Blood pressure variability: Epidemiological and clinical issues

Krzych, Łukasz J.; Bochenek, Andrzej

doi:10.5603/cj.2013.0022

Cited by 13 publications

(8 citation statements)

References 86 publications

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“…According to the IDACO (an International Database on Ambulatory BP in relation to Cardiovascular Outcome) database, a 16-mm Hg increase in the nocturnal SBP was associated with stroke events (HR 1.08 [1.01-1.16]; p < 0.001) [10]. In 1,187 essential hypertension patients followed up for 3.2 years, Krzych et al [22] found that the occurrence of adverse CV events was nearly three times higher in non-dipper patients than dipper hypertensive patients [22].…”

Section: Discussionmentioning

confidence: 99%

Effect of bedtime administration of blood-pressure lowering agents on ambulatory blood pressure monitoring results: A meta-analysis

Sun¹,

Yu²,

Liu³

et al. 2016

Cardiol J.

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Section: Discussionmentioning

confidence: 99%

Effect of bedtime administration of blood-pressure lowering agents on ambulatory blood pressure monitoring results: A meta-analysis

Sun¹,

Yu²,

Liu³

et al. 2016

Cardiol J.

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“…Нині проблеми здоров'я людини та соціуму, пов'язані з підвищеним артеріальним тиском, займають лідируючу позицію як у країнах Європи, так і в Америці. Оприлюднено епідеміологічні та клінічні аспекти варіабельності артеріального тиску (Krzych and Bochek, 2013;Kozeba et al, 2015). Артеріальна гіпертензіяпричина смерті людей як похилого, так і молодого віку, незважаючи на досягнення сучасної аритмології (Stevenson, 2013).…”

Section: вступunclassified

Dyslipidemia in patients with arterial hypertension and extrasystoles

Didyc

2016

VDNUBM

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The significant incidence of hypertensive disease among the Ukrainian population makes the search for new methods of management and treatment of patients suffering from this pathology a matter of high priority. Our research is focused on study of changes of some biochemical parameters in patients suffering from hypertensive disease as well as patients suffering from hypertensive disease and coexistent extrasystoles. Arterial hypertension leads to different structural and functional changes in the cardiovascular system. In many patients these changes may result in rhythm disorders. 120 patients have been examined (42 men and 78 women) between the ages of 27 to 81 (average 59.8) suffering from hypertensive disease of the II stage as defined by the Ukrainian Association of Cardiologists and from extrasystoles (more than 30 episodes per hour of research) of different topography and 30 persons (13 men and 17 women) suffering from hypertensive disease of the II stage between the ages 30 to 76 (average 56.4) without rhythm disturbance). The first clinical group was formed by 54 (45%) patients suffering from repeated supraventricular extrasystoles (SE) (average 62 ± 2 SE per hour of research). The second clinical group was formed by 42 (35%) patients suffering from repeated ventricular arhythmia (VA) (average 37 ± 2 VA per hour of research). The third group was formed by 24 (20%) patients suffering from both repeated SE and VA (average 48 ± 3 SE and 32 ± 3 VA per hour of research). We conducted 24 hours’ monitoring of blood pressure and electrocardiography using the “Dia Card”-system (“Solvaig”, Ukraine) for all patients. This revealed that ventricle extrasystoles and combined extrasystoles in patients with essential hypertension, II stage are associated with more unfavourable changes in 24 hours’ profile of blood pressure. The paper analyses the cardiac arhythmia structure of heart rate variability in patients with arterial hypertension (AH) and extrasystoles. The findings confirmed the presence of desynchronization in the activity of the neurohnmoral system. Thus, different mechanisms of arhythmogenesis were revealed in patients with arterial hypertension. In the results, frequent ventricular and combined extrasystoles were associated with an unfavourable blood pressure profile during 24-hours monitoring as well as higher end-diastolic left ventricular volume, diastolic dysfunction, aortic valve fibrosis, aorta remodeling, endothelial dysfunction and more prominent lipid disorders. Supraventricular extrasystoles were associated with hypertriglyceridemia, left ventricular diastolic dysfunction and left atrium enlargement.

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“…[6] Non-dipper hypertensive patients manifest an increased mortality risk, cardiac and extracardiac morbidity. [7,8] Possible underlying mechanisms of non-dipper profile were explored in a multitude of studies conducted over the years, identifying clinical conditions linked to disturbances of 24-h systolic and/or diastolic BP variations. [9] Complex mechanisms originating in endocrine, renal, neural, and vascular areas are involved in the pathogenesis of arterial hypertension and its circadian variability.…”

Section: Introductionmentioning

confidence: 99%

Clinical Conditions and Predictive Markers of Non-Dipper Profile in Hypertensive Patients

Ţilea

Petra

Ardeleanu

et al. 2018

Acta Medica Marisiensis

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Hypertension remains one of the primary causes of premature cardiovascular mortality representing a major independent risk factor.The importance of ambulatory blood pressure monitoring in clinical evaluation of hypertensive patients, beyond diagnosis, is the identification of circadian dipping/non-dipping profile. The non-dipper pattern in hypertensive and normotensive patients is associated with significant target organ damage and worse outcomes, as an increased cardiovascular risk condition. Non-dipping pattern has been found to be associated with specific clinical conditions. Obesity, diabetes mellitus, metabolic syndrome, obstructive sleep apnea syndrome, chronic kidney disease, autonomic and baroreflex dysfunctions, salt sensitivity, hormonal changes, gender and age were extensively studied. Research efforts are focused on recognizing and exploring predictive markers of abnormal blood pressure circadian pattern. Previous studies acknowledge that red cell distribution width, mean platelet volume, fibrinogen level, C-reactive protein, serum uric acid and gamma-glutamyltransferase, are independently significant and positive associated to non-dipping pattern. Moreover, research on new biomarkers are conducted: Chitinase 3-Like-Protein 1, atrial and B-type natriuretic peptide, brain-derived neurotrophic factor, chemerin, sphingomyelin and the G972R polymorphism of the insulin receptor substrate-1 gene. This review summarizes the current knowledge of different clinical conditions and biomarkers associated with the non-dipper profile in hypertensive patients.

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Blood pressure variability: Epidemiological and clinical issues

Abstract: (Cardiol J 2013; 20, 2: 112-120)

Cited by 13 publications

References 86 publications

Effect of bedtime administration of blood-pressure lowering agents on ambulatory blood pressure monitoring results: A meta-analysis

Effect of bedtime administration of blood-pressure lowering agents on ambulatory blood pressure monitoring results: A meta-analysis

Dyslipidemia in patients with arterial hypertension and extrasystoles

Clinical Conditions and Predictive Markers of Non-Dipper Profile in Hypertensive Patients

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