Blood pressure and growth at 6 years of age among offsprings of mothers with hypertension of pregnancy

Palti, Hava; Rothschild, Ety

doi:10.1016/0378-3782(89)90061-3

Cited by 58 publications

(31 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are in line with other studies that have reported positive associations between hypertensive disorders of pregnancy and offspring BP 7, 8, 10, 11, 28. Our study extends this previous work by suggesting that family adiposity does not confound these associations.…”

Section: Discussionsupporting

confidence: 93%

“…Oglaend et al found an association of increased systolic blood pressure (SBP) in early adolescence in offspring of preeclamptic pregnancies, which attenuated after adjustment for maternal body mass and blood pressure 6. Palti and Rothschild reported that 6-year-old boys, but not girls, born to mothers with preeclampsia had higher diastolic blood pressures (DBP) than control children born to mothers without preeclampsia 7. By contrast Seidman et al concluded that 17-year-old daughters of mothers with preeclampsia had higher SBP and DBP than their control females, whereas only the mean SBP differed between the males 8.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preeclampsia and Gestational Hypertension Are Associated With Childhood Blood Pressure Independently of Family Adiposity Measures

Geelhoed

Fraser²,

Tilling³

et al. 2010

Circulation

193

170

View full text Add to dashboard Cite

Background Offspring of women with hypertensive disorders of pregnancy are at increased risk of cardiovascular complications later in life, but the mechanisms underlying these associations are unclear. Our aim was to examine whether adjusting for birthweight and familial adiposity changed the association of hypertensive disorders of pregnancy with offspring blood pressure. Methods and Results Using data from 6,343 nine-year-old participants of the Avon Longitudinal Study of Parents and Children, we examined the association between hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) and offspring blood pressure. Preeclampsia and gestational hypertension were both associated with systolic (SBP) and diastolic blood pressure (DBP) in the nine-year-old offspring: after adjustment for parental and own adiposity, as well as other potential confounders, mean difference in SBP of 2.05 mmHg (95% CI: 0.72, 3.38) and 2.04 mmHg (95% CI: 1.42, 2.67), respectively for preeclampsia and gestational hypertension, compared to those with no hypertensive disorders of pregnancy. Equivalent results for DBP were 1.00 mmHg (95% CI: -0.01, 2.10) and 1.07 mmHg (0.60, 1.54). The association of preeclampsia with offspring SBP and DBP attenuated towards the null with further adjustment for birthweight and gestational age, whereas these adjustments did not attenuate the association of gestational hypertension with offspring blood pressure. Conclusions The associations of hypertensive disorders of pregnancy with higher offspring BP are not explained by familial adiposity. The mechanisms linking preeclampsia and gestational hypertension with offspring BP may differ, with the former at least in part mediated by the effect of preeclampsia on intrauterine growth restriction.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Preeclampsia and Gestational Hypertension Are Associated With Childhood Blood Pressure Independently of Family Adiposity Measures

Geelhoed

Fraser²,

Tilling³

et al. 2010

Circulation

193

170

View full text Add to dashboard Cite

show abstract

“…Furthermore, such women have also been shown to have increased risk for renal diseases, such as, Focal segmental glomerulosclerosis (FSGS) and microalbuminuria. The children born after a pregnancy complicated by preeclampsia have also been shown to be at high risk for complications like diabetes mellitus, cardiovascular disease, and hypertension [23, 24]. The pathogenesis of this increased risk has not been defined, but suggested contributing factors include fetal malnutrition, epigenetic modification, and postnatal growth acceleration [25].…”

Section: Pathogenesis Of Preeclampsia and Hemodynamic Changesmentioning

confidence: 99%

Preeclampsia 2012

Eiland

Nzerue

Faulkner

2012

Journal of Pregnancy

207

169

View full text Add to dashboard Cite

Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.

show abstract

“…The majority of studies (Palti and Rothschild, 1989; Seidman et al, 1991; Tenhola et al, 2003, 2006; Vatten et al, 2003; Swarup et al, 2005; Hiller et al, 2007; Oglaend et al, 2009; Kvehaugen et al, 2010; Lazdam et al, 2010; Palmsten et al, 2010; Lawlor et al, 2012), but not all (Ounsted et al, 1983; Jayet et al, 2010; Belfort et al, 2012; Lawlor et al, 2012) report that children and adolescents who were exposed to preeclampsia or hypertension in pregnancy exhibit higher systolic and diastolic blood pressure compared with non-exposed children or adolescents. These studies were reviewed in a recent meta-analysis (Davis et al, 2012a), which included individuals aged 4–30 years, born at term from preeclamptic pregnancies.…”

Section: Developmental Origins Of Adult Disease After Preeclampsiamentioning

confidence: 99%

Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

et al. 2014

View full text Add to dashboard Cite

Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspring born from preeclamptic pregnancies has been associated with an increased risk of cardiovascular disease, including hypertension, later in life. Interestingly, diminished endothelial function, manifested by low angiogenic capacity, leads to hypertension in animal studies. Recently, we have shown that the adenosine receptor A2A/nitric oxide/vascular endothelial growth factor axis is reduced in human umbilical vein endothelial cells derived from preeclamptic pregnancies, an effect correlated with gestational age at onset of preeclampsia. We and others suggested that impaired vascular function might be associated with high cardiovascular risk in offspring exposed to pregnancy diseases. However, we are not aware of any studies that examine impaired adenosine-mediated angiogenesis as a possible link to hypertension in offspring born from preeclamptic pregnancies. In this review, we present evidence supporting the hypothesis that reduced adenosine-mediated angiogenesis during preeclamptic pregnancies might be associated with development of hypertension in the offspring.

show abstract

Blood pressure and growth at 6 years of age among offsprings of mothers with hypertension of pregnancy

Cited by 58 publications

References 9 publications

Preeclampsia and Gestational Hypertension Are Associated With Childhood Blood Pressure Independently of Family Adiposity Measures

Preeclampsia and Gestational Hypertension Are Associated With Childhood Blood Pressure Independently of Family Adiposity Measures

Preeclampsia 2012

Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

Contact Info

Product

Resources

About