Clin Physio Funct Imaging

2007

DOI: 10.1111/j.1475-097x.2007.00720.x

|View full text |Cite

|

Sign up to set email alerts

|

Blood pressure response to isometric exercise in patients with peripheral atherosclerotic disease

¹

,

Jonny Hisdal²,

Andries J. Kroese

³

et al.

Abstract: Our study indicates that the pressor response continues to be well regulated with age, also when the cardiovascular system is altered by marked atherosclerosis. The consequence is that both PAD patients and elderly controls reach higher SP values during isometric exercise due to higher SP baseline values.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion2

Introduction1

Preface1

Rp Aq1

Citation Types

Supporting

4

Mentioning

26

Contrasting

0

Unclassified

1

Year Published

2007

2007

2021

2021

Publication Types

Select...

Article8

Other1

Relationship

Self Cite0

Independent9

Authors

Journals

Cited by 36 publications

(31 citation statements)

References 55 publications

Supporting

4

Mentioning

26

Contrasting

0

Unclassified

1

Order By: Relevance

“…Indeed, we found that coronary hyperemia is also impaired in PAD during isometric handgrip exercise. While CBV responses to handgrip were attenuated in PAD, the increase in BP and HR were similar to healthy subjects, which is consistent with other studies [16]. The pressor response generated during plantar flexion exercise is greater in PAD.…”

Section: Discussionsupporting

confidence: 91%

Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease

¹

,

²

,

³

et al. 2017

Annals of Vascular Surgery

View full text Add to dashboard Cite

STRUCTURED ABSTRACT Background Peripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD. Methods Twelve patients with PAD and no overt coronary disease (65 ± 2 yr, 7 men) and 15 healthy control subjects (64 ± 2 yr, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload). A subset of subjects (N = 7 PAD, N = 8 healthy) also performed isometric handgrip exercise (40% maximum voluntary contraction to fatigue). Coronary blood velocity in the left anterior descending artery was measured by transthoracic Doppler echocardiography; blood pressure and heart rate were monitored continuously. Results Coronary blood velocity responses to 4 minutes of plantar flexion exercise (PAD: Δ 2.4 ± 1.2, healthy: Δ 6.0 ± 1.6 cm/s, P = 0.039) and to isometric handgrip exercise (PAD: Δ 8.3 ± 4.2, healthy: Δ 16.9 ± 3.6, P = 0.033) were attenuated in PAD patients. Conclusions These data indicate that coronary exercise hyperemia is impaired in PAD, which may predispose these patients to myocardial ischemia.

“…Indeed, we found that coronary hyperemia is also impaired in PAD during isometric handgrip exercise. While CBV responses to handgrip were attenuated in PAD, the increase in BP and HR were similar to healthy subjects, which is consistent with other studies [16]. The pressor response generated during plantar flexion exercise is greater in PAD.…”

Section: Discussionsupporting

confidence: 91%

Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease

¹

,

²

,

³

et al. 2017

Annals of Vascular Surgery

View full text Add to dashboard Cite

STRUCTURED ABSTRACT Background Peripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD. Methods Twelve patients with PAD and no overt coronary disease (65 ± 2 yr, 7 men) and 15 healthy control subjects (64 ± 2 yr, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload). A subset of subjects (N = 7 PAD, N = 8 healthy) also performed isometric handgrip exercise (40% maximum voluntary contraction to fatigue). Coronary blood velocity in the left anterior descending artery was measured by transthoracic Doppler echocardiography; blood pressure and heart rate were monitored continuously. Results Coronary blood velocity responses to 4 minutes of plantar flexion exercise (PAD: Δ 2.4 ± 1.2, healthy: Δ 6.0 ± 1.6 cm/s, P = 0.039) and to isometric handgrip exercise (PAD: Δ 8.3 ± 4.2, healthy: Δ 16.9 ± 3.6, P = 0.033) were attenuated in PAD patients. Conclusions These data indicate that coronary exercise hyperemia is impaired in PAD, which may predispose these patients to myocardial ischemia.

“…Bakke EF et al, [19] also showed a increase in the mean arterial pressure, which was consistent with our study results. An increased total peripheral resistance was the main factor which caused an increase in the blood pressure.…”

Section: Discussionsupporting

confidence: 83%

The Isometric Handgrip Exercise As a Test for Unmasking Hypertension in the Offsprings of Hypertensive Parents

¹

,

et al. 2013

View full text Add to dashboard Cite

Background: A familial history of hypertension increases the risk of hypertension in the offsprings. Aims and objectives:The present study was undertaken to assess the underlying hypertension by using the Isometric Handgrip (IHG) exercise test in the offsprings of hypertensive parents and to compare it with age-matched controls of normotensive parents. Material and Methods:The isometric handgrip test was performed in the study and control groups. The resting blood pressure was recorded before exercise and afterwards the subjects were asked to perform the isometric handgrip exercise with the dominant hand for 2 minutes. Then the blood pressure was recorded in the sitting position during and 5 minutes after the completion of the exercise.Statistical Analysis: The analysis of the results was done by ANOVA with SPSS, version 17.0, by using the unpaired 't' test. Results:The results showed that the Resting Systolic (SBP), Diastolic (DBP) and the Mean (MBP) Blood Pressures were higher (p <0.001) in the offsprings of the hypertensive parents as compared to those in the control subjects of normotensive parents. During the isometric handgrip exercise test, the rise in the systolic, diastolic and the mean blood pressures was significantly higher (p<0.001) in the offsprings of the hypertensive parents. After 5 minutes of exercise, the SBP, DBP and the MBP were found to be significantly higher (p<0.001) in the study group as compared to those in the control group.Conclusions: An early and a regular screening of the children of hypertensive parents is necessary to prevent any future cardiovascular complications.

“…Cardiovascular responses during walking are altered in patients with PAD(3, 5). Previous studies have reported that blood pressure (BP) and heart rate (HR) both increase during constant load exercise in patients with PAD, but not in age matched controls(5).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Responses to Walking in Patients with Peripheral Artery Disease

¹

,

²

,

³

et al. 2011

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Purposes To assess the cardiovascular responses during constant load walking and to identify predictors of this response in peripheral artery disease (PAD) patients. Methods Seventy-nine patients with PAD performed a constant load treadmill test (2 mph, 0% grade). During the test, systolic blood pressure (BP), diastolic BP, and heart rate (HR) were obtained at the fourth minute to the last minute of exercise. Patients were also characterized on demographic measures, cardiovascular risk factors, baseline exercise performance and vascular measures. Results During constant load walking, there was a significant increase (p<0.01) in systolic BP (+12 ± 10 mmHg), diastolic BP (+6 ± 9 mmHg), and HR (+5 ± 5 bpm). The HR responses was negatively correlated with ischemic window (r= −0.23; p<0.05), expressed as an area under the curve of the resting ankle systolic BP and its recovery from maximal graded treadmill test, and positively correlated with the HR during the first minute of recovery from maximal graded treadmill test (r= 0.27; p<0.05). The increase in cardiovascular variables during constant load walking was greater in subjects with higher body mass index and in men (p<0.05). Conclusion Patients with PAD had an increased cardiovascular response during constant load walking, and these responses were greater in obese patients and in men. The clinical implication is that PAD patients engaged in walking training programs, particularly men and those with obesity, require frequent assessment of cardiovascular parameters to avoid exaggerated increases in BP and HR during constant load walking.

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Product

Browser Extension Assistant by scite Citation Statement Search Reference Check Visualizations Dashboards Explore Journals Explore Organizations Explore Funders Embedding Badge Embedding Citation Search Pricing

Resources

Blog Help & FAQ Accessibility Statement API Terms For Universities & Governments For Researchers For Publishers For Corporate, Pharma & Enterprise Author Marketing Become an Affiliate Get an organization trial or quote scite Data & Services

About

News & Press Careers Read our Paper Coverage

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Copyright © 2025 scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.