Blood-specific whole-body electromagnetic hyperthermia

Babincová, Melánia; Sourivong, P.; Leszczyńska, Danuta; Babinec, Peter

doi:10.1054/mehy.2000.1089

Cited by 42 publications

(27 citation statements)

References 11 publications

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“…Magnetic nanoparticles are physiologically inert, with no measurable LD50 [2,3], but when they enter the bloodstream, they are rapidly coated with plasma proteins in a process known as opsonization [4]. The opsonized particles may be recognized by the reticuloendothelial system (RES) and macrophages may remove them by phagocytosis.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional magnetic nanoparticles for targeted delivery

Kumar

Jena

Behera

et al. 2010

Nanomedicine: Nanotechnology, Biology and Medicine

155

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A major problem associated with therapy is the inability to deliver pharmaceuticals to a specific site of the body without causing nonspecific toxicity. Development of magnetic nanoparticles and techniques for their safe transport and concentration in specific sites in the body would constitute a powerful tool for gene/drug therapy in vivo. Furthermore, drug delivery in vitro could improve further if the drugs were modified with antibodies, proteins or ligands. For in vivo experiments, magnetic nanoparticles were conjugated with plasmid DNA expressing GFP and then coated with chitosan. These particles were injected into mice through tail vein and directed to heart and kidney by means of external magnets of 25 gauss or 2kA –kA/m. These particles were concentrated in the lungs, heart, and kidney of mice and the expression of GFP in these sites were monitored. The expression of GFP in specific locations was visualized by whole-body fluorescent imaging and the concentration of these particles in the designated body locations was confirmed by transmission electron microscopy. In another model system, we used atrial natriuretic peptide (ANP) and Carcino Embryonic Antigen (CEA) antibodies coupled to the chitosan coated magnetic nanoparticles to target cells in vitro. The present work demonstrates that a simple external magnetic field is all that is necessary to target a drug to a specific site inside the body without the need to functionalize the nanoparticles. However, the option to use magnetic targeting with external magnets on functionalized nanoparticles could prove as a more efficient means of drug delivery.

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Section: Introductionmentioning

confidence: 99%

Multifunctional magnetic nanoparticles for targeted delivery

Kumar

Jena

Behera

et al. 2010

Nanomedicine: Nanotechnology, Biology and Medicine

155

View full text Add to dashboard Cite

show abstract

“…In addition, the interactions between DPPC and other molecules, such as drug and surfactant, may cause the phase transition temperature T m change [20][21][22] due to the microstructural transformation of DPPC bilayer membrane. As identified by DSC technique, the main T m of DPPC bilayer membrane is 40.09 • C, and that of Mn 2+ , Mg 2+ , Cu 2+ and Zn 2+ introduced membranes were increased to 43.73, 42.83, 42.47 and 42.58 • C, respectively (Fig.…”

Section: Dsc Analysismentioning

confidence: 99%

Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency

Liu

Zhang

Han

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Babincova et al also reported dextran-magnetite has no measurable toxicity index LD50. 32,33 Fig .17 shows that the heating curves of Fe 3 O 4 particles with and without SiO 2 shell in the ac magnetic field with 43.1 mT and 72kHz. The average particle size is 30 nm and the shell thickness is about 10 nm.…”

Section: Magnetic Fluid Hyperthermia Behaviormentioning

confidence: 99%