Blood Sugar Lowering Activity of<i>Swertia chirata</i>(Buch-Ham) Extract

Mukherjee, B.; Mukherjee, S. K.

doi:10.3109/13880208709088134

Cited by 20 publications

(6 citation statements)

References 2 publications

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“…The oral route of administration was preferred as it is simple and physiological. Albino rats were chosen for experiments because the blood sugar level of rats remains fairly stable during handling, unlike other animals, such as rabbits (Mukherjee and Mukherjee, 1987). Five different test models were used to increase the sensitivity of the evaluation procedure.…”

Section: Discussionmentioning

confidence: 99%

Oral Hypoglycemic Effect of Caesalpinia bonducella

Biswas

Bandyopadhyay

Mukherjee

et al. 1997

International Journal of Pharmacognosy

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The blood sugar lowering efficacy of the aqueous extract of Caesalpinia bonducella F. (seed shell) was evaluated in fasted, fed, glucose loaded, streptozotocin diabetic, and alloxan diabetic rat models. The extract was administered orally at a dose of 250 mg/kg of rat body weight. It produced very significant blood sugar lowering (at least P < 0.005) in glucose loaded, streptozotocin diabetic, and alloxan diabetic models. However, effects were not so pronounced in fasted and fed models. As a whole, Caesalpinia bonducella can be regarded as a good oral hypoglycemic agent in rat.

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Section: Discussionmentioning

confidence: 99%

Oral Hypoglycemic Effect of Caesalpinia bonducella

Biswas

Bandyopadhyay

Mukherjee

et al. 1997

International Journal of Pharmacognosy

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“…Because of its bitter taste, infusions of the plant have been used extensively as stomachic, anthelmintic, bitter tonic and had replaced the official Gentiana preparations as a febrifuge from time to time. While studying the blood sugar lowering effect, if any, of plants having bitter taste, it was observed that the 95 % ethanolic extract of the whole plant of Swertia chirayif a could lower blood sugar in some experimental rat models (1). The alcoholic crude extract was further fractionated and it was found that the hexane fraction lowered blood sugar in several rat models, the maximum blood sugar lowering being 27%.…”

Section: Methodsmentioning

confidence: 99%

Hypoglycemic Effect of Swerchirin from the Hexane Fraction ofSwertia chirayita

Bajpai¹,

Asthana²,

Sharma³

et al. 1991

Planta Med

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A xanthone was isolated from the hexane fraction of the Swertia chirayita plant and identified as 1,8-dihydroxy-3,5-dimethoxyxanthone (swerchirin). It has a very significant blood sugar lowering effect in fasted, fed, glucose loaded, and tolbutamide pretreated albino rat models. The ED50 for 40% blood sugar lowering in CF male albino rats (body weight 140-165 g) is 23.1 mg/kg/oral. The possibility of its application in clinical therapy for diabetes mellitus needs exploration.

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“…Recently, the hexane extract of the plant has been shown to possess promising hypoglycaemic activity (Chakravarty et al, 1994). S. chirata found a place among useful medicinal plants of east and southeast Asia as a bitter tonic, febrifuge, stomachic, laxative and blood puri®er (Mukherjee and Mukherjee, 1987).…”

Section: Use Of Plant Sources Containing Tetraoxygenated Xanthonesmentioning

confidence: 99%

Tetraoxygenated naturally occurring xanthones

2000

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This review, with 350 references, gives information on the chemical study of 234 naturally occurring tetraoxygenated xanthones in 12 families, 53 genus and 182 species of higher plants, and two which are described as fungal and lichen metabolites. The value of these groups of substances in connection with pharmacological activity and therapeutic use of some species is described. The structural formulas of 135 isolated compounds, and their distribution, are also given.

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Blood Sugar Lowering Activity ofSwertia chirata(Buch-Ham) Extract

Cited by 20 publications

References 2 publications

Oral Hypoglycemic Effect of Caesalpinia bonducella

Oral Hypoglycemic Effect of Caesalpinia bonducella

Hypoglycemic Effect of Swerchirin from the Hexane Fraction ofSwertia chirayita

Tetraoxygenated naturally occurring xanthones

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