Blood pressure lowering effect of scopoletin on oxidative stress-associated hypertensive rats

ARMENIA, Armenia; HIDAYAT, Rahmat; MEILIANI, Meiliani; Yuliandra, Yori

doi:10.12991/jrp.2019.131

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…SBP, DBP, and MAP of the animal were increased up to 151 mmHg, 118 mmHg, and 128 mmHg, respectively. This result is in line with earlier studies using the same inductor [16], [17], [18]. Prednisone is a glucocorticoid hormone with a 0.8 index of mineralocorticoid [19].…”

Section: Discussionsupporting

confidence: 92%

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

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Khairunnisa

Rosyari

et al. 2022

Open Access Maced J Med Sci

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Introduction: Purified gambier (Uncaria gambir Roxb.) is potential for treating hypertension based on its antioxidant bioactivity. In this study, we investigated the antihypertensive performances of purified gambier on hypertensive rats and the correlation with its antioxidant activity. Methods: Rats (2-3 months old and the bodyweight of 200-250 g) were divided into five groups. Groups 1, 2, and 3 were treated orally with water suspension of purified gambier at doses of 2.5; 5; and 10 mg/kg BW once a day for 14 days, group 4 and 5 were acted as positive control (treated with vehicle) and captopril treated group (comparison) respectively. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), blood flow (BF) and blood volume (BV) were recorded once a day before and 1,3,7 and 14 days after commencement. The blood was taken before and at the end of recording for the plasma NO measurement. Two-way ANOVA was used to analyze the changes of those parameters, except for plasma NO analyzes by one-way ANOVA, followed by Duncan multirange test (95% confidence interval). Results: The study showed that significant antihypertensive effects (p<0.05), influenced by doses and gambier administration duration. The plasma NO of animals was increased after administration of purified gambier (p<0.05), although there was no significant difference in plasma NO in doses variation. Conclusion: These indicated that purified gambier proceed antioxidant associated antihypertensive effects at doses of 2.5 – 10 mg/kg BW when administered for 14 days on the salt-prednisone induced hypertensive rats. KEYWORDS: antioxidant, antihypertensive, purified gambier, Uncaria gambir Roxb., salt-prednisone induced, hypertension rat

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Section: Discussionsupporting

confidence: 92%

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Permatasari

Khairunnisa

Rosyari

et al. 2022

Open Access Maced J Med Sci

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“…Penggunaan metode langsung pengukuran tekanan darah telah disarankan sebagai standar baku karena menunjukkan indikasi langsung ke sistem peredaran darah dan informasi denyut-demi-denyut dengan lebih akurat. [22][23][24] (Tabel 1)…”

Section: Efek Klinis Skopoletin Dalam Menurunkan Tekanan Darah Dan De...unclassified

“…Hasil ini menunjukkan bahwa skopoletin tidak signifikan mempengaruhi detak jantung sehingga detak jantung menjadi stabil. [22] (Gambar 3) Gambar 3. Perbandingan Efek Terapi terhadap Tekanan Darah pada Model Hipertensi yang Berbeda.…”

Section: Efek Klinis Skopoletin Dalam Menurunkan Tekanan Darah Dan De...unclassified

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Efek Skopoletin dari Ekstrak Buah Mengkudu (Morinda Citrifolia) sebagai Modalitas Herbal dalam Penanganan Preeklamsia

Christopher¹,

Debora²,

Louisa³

2022

ESSENTIAL

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ABSTRACT Introduction: Preeclampsia is a disorder which usually occurs in normotensive women and characterized by hypertension. Preeclampsia often causes morbidity and mortality in both mother and fetus. Lots of deaths have been caused by preeclampsia every year. Thus, good and proper treatment need to be done. The aim of this writing is to find out and make a literature review about preeclampsia’s herbal-based treatment which is safe for pregnant women. Discussion: Many factors take part in the pathogenesis of preeclampsia, including increased oxidative stress and decreased nitric oxide (NO). Increased oxidative stress can cause placental dysfunction which will cause clinical manifestations of preeclampsia. Decreased NO can also cause clinical manifestations of preeclampsia. Scopoletin antioxidant from Morinda citrifolia fruit extract is able to prevent cell damage caused by oxidative stress and prevent inactivation of NO due to free radicals. Scopoletin was proven to significantly decrease blood pressure in rats with oxidative stress-related hypertension (PNL) and to significantly increase NO in the PNL group and the general hypertension group (PN). Conclusion: Treatment of preeclampsia can be done by scopoletin antioxidant, resulting in the effect on systolic and diastolic blood pressure and mean arterial pressure. Scopoletin also increases NO, resulting in a vasodilation effect. This writing is expected to be a help in advancing the treatment of preeclampsia in the future. Keywords: Morinda citrifolia, preeclampsia, scopoletin

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“…Complications of diabetes have emerged as a global health issue, as well as the leading cause of morbidity and mortality in diabetic patients in the absence of a viable treatment approach. Diabetes is frequently associated with long-term microvascular and macrovascular problems, such as nephropathy, retinopathy and neuropathy [7]. Diabetic nephropathy (DN) is a common microvascular congestion in people with diabetes, shown by proteinuria, which leads to impaired kidney function [8].…”

Section: Introductionmentioning

confidence: 99%

Purified Gambir (Uncaria Gambir (Hunter) Roxb.) Attenuate Renal Function in Alloxan-Induced Diabetic Male Rats

RACHMAINI,

ARMENIA,

ABDILLAH

2024

Int J App Pharm

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Objective: Diabetes and its vascular complications could prevent by antioxidants. Purified gambir is the purified extract of Uncaria gambir (Hunter) Roxb, which contains more than 90% catechins and scientifically work as antioxidant. This study aimed to determine the effect of purified gambir on renal function in alloxan-induced diabetic Wistar Kyoto rats. Methods: Diabetic rats were induced by alloxan 125 mg/kgBW by intraperitoneal injection. Forty-five diabetic rats were divided into five groups, diabetic control group treated with vehicle, a positive control group treated with glibenclamide at dose 0.45 mg/kgBW, and treatment groups of purified gambir at doses of 2.50, 5, and 10 mg/kgBW for 14 d. Blood glucose, water intake, urine volume, creatinine clearance, renal ratio, and urine density were measured on day 3, 7, and 14. All data were analyzed by two-way ANOVA followed by Duncan Multiple Range Test. Results: Purified gambir significantly lower blood glucose (p<0.05) and had a significant effect (p<0.05) on renal function parameters in diabetic rats. Duration of treatment purified gambir in diabetic rats had a significant effect (p<0.05) on water intake, urine volume, creatinine clearance and renal ratio. Conclusion: This result show that purified gambir at dose 2.5 mg/kgBW increased the renal function of diabetic rats, in contrast, purified gambir at dose 5 and 10 mg/kgBW attenuate renal function of diabetic rats

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Blood pressure lowering effect of scopoletin on oxidative stress-associated hypertensive rats

Cited by 11 publications

References 27 publications

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Efek Skopoletin dari Ekstrak Buah Mengkudu (Morinda Citrifolia) sebagai Modalitas Herbal dalam Penanganan Preeklamsia

Purified Gambir (Uncaria Gambir (Hunter) Roxb.) Attenuate Renal Function in Alloxan-Induced Diabetic Male Rats

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