days after the surgery and divided into 2 groups (with AF after the surgery and without AF after surgery).…”

Section: The Impact Of Resistin Levels On the Etiology Of Atheroscler...mentioning

confidence: 99%

Role of resistin in cardiovascular diseases: Implications for prevention and treatment

Rachwalik

Hurkacz

Sienkiewicz-Oleszkiewicz

et al. 2021

Adv Clin Exp Med

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Cardiovascular diseases (CVDs) are associated with socioeconomic and, most importantly, with clinical problems. Accordingly, the identification of early and specific biomarkers indicating metabolic changes that underlie disease development and/or progression is important and may improve preventive and treatment strategies. A recently discovered protein -resistin (ADSF, FIZZ3) -whose expression is increased in carbohydrate metabolism and adipose tissue disorders, seems to be worth of interest in this context. The current publication was based on a detailed review of available literature, including Medline, EBSCO, Scopus, and Cochrane Library databases. The search period was between January 1, 2001 and December 20, 2020. The following keywords were used: "resistin", "resistin AND cardiology" and "resistin AND cardiosurgery". Our review covered a total of 4476 records, 594 of which were review publications. The presented article summarizes the current knowledge on the role of resistin in prevention and treatment of CVDs. Available literature shows that resistin may be a predictor for various pathological states; however, data from some studies on the pathophysiological mechanisms of action are contradictory. There is a need for further investigations to explore the exact role of resistin in CVDs.

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“…In PVAT, adipose tissue is in contact with epicardial coronary arteries. Thus, chronic local inflammation may influence the abnormal development of fibrous tissue and infiltration of conducting tissue [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the usefulness of determining the level of selected inflammatory biomarkers and resistin concentration in perivascular adipose tissue and plasma for predicting postoperative atrial fibrillation in patients who underwent myocardial revascularisation

et al. 2023

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Background The development of coronary artery disease (CAD) is related to the impaired quantity and composition of inflammatory proteins found in plasma and tissue, such as interleukin 6 (IL-6), adipokines, and resistin. Therefore, the level of plasma resistin in patients with advanced CAD could be indicative of the condition of epicardial adipose tissue and thus have an impact on the frequency and severity of postoperative complications in the form of paroxysmal atrial fibrillation. Methods The study included 108 patients who qualified for elective coronary artery bypass grafting (CABG) surgery from 2017 to 2020 and were categorized into two groups. The first group consisted of patients who developed atrial fibrillation in the postoperative period – the AF group, and the second group included patients who did not have arrhythmia – the non-AF group. The analysis incorporates the history, course of treatment, anthropometric characteristics of the test subjects, biochemical laboratory tests, and echocardiography. Perivascular adipose tissue (PVAT) sections were surgically harvested from the area of the left coronary trunk. Results The resistin levels in the PVAT were significantly higher in the AF group than in the non-AF group (P = 0.000015). Similarly, plasma resistin levels increased significantly in the AF group compared to the non-AF group (P = 0.044). The values of other analyzed variables were not significantly different (analysis performed using the Mann–Whitney U test). Spearman’s rank-order correlation technique found a correlation between resistin in PVAT and plasma (r = 0.5933; P < 0.0001) in the whole study group, as well as in the AF group (r = 0.4782; P = 0.021) and the non-AF group (r = 0.4938; P < 0.0001). A correlation arose between the level of resistin in PVAT and the level of hsCRP (r = 0.3463; P = 0.005) in the whole study group and the non-AF group (r = 0.4448; P = 0.0011); however, no such correlation appeared in the AF group (r = 0.3076; P = 0.306). Conclusions Elevated levels of plasma resistin, which reflect PVAT resistin levels in patients qualified for myocardial revascularisation, may be associated with postoperative atrial fibrillation complications.

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Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

Cited by 4 publications

References 37 publications

Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study

Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study

Role of resistin in cardiovascular diseases: Implications for prevention and treatment

Evaluation of the usefulness of determining the level of selected inflammatory biomarkers and resistin concentration in perivascular adipose tissue and plasma for predicting postoperative atrial fibrillation in patients who underwent myocardial revascularisation

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