Blood Protein Variations in Baboons

Male dispersal from the natal group at or near maturity is a feature of most baboon (Papio) species. It potentially has profound effects upon population structure and evolutionary processes, but dispersal, especially for unusually long distances, is not readily documented by direct field observation. In this pilot study, we investigate the possibility of retrieving baboon population structure in yellow (Papio cynocephalus) and kinda (Papio kindae) baboons from the distribution of variation in a genome-wide set of 494 Alu insertion polymorphisms, made available via the recently completed Baboon Genome Analysis Consortium. Alu insertion variation in a mixed population derived from yellow and olive (Papio anubis) baboons identified each individual’s proportion of heritage from either parental species. In an unmixed yellow baboon population, our analysis showed greater similarity between neighboring than between more distantly situated groups, suggesting structuring of the population by male dispersal distance. Finally (and very provisionally), an unexpectedly sharp difference in Alu insertion frequencies between members of neighboring social groups of kinda baboons suggests that intergroup migration may be more rare than predicted in this little known species.

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“…These include isozymes ( Olivier etal. 1974 ; Shotake etal. 1977 ; Rogers and Kidd 1993 ), RFLPs ( Newman etal.…”

Section: Introductionmentioning

confidence: 99%

Alu Insertion Polymorphisms as Evidence for Population Structure in Baboons

Steely

Walker

Jordan

et al. 2017

Genome Biology and Evolution

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Blood‐protein allele frequencies and phylogenetic relationships in Macaca: A review

Fooden

Lanyon

1989

American J Primatol

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Allele-frequency data have been assembled for 35 blood-protein loci in 17 of 19 recognized species of Macaca based on 29 published electrophoretic studies; studies of inbred captive colonies have been excluded. Data for 22 polymorphic loci are tabulated in detail for 43 geographic populations of these species. Calculated FsT values provide a measure of intergroup genetic differentiation at various hierarchical levels-troop, locality, province, country or island, species, species group; polymorphism indices measure genetic variation. The greatest intraspecific genetic differentiation occurs at the level of island populations within species. The pattern of genetic variation among island populations appears to be relictual, suggesting that the reduced genetic variability of island populations of macaques is a result of postisolation genetic drift rather than founder effect. Interspecific relationships were investigated by means of a jackknifed Fitch-Margoliash algorithm, using Papio as outgroup. Phylogenetic inferences based on blood-protein evidence are largely compatible with inferences based on morphology and zoogeography. The reduced genetic variability that frequently characterizes insular macaque populations complicates phylogenetic interpretation of blood-protein evidence.

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Genetic differentiation between baboon subspecies: Relevance for biomedical research

Williams‐Blangero

VandeBerg

Blangero

et al. 1990

American J Primatol

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The use of common names which may encompass a number of subspecies or species is pervasive in the biomedical literature. Failure to identify the complete taxonomic classification of research subjects presents a source of error for scientists attempting to evaluate results or to repeat experiments. This paper examines the problem in a common animal model, the baboon. Analyses of the genetic distances among five baboon subspecies (Papio hamadryas anubis, P.h. cynocephalus, P.h. papio, P.h. ursinus, and P.h. hamadryas) based on blood marker information from nine polymorphic protein loci (ADA, APRT, C3, C A l , CA2, GPI, MPI, PEPB, and PGD) available for baboons resident at the Southwest Foundation for Biomedical Research are presented. Statistical tests on the distances showed that significant genetic differences exist among the subspecies. A comparison of P.h. anubis and P.h. cynocephalus revealed that these two subspecies also differ significantly for biomedically relevant lipoprotein cholesterol levels, as can be predicted from the genetic distances. The results emphasize the pitfalls of using different types of baboons interchangeably in experimental protocols.

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Blood Protein Variations in Baboons

Cited by 38 publications

References 22 publications

Alu Insertion Polymorphisms as Evidence for Population Structure in Baboons

Alu Insertion Polymorphisms as Evidence for Population Structure in Baboons

Blood‐protein allele frequencies and phylogenetic relationships in Macaca: A review

Genetic differentiation between baboon subspecies: Relevance for biomedical research

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