Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Supruniuk, Elżbieta; Maciejczyk, Mateusz; Górski, Jan; Chabowski, Adrian

doi:10.3390/ijms21218071

Cited by 12 publications

(13 citation statements)

References 92 publications

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“…The results obtained are in good agreement with the data of a number of publications in which similar studies were performed on rats (Shogo et al, 2019;Ahn and Kim, 2020;Supruniuk et al, 2020). However, we did not find data on the Shift training influence in old age animals in these publications.…”

Section: Resultssupporting

confidence: 91%

Treadmill Training Effect on the Myokines Content in Skeletal Muscles of Mice With a Metabolic Disorder Model

et al. 2021

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The effect of treadmill training loads on the content of cytokines in mice skeletal muscles with metabolic disorders induced by a 16 week high fat diet (HFD) was studied. The study included accounting the age and biorhythmological aspects. In the experiment, mice were used at the age of 4 and 32 weeks, by the end of the experiment—respectively 20 and 48 weeks. HFD feeding lasted 16 weeks. Treadmill training were carried out for last 4 weeks six times a week, the duration 60 min and the speed from 15 to 18 m/min. Three modes of loading were applied. The first subgroup was subjected to stress in the morning hours (light phase); the second subgroup was subjected to stress in the evening hours (dark phase); the third subgroup was subjected to loads in the shift mode (the first- and third-weeks treadmill training was used in the morning hours, the second and fourth treadmill training was used in the evening hours). In 20-week-old animals, the exercise effect does not depend on the training regime, however, in 48-week-old animals, the decrease in body weight in mice with the shift training regime was more profound. HFD affected muscle myokine levels. The content of all myokines, except for LIF, decreased, while the concentration of CLCX1 decreased only in young animals in response to HFD. The treadmill training caused multidirectional changes in the concentration of myokines in muscle tissue. The IL-6 content changed most profoundly. These changes were observed in all groups of animals. The changes depended to the greatest extent on the training time scheme. The effect of physical activity on the content of IL-15 in the skeletal muscle tissue was observed mostly in 48-week-old mice. In 20-week-old animals, physical activity led to an increase in the concentration of LIF in muscle tissue when applied under the training during the dark phase or shift training scheme. In the HFD group, this effect was significantly more pronounced. The content of CXCL1 did not change with the use of treadmill training in almost all groups of animals. Physical activity, introduced considering circadian rhythms, is a promising way of influencing metabolic processes both at the cellular and systemic levels, which is important for the search for new ways of correcting metabolic disorders.

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Section: Resultssupporting

confidence: 91%

Treadmill Training Effect on the Myokines Content in Skeletal Muscles of Mice With a Metabolic Disorder Model

et al. 2021

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“…This effect may be explained, at least in part, by increasing the activity of antioxidant enzymes such as erythrocyte GR and, as a consequence, plasma levels of reduced glutathione. In contrast to single bouts of exercise [ 25 ], regular exercise induced an increased antioxidant enzyme activity that was able to reduce markers of oxidative damage to lipids and proteins in the current study.…”

Section: Discussioncontrasting

confidence: 50%

A Short‐Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome

Rosety-Rodriguez

Bernardi²,

Elosegui

et al. 2021

Oxidative Medicine and Cellular Longevity

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Previous studies have found aerobic training improved oxidative damage in people with Down syndrome (DS). However, there is a lack of information regarding the influence of resistance training on redox imbalance in this population. Accordingly, this study was conducted to determine the effect of resistance training (RT) on antioxidant defence system in sedentary adults with DS. Thirty-six male adults with DS were recruited through different community support groups. Eighteen were randomly assigned to perform a circuit RT program with 6 stations, 3 days/week for 12 weeks. Plasma total antioxidant status (TAS), reduced glutathione (GHS), ascorbate, serum α-tocopherol, and erythrocyte glutathione reductase activity were assessed. Plasma malondialdehyde (MDA) and carbonyl groups (CG) were assessed as markers of oxidative damage. Muscle strength was also measured. Dynamic torque of knee extensors and flexors as well as maximal handgrip strength was significantly improved after the completion of the training program. Plasma levels of TAS and erythrocyte glutathione reductase (GR) activity were significantly increased. Conversely, MDA and CG levels were significantly reduced. It was concluded RT improved antioxidant defence system and reduced oxidative damage in adults with DS. Further, long-term studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS.

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“…Therefore, for the assessment of OS/nitrosative stress, the products of free radical interactions with cell components are most often used. They are much more durable than free radicals and provide information on the consequences of oxidative/nitrosative damage to the body [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…OS is defined as an oxidative-reductive imbalance (in favor of oxidation reactions) depending on lipid raft turnover, mitochondrial function, and cellular cross-talk in the neurovascular coupling [ 5 , 6 ]. Excessive formation of reactive oxygen species (ROS) generates oxidative damage to various macromolecules (i.e., proteins, lipids, and DNA), changing several signaling pathways and promote cellular injury and death [ 5 , 7 ]. In ischemic stroke, excess calcium, sodium, and ADP levels are responsible for the overproduction of mitochondrial free radicals.…”

Section: Introductionmentioning

confidence: 99%

Salivary Gland Dysfunction in Stroke Patients Is Associated with Increased Protein Glycoxidation and Nitrosative Stress

Maciejczyk

Gerreth²,

Hojan

et al. 2020

Oxidative Medicine and Cellular Longevity

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Stroke is one of the leading causes of disability and death worldwide. Despite intensive medical care, many of the complaints directly threatening the patient’s life marginalize their dental needs after the stroke. Recent studies indicate reduced saliva secretion in stroke patients in addition to the increased incidence of caries and periodontal disease. Since oxidative stress plays a vital role in the pathogenesis of salivary gland hypofunction and neurodegenerative disorders (including stroke), this is the first to evaluate the relationship between salivary gland activity and protein glycoxidation and nitrosative damage. The content of glycation and protein oxidation products and nitrosative stress was assessed in nonstimulated (NWS) and stimulated (SWS) whole saliva of stroke patients with normal salivary secretion and hyposalivation (reduced saliva production). The study included 30 patients in the stroke’s subacute phase and 30 healthy controls matched by age and sex. We have shown that stroke patients with hyposalivation show increased contents of protein glycation (↑Amadori products and ↑advanced glycation end products), glycoxidation (↑dityrosine), and nitration (↑nitrotyrosine) products compared to stroke cases with normal salivary secretion and control group. Interestingly, higher oxidative/nitrosative stress was found in NWS, which strongly correlates with salivary flow rate, total protein content, and salivary amylase activity. Such relationships were not observed in the control group. Summarizing, oxidative and nitrosative stress may be one of the mechanisms responsible for the impairment of saliva secretion in stroke patients. However, extraglandular sources of salivary oxidative stress in stroke patients cannot be excluded. Further studies to assess salivary gland hypofunction in stroke cases are necessary.

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Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Cited by 12 publications

References 92 publications

Treadmill Training Effect on the Myokines Content in Skeletal Muscles of Mice With a Metabolic Disorder Model

Treadmill Training Effect on the Myokines Content in Skeletal Muscles of Mice With a Metabolic Disorder Model

A Short‐Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome

Salivary Gland Dysfunction in Stroke Patients Is Associated with Increased Protein Glycoxidation and Nitrosative Stress

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