Blood Pressure-Lowering Effects of Lifestyle Modification: Possible Involvement of Nitric Oxide Bioavailability

Ohta, Masanori; Nanri, Hiroki; Matsushima, Yasuyuki; Sato, Yuji; Ikeda, Masaharu

doi:10.1291/hypres.28.779

Cited by 38 publications

(27 citation statements)

References 43 publications

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“…It can be suggested, therefore, that the reduced NOx concentration observed in G4 group at baseline are more related to genetic factors than NO-scavenging effect. Although this mechanism is not completely clear, it has been described that AEX induces a substantial upregulation on antioxidant system which in turn will regulate the intracellular O 2 -Á content and consequently NO availability in adults (Park et al 2005;Gomes et al 2008) and older subjects (Campo et al 2005;Guzik et al 2005;Ohta et al 2005;Vaneckova et al 2005;Fukai 2007). In fact, we observed a marked reduction on blood T-BARS level after AEX, but there were no changes on ecSOD activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people

2010

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The polymorphisms of endothelial nitric oxide synthase (eNOS) are associated with reduced eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) production, oxidative stress and blood pressure. The purpose of this study was to investigate the effect of AEX on the relationship among blood pressure, eNOS gene polymorphism and oxidative stress in pre-hypertensive older people. 118 pre-hypertensive subjects (59 ± 6 years) had blood samples collected after a 12 h overnight fast for assessing plasma NO metabolites (NOx) assays, thiobarbituric acid reactive substances (T-BARS) and superoxide dismutase activity (ecSOD). eNOS polymorphism (T-786C and G-894T) was done by standard PCR methods. All people were divided according to the genotype results (G1: TT/GG, G2: TT/GT + TT, G3: TC + CC/GG, G4: TC + CC/GT + TT). All parameters were measured before and after 6 months of AEX (70% of VO(2 max)). At baseline, no difference was found in systolic and diastolic blood pressure, ecSOD and T-BARS activity. Plasma NOx levels were significantly different between G1 (19 ± 1 μM) and G4 (14.2 ± 0.6 μM) and between G2 (20.1 ± 1.7 μM) and G4 (14.2 ± 0.6 μM). Therefore, reduced NOx concentration in G4 group occurred only when the polymorphisms were associated, suggesting that these results are more related to genetic factors than NO-scavenging effect. After AEX, the G4 increased NOx values (17.2 ± 1.2 μM) and decreased blood pressure. G1, G3 and G4 decreased T-BARS levels. These results suggest the AEX can modulate the NOx concentration, eNOS activity and the relationship among eNOS gene polymorphism, oxidative stress and blood pressure especially in C (T-786C) and T (G-894T) allele carriers.

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Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people

2010

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“…Apparently these participants will not go for a routine blood pressure check based on their belief. It was also noted that majority of the participants could not differentiate between daily activities and regular exercise as it was strongly agreed that daily activities was same as regular exercises unlike in the study by Ohata et al (2005) where all participants appreciated a 12 week …”

Section: Discussionmentioning

confidence: 83%

Knowledge, attitude to hypertension and lifestyle habits of rural dwellers in Owerre-Nkwoji, Imo State Nigeria

Osuala¹,

Abimbola²,

Kadiri³

2014

J. Public Health Epidemiol.

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Hypertension accounts for 13% of global mortality, with 25% prevalence in Nigeria. Current trends in management is lifestyle modification. Information on lifestyle habits is needed for effective intervention programe. A study was done among rural dwellers between ages 20 and 75 in Owerre-Nkwoji, Imo State, to determine their knowledge, attitude to hypertension and lifestyle habits. Information gathered would be used to plan an intervention programe to increase awareness and promote healthy lifestyles. The study design is descriptive and simple random sampling method was used in selection of village for the study. An instrument used was a questionnaire with sections on background, knowledge, attitude and lifestyle habits. Descriptive and inferential analysis was done. Findings revealed awareness on hypertension as 116 (96.7%). 88 (73%) were aware of sudden death and stroke in the community. Participants with high knowledge were 32 (26.7%), average 40 (33.3%) and low 48 (40.0%). There was positive attitude to hypertension prevention. Sixty-four (53.3%) believed that hypertension can be sent by one's enemy. Unhealthy lifestyles elicited include use of alcohol, table salt and stimulants. There is a need to correct misconceptions. Readiness for improved health was elicited. As people recognize that lifestyles and behavior significantly affect health, they may assume responsibility for avoiding high risk behaviors.

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“…There is growing evidence to indicate that chronic exercise increases the antioxidant defense system in human blood vessels by increasing the activity of ecSOD 8,14,37 . Aerobic exercise can increase the activity of ecSOD and potentially increase the bioavailability of NO 11,20 .…”

Section: Figure 2 -Blood Flow (Panel a And B) And Vascular Resistancementioning

confidence: 99%

Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

Zago¹,

Kokubun²,

Fenty-Stewart³

et al. 2010

Arq. Bras. Cardiol.

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Blood Pressure-Lowering Effects of Lifestyle Modification: Possible Involvement of Nitric Oxide Bioavailability

Cited by 38 publications

References 43 publications

Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people

Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people

Knowledge, attitude to hypertension and lifestyle habits of rural dwellers in Owerre-Nkwoji, Imo State Nigeria

Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

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