Blood Pressure Elevation and Renal Pathology in Rats Fed Simulated Japanese Diets

Hilker, Doris M.; Wenkam, Nao S.; Lichton, I. J.

doi:10.1093/jn/87.4.371

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…It is reported that the high salt diet induces hypertension and also elevates the concentration of serum cholesterol in rats (Koyanagi et al 1959;Hilker et al 1965). In the present experiment, both the serum and liver cholesterol levels were apparently increased by the ad libitum administration of 1% saline.…”

Section: Discussionsupporting

confidence: 54%

Effect of Dietary Casein, Fats and Saline on the Atheromatous Lesions of the Aorta, Coronary Arteries and Renal Small Arteries in Rats

Nakadate

1973

Tohoku J. Exp. Med.

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. Effect of Dietary Casein, Fats and Saline on the Atheromatous Lesions of the Aorta, Coronary Arteries and Renal Small Arteries in Rats. Tohoku J. exp. Med., 1973, 111 (2), 157-174 -Male albino rats of the Donryu strain weighing 120 g were fed high-fat (40%) atherogenic diets with two casein levels for 16 weeks. Either hydrogenated kapok oil or butter fat was used in the diet. One % saline or tap water was offered as drinking water. The rats fed high casein (31%) diets showed remarkably high growth, and their serum cholesterol levels were about one half of those of low casein (11%) groups. One % saline increased slightly the serum cholesterol levels. Fatty lesions of the arteries in the heart, kidneys, aortae, and renal glomeruli of rats fed high casein diets were milder compared to those of low casein groups, and all the lesions except for those of renal glomeruli were potentiated by the saline administration. The lesions of coronary arteries, cardiac muscles, and glomeruli of the hydrogenated oil group were severer than those of the butter fat group although serum cholesterol level of the former was somewhat lower than the latter. However, atheromatous lesion of aortae was severer in the butter fat group. No intimal lesion of the arteries was observed in kidneys and the lipids in media were seen along adventitia.atherosclerosis; casein; fat source; salineIt has been about twenty years since the histological lesions comparable to human atherosclerosis were produced in rats by dietary means (Hartroft et al. 1952;Wissler et al. 1954). Several diet compositions have been proposed as causative agents to produce the lesions and some knowledge has accumulated about the dietary factors which are considered to be related with the arterial lesions (Thomas et al. 1959: Gresham andHoward 1960).

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Section: Discussionsupporting

confidence: 54%

Effect of Dietary Casein, Fats and Saline on the Atheromatous Lesions of the Aorta, Coronary Arteries and Renal Small Arteries in Rats

Nakadate

1973

Tohoku J. Exp. Med.

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“…Although the basic pattern of mineral metabolism is similar in various mammalian species, no direct com parisons and extrapolations can be made in applying the results of animal experiments to man. On the other hand, only by simulating human diets as closely as possible one may include in animal studies all the possible elements of interference and interrelationships that normally occur in human nutrition [11][12][13]. The absorption and utili zation of iron, for example, is a function of innumerable dietary fac- tors, the integration of which still remains obscure.…”

Section: Resultsmentioning

confidence: 99%

Bioevaluation of Dietary Iron in Growing Rats

Ahlström¹,

Koivistoinen²

1970

Ann Nutr Metab

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The effects of simulated Finnish diets with and without iron and copper supplementations were studied on four groups of growing male rats. Although otherwise in good health, the rats on the basal human diet (27 mg Fe/kg and 2.2 mg Cu/kg dry weight) became slightly anemic. The rats on the iron-supplemented diet (56 mg Fe as FeCl₃/kg) had a normal hematological picture, and significantly higher iron stores and lower radioiron absorption percentages than the rats of the basal group. The rats receiving the basal diet plus copper (6.0 mg Cu/kg) consumed more food but had a low food efficiency. The administration of copper to both the basal and iron-supplemented diets resulted in a slight, although statistically nonsignificant trend towards higher hematological values and better utilization of iron. In conclusion, judged from the responses obtained by supplementations, the simulated Finnish diet turned out to be short of iron and marginal in copper for the growing male rat. The significance of these observations in human nutrition is difficult to evaluate at present.

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Nutrition and diseases of women: cardiovascular disorders.

Preuss

1993

Journal of the American College of Nutrition

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Studies of prevention, diagnosis, and intervention for coronary heart disease and hypertension have either been conducted largely in men, or gender differences have not always been fully sought. This has added to a general perception that coronary artery disease is basically a male affliction despite the fact that coronary artery disease is the leading cause of death among women, especially elderly women. Many risk factors among women are similar to men, i.e., high blood pressure (BP), elevated serum cholesterol levels, and cigarette smoking; however, women compared to men have greater incidence of diabetes mellitus, congestive heart failure, and hypertension as they become older. The risk of cardiovascular disorders can be reduced by postmenopausal estrogen replacement, exercising sufficiently, and ceasing smoking. In addition, good nutrition, taking into consideration the proper amount and forms of calories, sodium, potassium, calcium, magnesium, and macronutrients to maintain an ideal lipid profile and BP, is helpful in preventing cardiovascular perturbations.

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Blood Pressure Elevation and Renal Pathology in Rats Fed Simulated Japanese Diets

Cited by 8 publications

References 16 publications

Effect of Dietary Casein, Fats and Saline on the Atheromatous Lesions of the Aorta, Coronary Arteries and Renal Small Arteries in Rats

Effect of Dietary Casein, Fats and Saline on the Atheromatous Lesions of the Aorta, Coronary Arteries and Renal Small Arteries in Rats

Bioevaluation of Dietary Iron in Growing Rats

Nutrition and diseases of women: cardiovascular disorders.

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