Blood Pressure Measurements and Carotid Intima Media Thickness in Hemodialysis Patients

Ekart, Robert; Hojs, Radovan; Pečovnik-Balon, Breda; Bevc, Sebastjan; Dvoršak, Benjamin

doi:10.1111/j.1744-9987.2009.00726.x

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…Kaplan-Meier survival analysis revealed that patients with high IMT values had a statistically significant higher mortality caused by cardiovascular disease than patients with low IMT values [37]. Therefore, IMT measurements were included into the measures to diagnose and estimate the degree of arteriosclerosis [38].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Magnesium and Clinical Biomarkers on Inhibition of Vascular Calcification

et al. 2011

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Background: Arteriosclerosis and cardiovascular disease are strongly associated with vascular calcification. Hyperphosphatemia is an essential risk factor for increased vascular calcification. End-stage renal disease (ESRD) patients could serve as an in vivo model for accelerated calcification. This study focuses on the most likely protective effects of magnesium ion (Mg²⁺) on phosphate-induced vascular calcification ex vivo/in vitro. Furthermore, plasma Mg²⁺ concentrations of ESRD and healthy controls were investigated for association with surrogate parameters of vascular calcification in vivo. Methods: Aortic segments of male Wistar-Kyoto rats were incubated and the phosphate concentration of the medium was elevated. The aortic segments were incubated in the absence and presence of MgCl₂; tissue calcification was quantified by different methods. Serum Mg²⁺ concentrations of patients with chronic kidney disease (CKD stage 5; ESRD) and patients without CKD (controls) were associated with carotid intima media thickness (IMT) and aortic pulse wave velocity (PWV) as surrogate parameter for arteriosclerosis and arterial stiffening. Results: Incubation of aortic segments in the presence of β-glycerophosphate and NaH₂PO₄ caused an increased tissue Ca²⁺ deposition compared to control conditions. This increased amount of Ca²⁺ in the aortic rings was significantly decreased in the presence of Mg²⁺. In CKD patients, but not in controls, magnesium serum concentration was associated with the IMT of the carotid arteries. In addition, CKD patients with higher magnesium serum concentration had a significantly lower PWV. Discussion and Conclusion: Elevated phosphate concentrations in the culture media induce ex vivo/in vitro medial calcification in intact rat aortic rings in the presence of alkaline phosphatase. Mg²⁺ ions reduced ex vivo/in vitro vascular calcification despite increased phosphate concentration. This hypothesis is additionally based on the fact that CKD patients with high Mg² serum levels had significantly lower IMT and PWV values, which may result in a lower risk for cardiovascular events and mortality in these patients. Therefore, Mg²⁺ supplementation may be an option for treatment and prevention of vascular calcification resulting in a reduction of cardiovascular events in CKD patients.

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Section: Discussionmentioning

confidence: 99%

Relationship between Magnesium and Clinical Biomarkers on Inhibition of Vascular Calcification

et al. 2011

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“…15 Ekart et al found a statistically significant correlation between carotid IMT and the average one-monthly diastolic BP (P < 0.05) and ambulatory BP monitoring (P < 0.05). 16 In our study, we found that CIMT in selected patients correlated significantly with BMI (r = 0.223, p-value = 0.026), total cholesterol (r = 0.482, p-value = 0.00), LDL cholesterol (r = 0.210, p-value = 0.036), HDL cholesterol (r = -0.480, pvalue = 0.00), serum triglycerides (r = 0.636, p-value = 0.00). Similar results were observed by Szeto et al 17 In our study, it was observed that there was statistically significant difference of CIMT between diabetic and nondiabetic patient (t-value = -0.592, p-value = 0.557).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Carotid Intimal-Medial Thickness With Estimated Glomerular Filtration Rate and Cardiovascular Risk Factors in Patients of Chronic Kidney Disease

Sikri¹,

Chander²,

Singh³

et al. 2017

jemds

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BACKGROUNDChronic Kidney Disease (CKD) is associated with premature mortality, decreased quality of life and increased health care expenditures. 1,2 Many patients with CKD have cardiovascular disease and die prematurely from this condition instead of surviving long enough to face dialysis or transplantation. 3,4 Carotid Intimal-Medial Thickness (CIMT) predicts future vascular events in the general population. However, the correlation of traditional cardiovascular risk factors and estimated glomerular filtration rate in Chronic Kidney Disease (CKD) with CIMT is not studied extensively. To determine the correlation of CIMT with traditional cardiovascular risk factors like age, Body Mass Index (BMI), dyslipidaemia and estimated glomerular filtration of CKD patients, CIMT was measured by means of high-resolution B-mode ultrasonography.

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“…Isolated systolic hypertension was more prevalent compared with isolated diastolic hypertension. It was interesting finding about casual connection between carotid IMT and values of diastolic blood pressure on the hemodialysis day ABPM, interdialytic day ABPM and 48-hour diastolic blood pressure values (Ekart et al, 2009). Fig.…”

Section: Cardiovascular Mortalitymentioning

confidence: 99%

“…We also performed a cross-sectional study in which we assess the relationship between carotid IMT as a marker of asymptomatic atherosclerosis and blood pressure measurements obtained with a standard mercury sphygmomanometer before and after the hemodialysis session, the average one-monthly values of the routine blood pressure measurements and 24-and 48-hour ABPM (Ekart et al, 2009). Hypertension was defined as systolic blood pressure of 140 mmHg (ABPM ≥ 135 mmHg), diastolic blood pressure of ≥ 90 mmHg (ABPM ≥ 85 mmHg) and/or also lower levels if the patient was taking antihypertensive drugs.…”

Section: Cardiovascular Mortalitymentioning

confidence: 99%

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Blood Pressure and Hemodialysis

Ekart¹,

Bevc²,

Hojs³

2011

Special Problems in Hemodialysis Patients

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Blood Pressure Measurements and Carotid Intima Media Thickness in Hemodialysis Patients

Cited by 12 publications

References 23 publications

Relationship between Magnesium and Clinical Biomarkers on Inhibition of Vascular Calcification

Relationship between Magnesium and Clinical Biomarkers on Inhibition of Vascular Calcification

Correlation of Carotid Intimal-Medial Thickness With Estimated Glomerular Filtration Rate and Cardiovascular Risk Factors in Patients of Chronic Kidney Disease

Blood Pressure and Hemodialysis

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